Table of Contents
Nanomaterials, Volume 8, Issue 6 (June 2018)
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Cover Story (view full-size image) Platinum nanoparticles (PtNPs) are internalized by THP-1 monocytes without affecting cell [...] Read more. Platinum nanoparticles (PtNPs) are internalized by THP-1 monocytes without affecting cell viability. The expression of CD14, CD11b, CCR2, and CCR5 is also not affected, nor is the basal release of inflammatory cytokines. However, PtNPs within THP-1 cells did not behave as a quiescent nanomaterial demonstrating catalytic activity by reducing reactive oxygen species (ROS) and modulating the transcription of 60 genes. We demonstrated that PtNPs are non-toxic, perform intracellular ROS scavenging, and possess good immune-compatibility, suggesting that they could be feasible synthetic nanozymes for applications in nanomedicine. View Paper here.