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Journal of Functional Biomaterials, Volume 10, Issue 3

2019 September - 17 articles

Cover Story: Thermogelling biomaterials have application potentials as injectable drug depots or 3D bioprinting. Here, we report a new thermogelling polymer based on a poly(2-oxazoline) ABA-type triblock copolymer. Their aqueous solutions were investigated at different concentrations (1–20 wt.%) and in the temperature range of 5–80°C. Only 20 wt.% solution showed thermogelation. Therefore, the rheological and viscoelastic properties were determined using strain and temperature sweeps. The hydrogel exhibited low toxicity against Calu-3 and HEK cells even at high polymer concentrations up to 100 g/L. Investigation of the yields stress showed, that the 3D printing ability is low and needs further adjustments. View this paper.
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Articles (17)

  • Article
  • Open Access
29 Citations
7,469 Views
11 Pages

Striking Differences in Platelet Distribution between Advanced-Platelet-Rich Fibrin and Concentrated Growth Factors: Effects of Silica-Containing Plastic Tubes

  • Tetsuhiro Tsujino,
  • Hideo Masuki,
  • Masayuki Nakamura,
  • Kazushige Isobe,
  • Hideo Kawabata,
  • Hachidai Aizawa,
  • Taisuke Watanabe,
  • Yutaka Kitamura,
  • Hajime Okudera and
  • Tomoyuki Kawase
  • + 2 authors

17 September 2019

Compared with platelet-rich plasma, the preparation of platelet-rich fibrin (PRF) is simple and has not been overly modified. However, it was recently demonstrated that centrifugation conditions influence the composition of PRF and that silica microp...

  • Article
  • Open Access
25 Citations
6,721 Views
18 Pages

16 September 2019

The controlled release or delivery of proteins encapsulated in micro/nanospheres is an emerging strategy in regenerative medicine. For this, micro/nanospheres made from alginate have drawn considerable attention for the use as a protein delivery devi...

  • Article
  • Open Access
2 Citations
6,004 Views
15 Pages

Silk-Based Therapeutics Targeting Pseudomonas aeruginosa

  • Tina B. McKay,
  • Rachael N. Parker,
  • Morgan J. Hawker,
  • Meghan McGill and
  • David L. Kaplan

13 September 2019

Pseudomonas aeruginosa (P. aeruginosa) infections may lead to severe damage of the cornea, mucosa, and skin. The highly aggressive nature of P. aeruginosa and the rise in multi-drug resistance, particularly in nosocomial settings, lead to an increase...

  • Article
  • Open Access
7 Citations
6,954 Views
8 Pages

Study of an Additional Layer of Cement Mantle Hip Joints for Reducing Cracks

  • J. Jamari,
  • Eko Saputra,
  • Iwan Budiwan Anwar and
  • Emile van der Heide

Failure of the cement mantle in total hip arthroplasty is not a simple phenomenon. Cracking, which can be caused by crack initiation and repeated loading, can cause loosening of the acetabular liner component. A previous study showed that addition of...

  • Article
  • Open Access
22 Citations
7,696 Views
12 Pages

Production of a Recombinant Non-Hydroxylated Gelatin Mimetic in Pichia pastoris for Biomedical Applications

  • Pia Gellermann,
  • Caroline Schneider-Barthold,
  • Svenja Nicolin Bolten,
  • Ethan Overfelt,
  • Thomas Scheper and
  • Iliyana Pepelanova

Proteins derived from the natural extracellular matrix like collagen or gelatin are common in clinical research, where they are prized for their biocompatibility and bioactivity. Cells are able to adhere, grow and remodel scaffolds based on these mat...

  • Feature Paper
  • Article
  • Open Access
18 Citations
6,253 Views
15 Pages

Effect of Melt-Derived Bioactive Glass Particles on the Properties of Chitosan Scaffolds

  • Hamasa Faqhiri,
  • Markus Hannula,
  • Minna Kellomäki,
  • Maria Teresa Calejo and
  • Jonathan Massera

This study reports on the processing of three-dimensional (3D) chitosan/bioactive glass composite scaffolds. On the one hand, chitosan, as a natural polymer, has suitable properties for tissue engineering applications but lacks bioactivity. On the ot...

  • Technical Note
  • Open Access
8 Citations
6,409 Views
12 Pages

Measurement of Adhesion of Sternal Wires to a Novel Bioactive Glass-Based Adhesive

  • Varinder Pal Singh Sidhu,
  • Mark R. Towler and
  • Marcello Papini

Stainless steel wires are the standard method for sternal closure because of their strength and rigidity, the simplicity of the process, and the short healing time that results from their application. Despite this, problems still exist with sternal s...

  • Article
  • Open Access
39 Citations
8,064 Views
16 Pages

The synthesis and characterization of an ABA triblock copolymer based on hydrophilic poly(2-methyl-2-oxazoline) (pMeOx) blocks A and a modestly hydrophobic poly(2-iso-butyl-2-oxazoline) (piBuOx) block B is described. Aqueous polymer solutions were pr...

  • Article
  • Open Access
37 Citations
9,555 Views
10 Pages

Transparent composite hydrogel in the form of a contact lens made from poly(vinyl alcohol) (PVA) and cellulose nanocrystals (CNCs) was subjected to in vitro biocompatibility evaluation with human corneal epithelial cells (HCE-2 cells). The cell respo...

  • Review
  • Open Access
273 Citations
16,842 Views
20 Pages

Stimuli-Responsive Drug Release from Smart Polymers

  • Carlos M. Wells,
  • Michael Harris,
  • Landon Choi,
  • Vishnu Priya Murali,
  • Fernanda Delbuque Guerra and
  • J. Amber Jennings

Over the past 10 years, stimuli-responsive polymeric biomaterials have emerged as effective systems for the delivery of therapeutics. Persistent with ongoing efforts to minimize adverse effects, stimuli-responsive biomaterials are designed to release...

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J. Funct. Biomater. - ISSN 2079-4983