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Printing 3D Hydrogel Structures Employing Low-Cost Stereolithography Technology

LIMAV–Interdisciplinary Laboratory for Advanced Materials, BioMatLab, Materials Science and Engineering Graduate Program, UFPI–Federal University of Piauí, Teresina 64049-550, Brazil
Department of Physics, UFPI–Federal University of Piauí, Teresina 64049-550, Brazil
Biomedical Engineering Graduate Program, University of Brazil, São Paulo 08230-030, Brazil
Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham & Women´s Hospital, Cambridge, MA 02139, USA
Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, MIT, Cambridge, MA 02139, USA
Author to whom correspondence should be addressed.
J. Funct. Biomater. 2020, 11(1), 12;
Received: 17 December 2019 / Revised: 12 February 2020 / Accepted: 20 February 2020 / Published: 22 February 2020
(This article belongs to the Special Issue Fibrous Scaffolds for Tissue Engineering Application)
Stereolithography technology associated with the employment of photocrosslinkable, biocompatible, and bioactive hydrogels have been widely used. This method enables 3D microfabrication from images created by computer programs and allows researchers to design various complex models for tissue engineering applications. This study presents a simple and fast home-made stereolithography system developed to print layer-by-layer structures. Polyethylene glycol diacrylate (PEGDA) and gelatin methacryloyl (GelMA) hydrogels were employed as the photocrosslinkable polymers in various concentrations. Three-dimensional (3D) constructions were obtained by using the stereolithography technique assembled from a commercial projector, which emphasizes the low cost and efficiency of the technique. Lithium phenyl-2,4,6-trimethylbenzoyl phosphonate (LAP) was used as a photoinitiator, and a 404 nm laser source was used to promote the crosslinking. Three-dimensional and vascularized structures with more than 5 layers and resolutions between 42 and 83 µm were printed. The 3D printed complex structures highlight the potential of this low-cost stereolithography technique as a great tool in tissue engineering studies, as an alternative to bioprint miniaturized models, simulate vital and pathological functions, and even for analyzing the actions of drugs in the human body. View Full-Text
Keywords: stereolithography; bioprinting; 3D printing; hydrogels; GelMA; PEGDA stereolithography; bioprinting; 3D printing; hydrogels; GelMA; PEGDA
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MDPI and ACS Style

Magalhães, L.S.S.M.; Santos, F.E.P.; Elias, C.d.M.V.; Afewerki, S.; Sousa, G.F.; Furtado, A.S.A.; Marciano, F.R.; Lobo, A.O. Printing 3D Hydrogel Structures Employing Low-Cost Stereolithography Technology. J. Funct. Biomater. 2020, 11, 12.

AMA Style

Magalhães LSSM, Santos FEP, Elias CdMV, Afewerki S, Sousa GF, Furtado ASA, Marciano FR, Lobo AO. Printing 3D Hydrogel Structures Employing Low-Cost Stereolithography Technology. Journal of Functional Biomaterials. 2020; 11(1):12.

Chicago/Turabian Style

Magalhães, Leila Samara S. M., Francisco Eroni Paz Santos, Conceição de Maria Vaz Elias, Samson Afewerki, Gustavo F. Sousa, Andre S. A. Furtado, Fernanda Roberta Marciano, and Anderson Oliveira Lobo. 2020. "Printing 3D Hydrogel Structures Employing Low-Cost Stereolithography Technology" Journal of Functional Biomaterials 11, no. 1: 12.

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