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Journal of Functional Biomaterials, Volume 11, Issue 1

2020 March - 20 articles

Cover Story: Drug-induced liver toxicity is one of the most common reasons for drug failure in clinical trials. Reasons for this include the low predictive power of in vivo studies, caused by interspecific differences as well as intraspecific variations. In addition, disease-related changes in the liver can also lead to changes in drug metabolism. To mimic such alterations in an in vitro model, this study aimed to develop scaffolds that represent the stiffness of healthy and fibrotic liver tissue. We observed that liver cells plated on scaffolds representing the stiffness of the healthy liver have a higher metabolic activity than cells plated on more rigid scaffolds. View this paper.
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Articles (20)

  • Feature Paper
  • Review
  • Open Access
85 Citations
14,240 Views
17 Pages

Pullulan for Advanced Sustainable Body- and Skin-Contact Applications

  • Maria-Beatrice Coltelli,
  • Serena Danti,
  • Karen De Clerck,
  • Andrea Lazzeri and
  • Pierfrancesco Morganti

The present review had the aim of describing the methodologies of synthesis and properties of biobased pullulan, a microbial polysaccharide investigated in the last decade because of its interesting potentialities in several applications. After descr...

  • Article
  • Open Access
25 Citations
6,362 Views
9 Pages

In recent years, mussel adhesive proteins have attracted much attention because they can form strong adhesive interface interactions with various substrates in a wet environment. Inspired by their catechol- and amine-based molecular structure, polydo...

  • Article
  • Open Access
7 Citations
5,430 Views
11 Pages

On-Chip Fabrication of Cell-Attached Microstructures using Photo-Cross-Linkable Biodegradable Hydrogel

  • Masaru Takeuchi,
  • Taro Kozuka,
  • Eunhye Kim,
  • Akihiko Ichikawa,
  • Yasuhisa Hasegawa,
  • Qiang Huang and
  • Toshio Fukuda

We developed a procedure for fabricating movable biological cell structures using biodegradable materials on a microfluidic chip. A photo-cross-linkable biodegradable hydrogel gelatin methacrylate (GelMA) was used to fabricate arbitrary microstructur...

  • Article
  • Open Access
13 Citations
6,066 Views
19 Pages

Development of Scaffolds with Adjusted Stiffness for Mimicking Disease-Related Alterations of Liver Rigidity

  • Marc Ruoß,
  • Silas Rebholz,
  • Marina Weimer,
  • Carl Grom-Baumgarten,
  • Kiriaki Athanasopulu,
  • Ralf Kemkemer,
  • Hanno Käß,
  • Sabrina Ehnert and
  • Andreas K. Nussler

Drug-induced liver toxicity is one of the most common reasons for the failure of drugs in clinical trials and frequent withdrawal from the market. Reasons for such failures include the low predictive power of in vivo studies, that is mainly caused by...

  • Feature Paper
  • Article
  • Open Access
5 Citations
5,127 Views
11 Pages

Temperature-responsive nanocarrier systems using external stimuli are one of the most widely investigated stimuli-responsive strategies because heat is easy and safe to use for hyperthermia and controlled drug delivery. Polyamidoamine dendron lipids...

  • Article
  • Open Access
5 Citations
5,625 Views
8 Pages

Numerical Simulation of the Posterior Malleolus Fracture with the Finite Element Method

  • Rafailia Ampla,
  • Angelo V. Vasiliadis and
  • Konstantinos Katakalos

The high demand for biodegradable implants in bone fracture fixations has dramatically increased the use of polymers for biomedical applications as well. However, the replacement of stainless steel and titanium screws by biodegradable materials repre...

  • Article
  • Open Access
9 Citations
7,385 Views
14 Pages

Low neural tissue extracellular matrix (ECM) content has led to the understudy of its effects on neural cells and tissue. Hyaluronic acid (HA) and laminin are major neural ECM components, but direct comparisons of their cellular effects could not be...

  • Review
  • Open Access
10 Citations
7,009 Views
40 Pages

Tissue engineering, with the goal of repairing or replacing damaged tissue and organs, has continued to make dramatic science-based advances since its origins in the late 1980’s and early 1990’s. Such advances are always multi-disciplinar...

  • Communication
  • Open Access
32 Citations
8,433 Views
9 Pages

Printing 3D Hydrogel Structures Employing Low-Cost Stereolithography Technology

  • Leila Samara S. M. Magalhães,
  • Francisco Eroni Paz Santos,
  • Conceição de Maria Vaz Elias,
  • Samson Afewerki,
  • Gustavo F. Sousa,
  • Andre S. A. Furtado,
  • Fernanda Roberta Marciano and
  • Anderson Oliveira Lobo

Stereolithography technology associated with the employment of photocrosslinkable, biocompatible, and bioactive hydrogels have been widely used. This method enables 3D microfabrication from images created by computer programs and allows researchers t...

  • Article
  • Open Access
5 Citations
6,596 Views
15 Pages

Mechanical and Tribological Characterization of a Dental Ceromer

  • Mariana Santos,
  • Ana Sofia Coelho,
  • Anabela Baptista Paula,
  • Carlos Miguel Marto,
  • Inês Amaro,
  • José Saraiva,
  • Manuel Marques Ferreira,
  • Pedro Antunes and
  • Eunice Carrilho

Background: Indirect restorations using composites with ceramic fillings can be an alternative to ceramic veneering and direct composite restorations for the treatment of posterior teeth. The aim of this study was the evaluation of the mechanical and...

  • Article
  • Open Access
22 Citations
5,668 Views
12 Pages

Synthesis and Properties of Zinc-Modified Hydroxyapatite

  • Daria Lytkina,
  • Anastasiya Gutsalova,
  • Dmitriy Fedorishin,
  • Natalya Korotchenko,
  • Rafik Akhmedzhanov,
  • Vladimir Kozik and
  • Irina Kurzina

Hydroxyapatites modified with metal ions are the main inorganic components of bone tissue and are approved for use as components for biocomposites and coatings for surgical implants. This study examined prototypes of functional materials for bone imp...

  • Article
  • Open Access
21 Citations
5,520 Views
13 Pages

Myristyltrimethylammonium Bromide (MYTAB) as a Cationic Surface Agent to Inhibit Streptococcus mutans Grown over Dental Resins: An In Vitro Study

  • Paola Andrea Mena Silva,
  • Isadora Martini Garcia,
  • Julia Nunes,
  • Fernanda Visioli,
  • Vicente Castelo Branco Leitune,
  • Mary Anne Melo and
  • Fabrício Mezzomo Collares

This in vitro study evaluated the effect of myristyltrimethylammonium bromide (MYTAB) on the physical, chemical, and biological properties of an experimental dental resin. The resin was formulated with dental dimetacrylate monomers and a photoinitiat...

  • Article
  • Open Access
15 Citations
4,963 Views
11 Pages

Quantitative Study of Morphological Features of Stem Cells onto Photopatterned Azopolymer Films

  • Marcella Salvatore,
  • Stefano Luigi Oscurato,
  • Marietta D’Albore,
  • Vincenzo Guarino,
  • Stefania Zeppetelli,
  • Pasqualino Maddalena,
  • Antonio Ambrosio and
  • Luigi Ambrosio

In the last decade, the use of photolithography for the fabrication of structured substrates with controlled morphological patterns that are able to interact with cells at micrometric and nanometric size scales is strongly growing. A promising simple...

  • Article
  • Open Access
20 Citations
5,540 Views
9 Pages

Cerium Dioxide Particles to Tune Radiopacity of Dental Adhesives: Microstructural and Physico-Chemical Evaluation

  • Isadora Martini Garcia,
  • Vicente Castelo Branco Leitune,
  • Antonio Shigueaki Takimi,
  • Carlos Pérez Bergmann,
  • Susana Maria Werner Samuel,
  • Mary Anne Melo and
  • Fabrício Mezzomo Collares

The insufficient radiopacity of dental adhesives applied under composite restorations makes the radiographic diagnosis of recurrent caries challenging. Consequently, the misdiagnosis may lead to unnecessary replacement of restorations. The aims of th...

  • Editorial
  • Open Access
3,945 Views
2 Pages

Acknowledgement to Reviewers of Journal of Functional Biomaterials in 2019

  • Journal of Functional Biomaterials Editorial Office

The editorial team greatly appreciates the reviewers who have dedicated their considerable time and expertise to the journal’s rigorous editorial process over the past 12 months, regardless of whether the papers are finally published or not [...]

  • Feature Paper
  • Article
  • Open Access
7 Citations
5,438 Views
16 Pages

Matrix-assisted chondrocyte transplantation (MACT) is of great interest for the treatment of patients with cartilage lesions. However, the roles of the matrix properties in modulating cartilage tissue integration during MACT recovery have not been fu...

  • Feature Paper
  • Review
  • Open Access
115 Citations
12,499 Views
26 Pages

Fabrication of Polymeric Microparticles by Electrospray: The Impact of Experimental Parameters

  • Alan Í. S. Morais,
  • Ewerton G. Vieira,
  • Samson Afewerki,
  • Ricardo B. Sousa,
  • Luzia M. C. Honorio,
  • Anallyne N. C. O. Cambrussi,
  • Jailson A. Santos,
  • Roosevelt D. S. Bezerra,
  • Josy A. O. Furtini and
  • Anderson O. Lobo
  • + 2 authors

Microparticles (MPs) with controlled morphologies and sizes have been investigated by several researchers due to their importance in pharmaceutical, ceramic, cosmetic, and food industries to just name a few. In particular, the electrospray (ES) techn...

  • Article
  • Open Access
32 Citations
9,903 Views
12 Pages

Anti-Photoaging Effect of Plant Extract Fermented with Lactobacillus buchneri on CCD-986sk Fibroblasts and HaCaT Keratinocytes

  • Yun-Mi Kang,
  • Chul-Hee Hong,
  • Sa-Haeng Kang,
  • Dong-Seok Seo,
  • Seong-Oh Kim,
  • Hoon-Yeon Lee,
  • Hyeon-Jae Sim and
  • Hyo-Jin An

Ultraviolet (UV) exposure triggers the abnormal production of reactive oxygen (ROS) species and the expression of matrix metalloproteinases (MMPs) that are responsible for photoaging. Probiotics are widely used in healthcare and for immune enhancemen...

  • Review
  • Open Access
47 Citations
9,296 Views
16 Pages

Fe-based materials have increasingly been considered for the development of biodegradable cardiovascular stents. A wide range of in vitro and in vivo studies should be done to fully evaluate their biocompatibility. In this review, we summarized and a...

  • Article
  • Open Access
5 Citations
5,378 Views
17 Pages

Physicochemical, Mechanical, and Antimicrobial Properties of Novel Dental Polymers Containing Quaternary Ammonium and Trimethoxysilyl Functionalities

  • Diane R. Bienek,
  • Anthony A. Giuseppetti,
  • Stanislav A. Frukhtbeyn,
  • Rochelle D. Hiers,
  • Fernando L. Esteban Florez,
  • Sharukh S. Khajotia and
  • Drago Skrtic

The aims of this study were to evaluate the physicochemical and mechanical properties, antimicrobial (AM) functionality, and cytotoxic potential of novel dental polymers containing quaternary ammonium and trimethoxysilyl functionalities (e.g., N-(2-(...

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J. Funct. Biomater. - ISSN 2079-4983