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Journal of Functional Biomaterials, Volume 14, Issue 12

December 2023 - 14 articles

Cover Story: The use of 3D-printed titanium (Ti) cages offers a promising solution for osteoporosis-induced fractures and spinal fusion surgery. These implants, with superior strength compared to other metals, face challenges when used independently, particularly in soft tissue interactions. To address this, a 3D-printed Ti cage was infused with gelatin and hyaluronic acid (G-H) in this study. The G-H-filled mesh structure created micro-sized pores, acting as a bridge for cell migration. The slow release enhanced biocompatibility, up-regulating bone-related gene expressions. In a rabbit femur model, the G-H-coated Ti cage demonstrated superior bone regeneration, filling large holes as a cell migration bridge and expediting bone regrowth. View this paper
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Articles (14)

  • Article
  • Open Access
3 Citations
2,693 Views
13 Pages

Effect of Bioactive Glasses and Basic Fibroblast Growth Factor on Dental Pulp Cells

  • Ayako Washio,
  • Olivia Kérourédan,
  • Yasuhiko Tabata,
  • Shoichiro Kokabu and
  • Chiaki Kitamura

18 December 2023

Ideal regeneration of hard tissue and dental pulp has been reported with the use of a combination of bioactive glass and basic fibroblast growth factor (bFGF). However, no previous study has investigated the molecular mechanisms underlying the proces...

  • Article
  • Open Access
3 Citations
3,565 Views
12 Pages

Fracture Resistance of a Two-Piece Zirconia Implant System after Artificial Loading and/or Hydrothermal Aging—An In Vitro Investigation

  • Ralf-Joachim Kohal,
  • Tim Schikofski,
  • Erik Adolfsson,
  • Kirstin Vach,
  • Sebastian Berthold Maximilian Patzelt,
  • Julian Nold and
  • Gregor Wemken

15 December 2023

The purpose of the present study was to assess the fracture resistance of a two-piece alumina-toughened zirconia implant system with a carbon-reinforced PEEK abutment screw. Methods: Thirty-two implants with screw-retained zirconia abutments were div...

  • Article
  • Open Access
2,406 Views
15 Pages

Photochemical Modification of the Extracellular Matrix to Alter the Vascular Remodeling Process

  • Blake Anderson,
  • Dylan Blair,
  • Kenji Huff,
  • John Wisniewski,
  • Kevin S. Warner and
  • Katalin Kauser

15 December 2023

Therapeutic interventions for vascular diseases aim at achieving long-term patency by controlling vascular remodeling. The extracellular matrix (ECM) of the vessel wall plays a crucial role in regulating this process. This study introduces a novel ph...

  • Article
  • Open Access
2 Citations
3,154 Views
34 Pages

New Perspective for Using Antimicrobial and Cell-Penetrating Peptides to Increase Efficacy of Antineoplastic 5-FU in Cancer Cells

  • Nuno Vale,
  • Eduarda Ribeiro,
  • Inês Cruz,
  • Valentina Stulberg,
  • Beate Koksch and
  • Bárbara Costa

12 December 2023

This study explores the effectiveness of the antineoplastic agent 5-FU in cancer cells by leveraging the unique properties of cationic antimicrobial peptides (CAMPs) and cell-penetrating peptides (CPPs). Traditional anticancer therapies face substant...

  • Article
  • Open Access
2 Citations
3,743 Views
14 Pages

Oral Galvanism Side Effects: Comparing Alloy Ions and Galvanic Current Effects on the Mucosa-like Model

  • Natalia Chepelova,
  • Artem Antoshin,
  • Sergei Voloshin,
  • Anna Usanova,
  • Yuri Efremov,
  • Maria Makeeva,
  • Stanislav Evlashin,
  • Mikhail Stepanov,
  • Anna Turkina and
  • Peter Timashev

11 December 2023

The interaction of different dental alloys with the oral environment may cause severe side effects (e.g., burning sensation, inflammatory reactions, carcinogenesis) as a result of oral galvanism. However, the pathogenesis of side effects associated w...

  • Article
  • Open Access
4 Citations
3,027 Views
22 Pages

Model-Based Design to Enhance Neotissue Formation in Additively Manufactured Calcium-Phosphate-Based Scaffolds

  • Bingbing Liang,
  • Ehsan Sadeghian Dehkord,
  • Dorien Van Hede,
  • Mojtaba Barzegari,
  • Bruno Verlée,
  • Justine Pirson,
  • Grégory Nolens,
  • France Lambert and
  • Liesbet Geris

3 December 2023

In biomaterial-based bone tissue engineering, optimizing scaffold structure and composition remains an active field of research. Additive manufacturing has enabled the production of custom designs in a variety of materials. This study aims to improve...

  • Article
  • Open Access
3 Citations
2,771 Views
13 Pages

Evaluation of Gelatin/Hyaluronic Acid-Generated Bridging in a 3D-Printed Titanium Cage for Bone Regeneration

  • Seong-Su Park,
  • Ume Farwa,
  • Mosharraf Hossain,
  • Soobin Im and
  • Byong-Taek Lee

30 November 2023

3D-printed titanium (Ti) cages present an attractive alternative for addressing issues related to osteoporosis-induced fractures, accidental fractures, and spinal fusion surgery due to disc herniation. These Ti-based bone implants possess superior st...

  • Article
  • Open Access
5 Citations
3,102 Views
11 Pages

Titanium Biohybrid Middle Ear Prostheses: A Preliminary In Vitro Study

  • Mario Mosconi,
  • Elena Carlotto,
  • Laura Caliogna,
  • Micaela Berni,
  • Giulia Gastaldi,
  • Michele Conti,
  • Alice Maria Brancato,
  • Valentina Bina,
  • Domenico Minervini and
  • Stefano Malpede
  • + 5 authors

29 November 2023

Ossiculoplasty is a surgical operation performed to restore auditory transmission through the reconstruction of the ossicular chain using prosthetics. Tissue bioengineering has assumed a pivotal role in implementing alternatives to conventional ossic...

  • Article
  • Open Access
11 Citations
2,810 Views
20 Pages

The Effect of Silver and Samarium on the Properties of Bioglass Coatings Produced by Pulsed Laser Deposition and Spin Coating

  • Roxana Lavric,
  • Cornelia Vreme,
  • Cristina Busuioc,
  • Gabriela-Olimpia Isopencu,
  • Adrian-Ionut Nicoara,
  • Ovidiu-Cristian Oprea,
  • Daniel-Dumitru Banciu,
  • Izabela Constantinoiu and
  • Ana-Maria-Raluca Musat

28 November 2023

The current study reports the use of silver (Ag) and samarium (Sm) as dopants to improve the properties of standard bioglass in terms of biological performance. This experiment considers thin films of doped bioglass obtained by pulsed laser depositio...

  • Article
  • Open Access
3 Citations
2,202 Views
17 Pages

25 November 2023

The unique physical properties of heavy ion beams, particularly their distinctive depth–dose distribution and sharp lateral dose reduction profiles, have led to their widespread adoption in tumor therapy worldwide. However, the physical propert...

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J. Funct. Biomater. - ISSN 2079-4983Creative Common CC BY license