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Temperature-Dependent Rheological and Viscoelastic Investigation of a Poly(2-methyl-2-oxazoline)-b-poly(2-iso-butyl-2-oxazoline)-b-poly(2-methyl-2-oxazoline)-Based Thermogelling Hydrogel

1
Polymer Functional Materials, Chair for Advanced Materials Synthesis, Department of Chemistry and Pharmacy and Bavarian Polymer Institute, Julius-Maximilians-University Würzburg, 97084 Würzburg, Germany
2
Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Trida T. Bati 5678, 760 01 Zlin, Czech Republic
3
Institute of Pharmacy and Food Chemistry, Julius-Maximilians-University Würzburg, Am Hubland, 97074 Würzburg, Germany
*
Author to whom correspondence should be addressed.
J. Funct. Biomater. 2019, 10(3), 36; https://doi.org/10.3390/jfb10030036
Received: 14 May 2019 / Revised: 1 July 2019 / Accepted: 30 July 2019 / Published: 7 August 2019
(This article belongs to the Special Issue Smart Biomaterials)
The synthesis and characterization of an ABA triblock copolymer based on hydrophilic poly(2-methyl-2-oxazoline) (pMeOx) blocks A and a modestly hydrophobic poly(2-iso-butyl-2-oxazoline) (piBuOx) block B is described. Aqueous polymer solutions were prepared at different concentrations (1–20 wt %) and their thermogelling capability using visual observation was investigated at different temperatures ranging from 5 to 80 °C. As only a 20 wt % solution was found to undergo thermogelation, this concentration was investigated in more detail regarding its temperature-dependent viscoelastic profile utilizing various modes (strain or temperature sweep). The prepared hydrogels from this particular ABA triblock copolymer have interesting rheological and viscoelastic properties, such as reversible thermogelling and shear thinning, and may be used as bioink, which was supported by its very low cytotoxicity and initial printing experiments using the hydrogels. However, the soft character and low yield stress of the gels do not allow real 3D printing at this point. View Full-Text
Keywords: amphiphilic block copolymer; poly(2-oxazoline); viscoelasticity; thermoresponsive hydrogel; cytocompatibility amphiphilic block copolymer; poly(2-oxazoline); viscoelasticity; thermoresponsive hydrogel; cytocompatibility
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Lübtow, M.M.; Mrlik, M.; Hahn, L.; Altmann, A.; Beudert, M.; Lühmann, T.; Luxenhofer, R. Temperature-Dependent Rheological and Viscoelastic Investigation of a Poly(2-methyl-2-oxazoline)-b-poly(2-iso-butyl-2-oxazoline)-b-poly(2-methyl-2-oxazoline)-Based Thermogelling Hydrogel. J. Funct. Biomater. 2019, 10, 36.

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