Antimicrobial and Anti-infective Activity of Natural Products

Dear Colleagues,

Antimicrobial drugs represent one of the great scientific advances in the medical field. However, a dramatic increase in antimicrobial resistance has compromised the effectiveness of these drugs. Thus, there is an increased need to search for new antimicrobial compounds. A growing area of research in this regard is the investigation of antimicrobial activities in natural products from different sources, including plants, microorganisms, and animals. Another important area of research in combating resistant microorganisms is the investigation of compounds that neutralize or inactivate bacterial resistance mechanisms—for example, compounds that inhibit efflux pumps or beta-lactamases. Furthermore, there are molecules that can interfere with bacterial virulence properties. The main advantage claimed for antivirulence therapy is the reduced selective pressure on the pathogen and, consequently, the lower possibility of the emergence of resistance. This Special Issue aims to highlight the recent advances in the discovery of new antimicrobial compounds from natural products, mechanisms of action of pure compounds, in silico evidence of antimicrobial activity, synergistic associations with antibiotics, and compounds with antivirulence activity or capable of neutralizing bacterial resistance. We also welcome the submission of research papers that study alternative methods of demonstrating the in vivo efficacy of compounds or natural extracts.

Dr. Valério Monteiro-Neto
Dr. Elizabeth S. Fernandes
Guest Editors

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