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Antibiotics, Volume 11, Issue 2

February 2022 - 163 articles

Cover Story: The incidence of urinary tract infections (UTIs) caused by extended-spectrum B-lactamase-producing Enterobacterales (ESBL-E) has increased in French hospitals, and E. coli strains are the most prevalent species among ESBL-E. This resistance is often accompanied by co-resistance to fluoroquinolones and TMP/SMX. The therapeutic choice is limited and often concerns carbapenems, which remain the gold standard for most ESBL-E infections. Oral fosfomycin-trometamol (FT) could be an alternative to carbapenems in male ESBL-E UTIs, with a high microbiological eradication rate and a simple administration, but needs to be balanced against the risk of drug interactions and adverse effects. In this current paper, we were interested in describing the clinical evolution and safety of male MDR Enterobacterales UTI cases treated with oral FT. View this paper
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Articles (163)

  • Brief Report
  • Open Access
19 Citations
4,603 Views
8 Pages

Early and Late Onset Neonatal Sepsis: Epidemiology and Effectiveness of Empirical Antibacterial Therapy in a III Level Neonatal Intensive Care Unit

  • Marcello Mariani,
  • Alessandro Parodi,
  • Diego Minghetti,
  • Luca A. Ramenghi,
  • Candida Palmero,
  • Elisabetta Ugolotti,
  • Chiara Medici,
  • Carolina Saffioti and
  • Elio Castagnola

21 February 2022

Bloodstream infections play an important role in neonatal morbidity and mortality. In this study, we retrospectively analyzed etiology and antibiotic resistance profiles of bacteria isolated from blood or Cerebro Spinal Fluid (CSF) cultures to evalua...

  • Article
  • Open Access
3,305 Views
13 Pages

PK-PD Modeling and Optimal Dosing Regimen of Acetylkitasamycin against Streptococcus suis in Piglets

  • Anxiong Huang,
  • Feng Mao,
  • Lingli Huang,
  • Shuyu Xie,
  • Yuanhu Pan,
  • Wei Qu,
  • Guyue Cheng,
  • Zhenli Liu,
  • Zonghui Yuan and
  • Dapeng Peng
  • + 1 author

21 February 2022

Streptococcus suis (S. suis) causes severe respiratory diseases in pigs and is also an important pathogen causing hidden dangers to public health and safety. Acetylkitasamycin is a new macrolide agent that has shown good activity to Gram-positive coc...

  • Article
  • Open Access
4 Citations
2,492 Views
13 Pages

A Double Payload Complex between Hypericin and All-trans Retinoic Acid in the β-Lactoglobulin Protein

  • Beatriz Rodríguez-Amigo,
  • Cormac Hally,
  • Núria Roig-Yanovsky,
  • Pietro Delcanale,
  • Stefania Abbruzzetti,
  • Montserrat Agut,
  • Cristiano Viappiani and
  • Santi Nonell

21 February 2022

Combined therapies are usually used to treat acne vulgaris since this approach can tackle various foci simultaneously. Using a combination of spectroscopic, computational, and microbiological techniques and methods, herein we report on the use of β-l...

  • Article
  • Open Access
15 Citations
4,966 Views
29 Pages

Quantitative Risk Assessment for the Introduction of Carbapenem-Resistant Enterobacteriaceae (CPE) into Dutch Livestock Farms

  • Natcha Dankittipong,
  • Egil A. J. Fischer,
  • Manon Swanenburg,
  • Jaap A. Wagenaar,
  • Arjan J. Stegeman and
  • Clazien J. de Vos

21 February 2022

Early detection of emerging carbapenem-resistant Enterobacteriaceae (CPE) in food-producing animals is essential to control the spread of CPE. We assessed the risk of CPE introduction from imported livestock, livestock feed, companion animals, hospit...

  • Article
  • Open Access
11 Citations
3,133 Views
12 Pages

Statins Induce Actin Cytoskeleton Disassembly and an Apoptosis-Like Process in Acanthamoeba spp.

  • Rubén L. Rodríguez-Expósito,
  • Ines Sifaoui,
  • María Reyes-Batlle,
  • Sutherland K. Maciver,
  • José E. Piñero and
  • Jacob Lorenzo-Morales

21 February 2022

Acanthamoeba is a ubiquitous opportunistic protozoan pathogen that is known to cause blinding keratitis and rare, but usually fatal, granulomatous encephalitis. The difficulty in treating infections and the toxicity issues of the current treatments e...

  • Article
  • Open Access
10 Citations
6,233 Views
23 Pages

Surgical Antimicrobial Prophylaxis in Abdominal Surgery for Neonates and Paediatrics: A RAND/UCLA Appropriateness Method Consensus Study

  • Sonia Bianchini,
  • Erika Rigotti,
  • Sara Monaco,
  • Laura Nicoletti,
  • Cinzia Auriti,
  • Elio Castagnola,
  • Giorgio Conti,
  • Luisa Galli,
  • Mario Giuffrè and
  • Stefania La Grutta
  • + 13 authors

21 February 2022

Surgical site infections (SSIs), i.e., surgery-related infections that occur within 30 days after surgery without an implant and within one year if an implant is placed, complicate surgical procedures in up to 10% of cases, but an underestimation of...

  • Review
  • Open Access
61 Citations
10,144 Views
18 Pages

20 February 2022

Following the European Union’s restriction on antibiotic growth promoters, research on enhancing gut health has been accelerated. As the poultry industry is facing issues that were previously managed by antimicrobial growth promoters, the hunt...

  • Review
  • Open Access
33 Citations
7,550 Views
33 Pages

20 February 2022

With the current crisis related to the emergence of carbapenem-resistant Gram-negative bacteria (CR-GNB), classical treatment approaches with so-called “old-fashion antibiotics” are generally unsatisfactory. Newly approved β-lactam/&...

  • Systematic Review
  • Open Access
9 Citations
4,928 Views
14 Pages

Safety and Efficacy of Devices Delivering Inhaled Antibiotics among Adults with Non-Cystic Fibrosis Bronchiectasis: A Systematic Review and a Network Meta-Analysis

  • Sofia Tejada,
  • Sergio Ramírez-Estrada,
  • Carlos G. Forero,
  • Miguel Gallego,
  • Joan B. Soriano,
  • Pablo A. Cardinal-Fernández,
  • Stephan Ehrmann and
  • Jordi Rello

19 February 2022

It remains unknown whether the type of aerosol generating device is affecting efficacy and safety among non-cystic fibrosis bronchiectasis (NCFB) adults. The proposal of this network meta-analysis (NMA) is to evaluate effectiveness and safety of inha...

  • Article
  • Open Access
34 Citations
7,184 Views
12 Pages

Evaluation of Bi-Lateral Co-Infections and Antibiotic Resistance Rates among COVID-19 Patients

  • Naveed Ahmed,
  • Madiha Khan,
  • Waqas Saleem,
  • Mohmed Isaqali Karobari,
  • Roshan Noor Mohamed,
  • Artak Heboyan,
  • Ali A. Rabaan,
  • Abbas Al Mutair,
  • Saad Alhumaid and
  • Salman A. Alsadiq
  • + 3 authors

19 February 2022

In addition to the pathogenesis of SARS-CoV-2, bacterial co-infection plays an essential role in the incidence and progression of SARS-CoV-2 infections by increasing the severity of infection, as well as increasing disease symptoms, death rate and an...

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Antibiotics - ISSN 2079-6382