Table of Contents
Biosensors, Volume 10, Issue 2 (February 2020) – 7 articles
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Cover Story (view full-size image) Ovarian cancer is associated with tumors that form in the tissue of the ovary. It is often referred [...] Read more. Ovarian cancer is associated with tumors that form in the tissue of the ovary. It is often referred to as the silent killer since early symptoms are not radically different from certain normal conditions. The disease kills many thousands of women annually. However, if detected in Stage 1, the five-year survival rate is over 90%, a fact that indicates the necessity for the development of a low-cost, screening-type assay. The present paper describes the detection of a known biomarker, lysophosphatidic acid (LPA), for the disease in serum at an early stage. The solid-phase method is based upon fluorescence measurement of labelled actin displaced by LPA from a gelsolin probe attached to silica nanoparticles. The protein, gelsolin, is a highly selective binding probe for LPA. The limit-of-detection of the assay is 5 µM in serum, which is a value close to that for detection of the Stage 1 presence of the biomarker.View this paper.