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Mammary Gland Involution Provides a Unique Model to Study the TGF-β Cancer Paradox
Open AccessFeature PaperReview

TGF-β Signaling in Gastrointestinal Cancers: Progress in Basic and Clinical Research

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Research Program for Omics-based Medical Science, Division of Integrated Oncology Research, Gunma University Initiative for Advanced Research, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan
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Department of Molecular Pharmacology and Oncology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan
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Author to whom correspondence should be addressed.
Academic Editor: Andrei Turtoi
J. Clin. Med. 2017, 6(1), 11; https://doi.org/10.3390/jcm6010011
Received: 17 October 2016 / Revised: 31 December 2016 / Accepted: 16 January 2017 / Published: 18 January 2017
(This article belongs to the Special Issue Biological and Clinical Aspects of TGF-beta in Carcinogenesis)
Transforming growth factor (TGF)-β superfamily proteins have many important biological functions, including regulation of tissue differentiation, cell proliferation, and migration in both normal and cancer cells. Many studies have reported that TGF-β signaling is associated with disease progression and therapeutic resistance in several cancers. Similarly, TGF-β-induced protein (TGFBI)—a downstream component of the TGF-β signaling pathway—has been shown to promote and/or inhibit cancer. Here, we review the state of basic and clinical research on the roles of TGF-β and TGFBI in gastrointestinal cancers. View Full-Text
Keywords: TGF-β signaling; TGFBI; gastrointestinal cancer; EMT; tumor promoter; tumor suppressor TGF-β signaling; TGFBI; gastrointestinal cancer; EMT; tumor promoter; tumor suppressor
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Yokobori, T.; Nishiyama, M. TGF-β Signaling in Gastrointestinal Cancers: Progress in Basic and Clinical Research. J. Clin. Med. 2017, 6, 11.

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