Special Issue "Innovative Biomaterial Solutions for Translational Tissue Engineering and Regenerative Medicine"

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: closed (31 December 2019).

Special Issue Editor

Prof. Ziyad S. Haidar
E-Mail Website
Guest Editor
Professor and Director BioMAT’X R&D&I Group, Scientific Director – Research, Development and Innovation, Faculty of Dentistry, Cross Appointment – BioMedicine Doctoral Program, Faculty of Medicine, Universidad de los Andes, Santiago, Chile
Interests: Patient-oriented development and evaluation of bionanotechnology; biopolymers; bioceramics and drug delivery systems for the repair; restoration, reconstruction and regeneration of challenging craniofacial and orthopaedic defects
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Special Issue Information

Dear Colleagues.

It is my privilege to invite you to submit a manuscript for an upcoming Special Issue of the Journal of Functional Biomaterials, entitled “Innovative Biomaterial Solutions for Translational Tissue Engineering and Regenerative Medicine”.

Innovative tissue engineering and regenerative medicine solutions that incorporate nanobiotechnology, advanced biomaterials, computer assistance, three-dimensional printing, and robotic systems offer extensive potential for augmenting and improving the functional and esthetic cranio-maxillo-facial and oro-dental health profile of patients.

A good example, perhaps, is nanodentistry, clearly multidisciplinary and interdisciplinary, building on existing knowledge and accruing expertise in different scientific and technological fields, seeking persistent refinement of traditional approaches, via the development and/or incorporation of advanced functional biomaterials, cell-/gene-/drug-delivery systems, new tools, and pharmacological formulations to improve overall oro-dental practice and care, which is slowly-evolving yet expected to provide dentists with more precision-made and tailored materials, drugs, and equipment, by which safety, esthetics, function, and patient compliance are enhanced. Due to the complex nature of such “outside-the-box” oro-dental and cranio-maxillo-facial (head and neck) healthcare-related engineering technologies, they have attracted experts from physics, chemistry, biology, materials science, pharmaceutics, robotics, and bioengineering, as well as industry.

This Special Issue is dedicated to the state-of-the-art in oro-dental and cranio-maxillo-facial tissue engineering (restoration, replacement, reconstruction, regeneration and repair)-related topics and emphasizes the bionanotechnology-, functional biomaterial-, and three-dimensional-related topics for innovative alternative solution design, characterization, evaluation and optimization. Hence, the focus is on demonstrating physico-chemico-mechanical/rheological, cellular, histomorphometrical and immunohistochemical parameters and safety (cyto-/bio-compatibility) and efficacy (pre-clinical and clinical) characteristics of functional biomaterials for tissue engineering and regenerative medicine.

Through a collection of original papers, this Special Issue aims to exhibit the latest state-of-the-art in R&D&i ideas, concepts, findings, achievements, and future projections and promote awareness of this rapidly-evolving and enabling multidisciplinary technology, thereby encouraging bridging the gap between medicine, dentistry, pharmacy, material sciences and engineering (including sub-specialities, extending to the head and neck, orthopaedics, oncology, amongst others) for research collaboration across the fields to address the critical and urgent bio-dental/bio-medical concerns. Clinicians and researchers are invited to contribute with their original evidence-based articles, as well as critical literature review manuscripts, summarizing the most recent and exciting innovative developments.

Potential topics include, but are not limited to, the following:

  • Biomimetic nanobiomaterials
  • Bioceramics and bioglasses
  • Exosomes and multi-vesicular bodies as drug carriers and delivery vehicles
  • Functional scaffolds for craniomaxillofacial tissue engineering applications
  • Stimuli-responsive biomaterials for tissue engineering
  • Smart and multifunctional biomaterials for tissue engineering
  • Functional biomaterials and cell/tissue–material interactions
  • Natural polymer-based biomaterials for tissue engineering
  • Nanodentistry and the role of nanobiotechnology in biomaterials, pharmaceutics, and biodental tissue engineering
  • Image-guided surgery and medico-dental robotics
  • 3-D printing and surgical engineering in the craniomaxillofacial complex
  • Computer-aided planning and intraoperative navigation in dental implantology and craniomaxillofacial surgery
  • Biomaterial fabrication and evaluation techniques: freeze drying, electrospinning, etc.
  • Drug/Gene delivery and Cell therapy
  • Injectable biomaterials for pharmaceutic agent (cell, gene, drug) delivery
  • Cosmetology and orofacial surgery
  • Microfabrication approaches for engineering functional tissues
  • Platelet concentrates and platelet-rich fibrin for tissue repair
  • Translational functional biomaterials: bench-top to bed-side/market

Prof. Ziyad S. Haidar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • tissue engineering
  • regenerative medicine
  • bionanotechnology
  • biopolymers
  • bioceramics
  • drug delivery
  • restoration
  • orthopaedic

Published Papers (1 paper)

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Open AccessArticle
Repair of Orbital Post-Traumatic Wall Defects by Custom-Made TiNi Mesh Endografts
J. Funct. Biomater. 2019, 10(3), 27; https://doi.org/10.3390/jfb10030027 - 27 Jun 2019
Repairs of orbital post-traumatic and extensive malignant defects remain a major surgical challenge, in view of follow-up outcomes. Incorrect surgical management of injured facial structures results in cosmetic, ophthalmic, and social aftereffects. A custom-made knitted TiNi-based mesh (KTNM) endograft was employed to overcome [...] Read more.
Repairs of orbital post-traumatic and extensive malignant defects remain a major surgical challenge, in view of follow-up outcomes. Incorrect surgical management of injured facial structures results in cosmetic, ophthalmic, and social aftereffects. A custom-made knitted TiNi-based mesh (KTNM) endograft was employed to overcome post-surgical complications and post-resected lesions of the orbital area. Preoperative high-resolution computed tomography (CT) imaging and CAD modelling were used to design the customized KTNM in each case. Twenty-five patients underwent surgery utilizing the suggested technique, from 2014 to 2019. In all documented cases, resolution of the ophthalmic malfunction was noted in the early period. Follow-up observation evidenced no relapsed enophthalmos, hypoglobus, or diplopia as late complications. The findings emanating from our clinical observations allow us to claim that the KTNM indicated a high level of biocompatibility. It is simply modified intraoperatively to attach any desired shape/size for implantation and can also be screw-fixed, providing a good supporting ability. The KTNM precisely renders orbitozygomatic outlines and orbital floor, thus recovering the anatomical structure, and is regarded as an attractive alternative to Ti-based meshes and plates. Additionally, we report one of the studied cases, where good functional and cosmetic outcomes have been achieved. Full article
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