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Journal of Functional Biomaterials, Volume 14, Issue 12

2023 December - 14 articles

Cover Story: The use of 3D-printed titanium (Ti) cages offers a promising solution for osteoporosis-induced fractures and spinal fusion surgery. These implants, with superior strength compared to other metals, face challenges when used independently, particularly in soft tissue interactions. To address this, a 3D-printed Ti cage was infused with gelatin and hyaluronic acid (G-H) in this study. The G-H-filled mesh structure created micro-sized pores, acting as a bridge for cell migration. The slow release enhanced biocompatibility, up-regulating bone-related gene expressions. In a rabbit femur model, the G-H-coated Ti cage demonstrated superior bone regeneration, filling large holes as a cell migration bridge and expediting bone regrowth. View this paper
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Articles (14)

  • Article
  • Open Access
3 Citations
3,021 Views
13 Pages

Effect of Bioactive Glasses and Basic Fibroblast Growth Factor on Dental Pulp Cells

  • Ayako Washio,
  • Olivia Kérourédan,
  • Yasuhiko Tabata,
  • Shoichiro Kokabu and
  • Chiaki Kitamura

18 December 2023

Ideal regeneration of hard tissue and dental pulp has been reported with the use of a combination of bioactive glass and basic fibroblast growth factor (bFGF). However, no previous study has investigated the molecular mechanisms underlying the proces...

  • Article
  • Open Access
4 Citations
3,971 Views
12 Pages

Fracture Resistance of a Two-Piece Zirconia Implant System after Artificial Loading and/or Hydrothermal Aging—An In Vitro Investigation

  • Ralf-Joachim Kohal,
  • Tim Schikofski,
  • Erik Adolfsson,
  • Kirstin Vach,
  • Sebastian Berthold Maximilian Patzelt,
  • Julian Nold and
  • Gregor Wemken

15 December 2023

The purpose of the present study was to assess the fracture resistance of a two-piece alumina-toughened zirconia implant system with a carbon-reinforced PEEK abutment screw. Methods: Thirty-two implants with screw-retained zirconia abutments were div...

  • Article
  • Open Access
2,608 Views
15 Pages

Photochemical Modification of the Extracellular Matrix to Alter the Vascular Remodeling Process

  • Blake Anderson,
  • Dylan Blair,
  • Kenji Huff,
  • John Wisniewski,
  • Kevin S. Warner and
  • Katalin Kauser

15 December 2023

Therapeutic interventions for vascular diseases aim at achieving long-term patency by controlling vascular remodeling. The extracellular matrix (ECM) of the vessel wall plays a crucial role in regulating this process. This study introduces a novel ph...

  • Article
  • Open Access
3 Citations
3,465 Views
34 Pages

New Perspective for Using Antimicrobial and Cell-Penetrating Peptides to Increase Efficacy of Antineoplastic 5-FU in Cancer Cells

  • Nuno Vale,
  • Eduarda Ribeiro,
  • Inês Cruz,
  • Valentina Stulberg,
  • Beate Koksch and
  • Bárbara Costa

12 December 2023

This study explores the effectiveness of the antineoplastic agent 5-FU in cancer cells by leveraging the unique properties of cationic antimicrobial peptides (CAMPs) and cell-penetrating peptides (CPPs). Traditional anticancer therapies face substant...

  • Article
  • Open Access
3 Citations
4,597 Views
14 Pages

Oral Galvanism Side Effects: Comparing Alloy Ions and Galvanic Current Effects on the Mucosa-like Model

  • Natalia Chepelova,
  • Artem Antoshin,
  • Sergei Voloshin,
  • Anna Usanova,
  • Yuri Efremov,
  • Maria Makeeva,
  • Stanislav Evlashin,
  • Mikhail Stepanov,
  • Anna Turkina and
  • Peter Timashev

11 December 2023

The interaction of different dental alloys with the oral environment may cause severe side effects (e.g., burning sensation, inflammatory reactions, carcinogenesis) as a result of oral galvanism. However, the pathogenesis of side effects associated w...

  • Article
  • Open Access
4 Citations
3,277 Views
22 Pages

Model-Based Design to Enhance Neotissue Formation in Additively Manufactured Calcium-Phosphate-Based Scaffolds

  • Bingbing Liang,
  • Ehsan Sadeghian Dehkord,
  • Dorien Van Hede,
  • Mojtaba Barzegari,
  • Bruno Verlée,
  • Justine Pirson,
  • Grégory Nolens,
  • France Lambert and
  • Liesbet Geris

3 December 2023

In biomaterial-based bone tissue engineering, optimizing scaffold structure and composition remains an active field of research. Additive manufacturing has enabled the production of custom designs in a variety of materials. This study aims to improve...

  • Article
  • Open Access
4 Citations
2,949 Views
13 Pages

Evaluation of Gelatin/Hyaluronic Acid-Generated Bridging in a 3D-Printed Titanium Cage for Bone Regeneration

  • Seong-Su Park,
  • Ume Farwa,
  • Mosharraf Hossain,
  • Soobin Im and
  • Byong-Taek Lee

30 November 2023

3D-printed titanium (Ti) cages present an attractive alternative for addressing issues related to osteoporosis-induced fractures, accidental fractures, and spinal fusion surgery due to disc herniation. These Ti-based bone implants possess superior st...

  • Article
  • Open Access
6 Citations
3,493 Views
11 Pages

Titanium Biohybrid Middle Ear Prostheses: A Preliminary In Vitro Study

  • Mario Mosconi,
  • Elena Carlotto,
  • Laura Caliogna,
  • Micaela Berni,
  • Giulia Gastaldi,
  • Michele Conti,
  • Alice Maria Brancato,
  • Valentina Bina,
  • Domenico Minervini and
  • Pietro Canzi
  • + 5 authors

29 November 2023

Ossiculoplasty is a surgical operation performed to restore auditory transmission through the reconstruction of the ossicular chain using prosthetics. Tissue bioengineering has assumed a pivotal role in implementing alternatives to conventional ossic...

  • Article
  • Open Access
11 Citations
3,048 Views
20 Pages

The Effect of Silver and Samarium on the Properties of Bioglass Coatings Produced by Pulsed Laser Deposition and Spin Coating

  • Roxana Lavric,
  • Cornelia Vreme,
  • Cristina Busuioc,
  • Gabriela-Olimpia Isopencu,
  • Adrian-Ionut Nicoara,
  • Ovidiu-Cristian Oprea,
  • Daniel-Dumitru Banciu,
  • Izabela Constantinoiu and
  • Ana-Maria-Raluca Musat

28 November 2023

The current study reports the use of silver (Ag) and samarium (Sm) as dopants to improve the properties of standard bioglass in terms of biological performance. This experiment considers thin films of doped bioglass obtained by pulsed laser depositio...

  • Article
  • Open Access
3 Citations
2,374 Views
17 Pages

25 November 2023

The unique physical properties of heavy ion beams, particularly their distinctive depth–dose distribution and sharp lateral dose reduction profiles, have led to their widespread adoption in tumor therapy worldwide. However, the physical propert...

  • Article
  • Open Access
7 Citations
3,625 Views
20 Pages

Enhanced Stability of Dopamine Delivery via Hydrogel with Integrated Graphene

  • Cristina Mormile,
  • Ocsana Opriș,
  • Stefano Bellucci,
  • Ildiko Lung,
  • Irina Kacso,
  • Alexandru Turza,
  • Matteo La Pietra,
  • Cristian Vacacela Gomez,
  • Adina Stegarescu and
  • Maria-Loredana Soran

23 November 2023

The synthesis of graphene-based materials for drug delivery represents an area of active research, and the use of graphene in drug delivery systems is promising due to its unique properties. Thus, in the present work, we discuss the potential of few-...

  • Article
  • Open Access
10 Citations
3,464 Views
20 Pages

23 November 2023

The porous structure can reduce the elastic modulus of a dental implant and better approximate the elastic characteristics of the material to the alveolar bone. Therefore, it has the potential to alleviate bone stress shielding around the implant. Ho...

  • Article
  • Open Access
13 Citations
3,523 Views
20 Pages

The Effect of Chitosan/Alginate/Graphene Oxide Nanocomposites on Proliferation of Mouse Spermatogonial Stem Cells

  • Alaa Moeinzadeh,
  • Behnaz Ashtari,
  • Heriberto Garcia,
  • Morteza Koruji,
  • Carlo Alberto Velazquez,
  • Zohreh Bagher,
  • Mahmood Barati,
  • Ronak Shabani and
  • Seyed Mohammad Davachi

22 November 2023

Male survivors of childhood cancer have been known to be afflicted with azoospermia. To combat this, the isolation and purification of spermatogonial stem cells (SSCs) are crucial. Implementing scaffolds that emulate the extracellular matrix environm...

  • Article
  • Open Access
6 Citations
3,264 Views
13 Pages

A Synergic Strategy: Adipose-Derived Stem Cell Spheroids Seeded on 3D-Printed PLA/CHA Scaffolds Implanted in a Bone Critical-Size Defect Model

  • Gabriela S. Kronemberger,
  • Thiago Nunes Palhares,
  • Alexandre Malta Rossi,
  • Brunno R. F. Verçosa,
  • Suelen C. Sartoretto,
  • Rodrigo Resende,
  • Marcelo J. Uzeda,
  • Adriana T. N. N. Alves,
  • Gutemberg G. Alves and
  • Leandra Santos Baptista
  • + 2 authors

21 November 2023

Bone critical-size defects and non-union fractures have no intrinsic capacity for self-healing. In this context, the emergence of bone engineering has allowed the development of functional alternatives. The aim of this study was to evaluate the capac...

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J. Funct. Biomater. - ISSN 2079-4983