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Journal of Clinical Medicine, Volume 9, Issue 11

November 2020 - 409 articles

Cover Story: Perturbations in mitochondrial dysfunction play significant role in the pathogenesis of HF. Pathophysiological mechanisms leading to mitochondrial dysfunction in HF are numerous and range from changes in morphology and dynamics; to altered endoplasmic reticulum (ER)-mitochondrial (mt) tethering due to altered signaling and calcium cycling at the ER-mt interphase; enhanced mt-calcium uptake and overload; increased reactive oxygen species and apoptosis; and decreased mt-biogenesis, and oxidative capacity. Investigational drugs targeting specific areas of mt-dysfunction are being investigated. There remain an unmet need to explore molecular mechanisms modulating the multiplicity of mt-dysfunction in HF for better effective therapeutic interventions. View this paper
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Articles (409)

  • Article
  • Open Access
12 Citations
12,293 Views
10 Pages

Exploring the Role of Caffeine Use in Adult-ADHD Symptom Severity of US Army Soldiers

  • Giada Cipollone,
  • Philip Gehrman,
  • Corrado Manni,
  • Alessandro Pallucchini,
  • Angelo G. I. Maremmani,
  • Laura Palagini,
  • Giulio Perugi and
  • Icro Maremmani

23 November 2020

There is a growing trend of using energy drinks and caffeinated beverages to improve cognitive performance that is widespread and well-studied among children and teenagers with Attention Deficit Hyperactive Disorder (ADHD), but little is known about...

  • Article
  • Open Access
13 Citations
3,774 Views
9 Pages

Changes in the Use of Fresh-Frozen Plasma Transfusions in Preterm Neonates: A Single Center Experience

  • Nina A. M. Houben,
  • Lisanne E. Heeger,
  • Simon J. Stanworth,
  • Helen V. New,
  • Johanna G. van der Bom,
  • Suzanne Fustolo-Gunnink and
  • Enrico Lopriore

23 November 2020

The aim of this study was to evaluate changes in the use of fresh-frozen plasma (FFP) transfusions and the use of clotting tests in preterm neonates in our center over the past two decades. In this retrospective cohort analysis, we included all conse...

  • Article
  • Open Access
3 Citations
2,841 Views
13 Pages

Investigation of Vestibular Function in Adult Patients with Gitelman Syndrome: Results of an Observational Study

  • Mihaela Alexandru,
  • Marie Courbebaisse,
  • Christine Le Pajolec,
  • Adeline Ménage,
  • Jean-François Papon,
  • Rosa Vargas-Poussou,
  • Jérôme Nevoux and
  • Anne Blanchard

23 November 2020

Gitelman syndrome (GS) is a rare salt-losing tubulopathy caused by an inactivating mutation in the SLC12A3 gene, encoding the thiazide-sensitive sodium chloride cotransporter (NCC). Patients with GS frequently complain of vertigo, usually attributed...

  • Article
  • Open Access
12 Citations
3,781 Views
11 Pages

The Association between Tear Film Thickness as Measured with OCT and Symptoms and Signs of Dry Eye Disease: A Pooled Analysis of 6 Clinical Trials

  • Gerhard Garhöfer,
  • Valentin Aranha Dos Santos,
  • Hannes Stegmann,
  • Doreen Schmidl,
  • Narine Adzhemian,
  • René M. Werkmeister and
  • Leopold Schmetterer

23 November 2020

Purpose: To determine the association between tear film thickness (TFT) as measured with ultra-high resolution optical coherence tomography (UHR-OCT) and signs and symptoms of dry eye disease (DED). Methods: A total of 450 eyes from 225 patients with...

  • Article
  • Open Access
4 Citations
2,953 Views
10 Pages

23 November 2020

Objective: To investigate the effects of intravitreal bevacizumab (IVB) injection before PRP on the prevention of macular edema (ME) in patients with PDR. Methods: This retrospective observational study included patients diagnosed with PDR treated by...

  • Article
  • Open Access
5 Citations
2,887 Views
9 Pages

Uterus Preservation in Case of Vaginal Prolapse Surgery Acts as a Protector against Postoperative Urinary Retention

  • Christine Bekos,
  • Raffaela Morgenbesser,
  • Heinz Kölbl,
  • Heinrich Husslein,
  • Wolfgang Umek,
  • Klaus Bodner and
  • Barbara Bodner-Adler

23 November 2020

Background: The aim of this study was to identify clinical risk factors for increased post-void residual (PVR) volumes in patients undergoing vaginal prolapse surgery and to find out whether uterus preservation or prolapse hysterectomy influences the...

  • Editorial
  • Open Access
10 Citations
3,950 Views
6 Pages

Overcoming the Use of Mechanical Restraints in Psychiatry: A New Challenge in the Everyday Clinical Practice at the Time of COVID-19

  • Domenico De Berardis,
  • Antonio Ventriglio,
  • Michele Fornaro,
  • Federica Vellante,
  • Giovanni Martinotti,
  • Silvia Fraticelli and
  • Massimo Di Giannantonio

23 November 2020

Restraining interventions, which comprise physical (PR) and mechanical restraint (MR), have a long history in mental health services [...]

  • Article
  • Open Access
8 Citations
4,522 Views
11 Pages

Effectiveness and Safety of Topical Chlorhexidine and Vitamin E TPGS in the Treatment of Acanthamoeba Keratitis: A Survey on 29 Cases

  • Ciro Caruso,
  • Daniela Eletto,
  • Michele Rinaldi,
  • Luigi Pacente,
  • Salvatore Troisi,
  • Francesco Semeraro,
  • Roberto dell’Omo and
  • Ciro Costagliola

23 November 2020

This study aimed to test the effectiveness of a solution of chlorhexidine (CHX) and D-α-tocopheryl polyethylene glycol succinate (Vitamin E TPGS or TPGS) in the treatment of Acanthamoeba keratitis (AK) via a prospective, interventional case ser...

  • Review
  • Open Access
39 Citations
5,904 Views
14 Pages

Drug Repurposing Approaches to Combating Viral Infections

  • Jay Trivedi,
  • Mahesh Mohan and
  • Siddappa N. Byrareddy

23 November 2020

Development of novel antiviral molecules from the beginning costs an average of $350 million to $2 billion per drug, and the journey from the laboratory to the clinic takes about 10–15 years. Utilization of drug repurposing approaches has gener...

  • Article
  • Open Access
20 Citations
3,460 Views
11 Pages

Automated CT Analysis of Major Forms of Interstitial Lung Disease

  • Marlee S. Crews,
  • Brian J. Bartholmai,
  • Ayodeji Adegunsoye,
  • Justin M. Oldham,
  • Steven M. Montner,
  • Ronald A. Karwoski,
  • Aliya N. Husain,
  • Rekha Vij,
  • Imre Noth and
  • Mary E. Strek
  • + 1 author

23 November 2020

This study aimed to determine diagnostic and prognostic differences in major forms of interstitial lung disease using quantitative CT imaging. A retrospective study of 225 subjects with a multidisciplinary diagnosis of idiopathic pulmonary fibrosis (...

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J. Clin. Med. - ISSN 2077-0383