Biological and Clinical Aspects of TGF-beta in Carcinogenesis

Dear Colleagues,

TGF-beta is a multipotent cytokine essential for normal development and immunity. Cells have complex molecular machineries to modulate the TGF-beta signaling on multiple levels. Deregulation of these safety mechanisms and general overexpression of TGF-beta has been frequently encountered in cancer. Indeed, TGF-beta has been associated to nearly all hallmarks of cancer progression. However and despite multiple advances, the mechanistic understanding TGF-beta biology in cancer is still difficult and confusing. Tumor-promoting and tumor-suppressive functions have both been observed in cell, time and context dependent manner. Despite these major gaps in our knowledge, numerous clinical trials have been started and completed with TGF-beta inhibitors yielding rather mixed results. The present Special Issue aims to outline our newest understanding of TGF-beta biological function in cancer as well as to review the most relevant clinical trials where TGF-beta served as a target. Our integrative understanding of both aspects should contribute to a clearer picture concerning the open questions and clinical perspectives of TGF-beta in carcinogenesis.

Dr. Andrei Turtoi
Guest Editor

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