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Open AccessReview

Stimuli-Responsive Drug Release from Smart Polymers

Department of Biomedical Engineering, The University of Memphis, Memphis, TN 38152, USA
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Author to whom correspondence should be addressed.
J. Funct. Biomater. 2019, 10(3), 34; https://doi.org/10.3390/jfb10030034
Received: 28 May 2019 / Revised: 24 July 2019 / Accepted: 26 July 2019 / Published: 31 July 2019
(This article belongs to the Special Issue Smart Biomaterials)
Over the past 10 years, stimuli-responsive polymeric biomaterials have emerged as effective systems for the delivery of therapeutics. Persistent with ongoing efforts to minimize adverse effects, stimuli-responsive biomaterials are designed to release in response to either chemical, physical, or biological triggers. The stimuli-responsiveness of smart biomaterials may improve spatiotemporal specificity of release. The material design may be used to tailor smart polymers to release a drug when particular stimuli are present. Smart biomaterials may use internal or external stimuli as triggering mechanisms. Internal stimuli-responsive smart biomaterials include those that respond to specific enzymes or changes in microenvironment pH; external stimuli can consist of electromagnetic, light, or acoustic energy; with some smart biomaterials responding to multiple stimuli. This review looks at current and evolving stimuli-responsive polymeric biomaterials in their proposed applications. View Full-Text
Keywords: stimuli-responsiveness; drug release; drug delivery; thermo-responsive materials; enzyme-responsive materials; pH-responsive materials; shape-memory materials stimuli-responsiveness; drug release; drug delivery; thermo-responsive materials; enzyme-responsive materials; pH-responsive materials; shape-memory materials
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MDPI and ACS Style

Wells, C.M.; Harris, M.; Choi, L.; Murali, V.P.; Guerra, F.D.; Jennings, J.A. Stimuli-Responsive Drug Release from Smart Polymers. J. Funct. Biomater. 2019, 10, 34.

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