Table of Contents
J. Clin. Med., Volume 6, Issue 1 (January 2017)
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Cover Story (view full-size image) In this study we present a comprehensive review of the use of liquid biopsy or test for circulating [...] Read more. In this study we present a comprehensive review of the use of liquid biopsy or test for circulating tumor DNA in blood and other bodily fluids in many cancers. We present an extensive analysis of the concordance rates with tissue biopsy in common cancers like breast, lung, colon, and prostate and include a robust review of the mechanisms of shedding of this tumor DNA. We aim to educate the modern internist on the state of the field in this rapidly evolving area of cancer diagnostics and precision therapy where cancers are treated often based on mutations which can be monitored throughout the course of the disease with advances in liquid biopsy. Potential uses of liquid biopsy include diagnosis of cancers in high- risk individuals, monitoring for metastases before radiologic evidence, monitoring of treatment response, and detection of new targetable mutations. View the paper here.