Special Issue "B Cells in Autoimmunity"
Deadline for manuscript submissions: closed (31 August 2016).
B cells play an important role in the immune response by antigen presentation and cytokine and antibody production. Unfortunately, the same functional attributes of B cells that are indispensable for protection against pathogens can also contribute to the etiology of certain autoimmune diseases. Conversely, several studies also suggest regulatory potential of B cells and highlight their role in controlling autoimmunity. Thus, it is evident that B cells can play a dual role in autoimmune diseases. It is likely that different subsets of B cells are either pathogenic or regulatory in nature. Although an active area of research, it is still not clear when, how and which subsets of B cells play one or the other role in the context of different autoimmune diseases. Of clinical relevance, therapeutic B cell depletion strategies are increasingly being used for the management of some autoimmune diseases. Although, they show efficacy in some clinical trials, adverse autoimmune reactions are also reported in some patients undergoing these therapy. Thus, it is very important to know when and how different subsets of B cells play either a pathogenic or a regulatory role, in the context of different autoimmune diseases, so that they can be precisely targeted for therapeutic purpose. Please join us in presenting this special issue focused on understanding the differential roles and mechanisms of action of different B cell subsets in autoimmunity that would be helpful for developing safe and effective B cell-targeted therapies.
Dr. Bonnie N. Dittel
Dr. Avijit Ray
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Pathogenic B cell
- Regulatory B cell
- B cell-targeted therapy
- B cell depletion.