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Journal of Clinical Medicine, Volume 5, Issue 12

December 2016 - 12 articles

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Articles (12)

  • Review
  • Open Access
247 Citations
18,190 Views
24 Pages

The Dual Role of Neutrophils in Inflammatory Bowel Diseases

  • Odile Wéra,
  • Patrizio Lancellotti and
  • Cécile Oury

17 December 2016

Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, are characterised by aberrant immunological responses leading to chronic inflammation without tissue regeneration. These two diseases are considered distinct entitie...

  • Article
  • Open Access
43 Citations
17,764 Views
27 Pages

Treatment of Post-Traumatic Stress Disorder Nightmares at a Veterans Affairs Medical Center

  • Mark B. Detweiler,
  • Bhuvaneshwar Pagadala,
  • Joseph Candelario,
  • Jennifer S. Boyle,
  • Jonna G. Detweiler and
  • Brian W. Lutgens

16 December 2016

The effectiveness of medications for PTSD in general has been well studied, but the effectiveness of medicatio.ns prescribed specifically for post-traumatic stress disorder (PTSD) nightmares is less well known. This retrospective chart review examine...

  • Review
  • Open Access
11 Citations
6,626 Views
9 Pages

13 December 2016

The use of assistive technology and telemedicine is likely to continue to shape our medical practice in the future, notably in the field of sleep medicine, especially within developed countries. Currently, the number of people suffering from obstruct...

  • Review
  • Open Access
18 Citations
9,184 Views
17 Pages

Bronchiectasis in the Last Five Years: New Developments

  • Jun Keng Khoo,
  • Victoria Venning,
  • Conroy Wong and
  • Lata Jayaram

8 December 2016

Bronchiectasis, a chronic lung disease characterised by cough and purulent sputum, recurrent infections, and airway damage, is associated with considerable morbidity and mortality. To date, treatment options have been limited to physiotherapy to clea...

  • Review
  • Open Access
13 Citations
6,320 Views
15 Pages

6 December 2016

Significant advances in the understanding of the pathophysiology of pulmonary arterial hypertension over the past two decades have led to the development of targeted therapies and improved patient outcomes. Currently, a broad armamentarium of pulmona...

  • Review
  • Open Access
160 Citations
23,273 Views
20 Pages

5 December 2016

The diaphragm is the main inspiratory muscle, and its dysfunction can lead to significant adverse clinical consequences. The aim of this review is to provide clinicians with an overview of the main causes of uni- and bi-lateral diaphragm dysfunction,...

  • Review
  • Open Access
28 Citations
6,185 Views
12 Pages

30 November 2016

TGF-β induces complicated and even opposite responses in numerous biological processes, e.g., tumor suppression in pre-malignant cells and metastasis promotion in cancer cells. However, the cellular contextual determinants of these different TGF-β ro...

  • Review
  • Open Access
16 Citations
8,262 Views
10 Pages

Proteinase-Activated Receptor 2 Is a Novel Regulator of TGF-β Signaling in Pancreatic Cancer

  • David Witte,
  • Franziska Zeeh,
  • Thomas Gädeken,
  • Frank Gieseler,
  • Bernhard H. Rauch,
  • Utz Settmacher,
  • Roland Kaufmann,
  • Hendrik Lehnert and
  • Hendrik Ungefroren

30 November 2016

TGF-β has a dual role in tumorigenesis, acting as a tumor suppressor in normal cells and in the early stages of tumor development while promoting carcinogenesis and metastasis in advanced tumor stages. The final outcome of the TGF-β response is deter...

  • Case Report
  • Open Access
3 Citations
5,685 Views
8 Pages

Burkholderia contaminans Colonization from Contaminated Liquid Docusate (Colace) in a Immunocompetent Adult with Legionnaire’s Disease: Infection Control Implications and the Potential Role of Candida pellucosa

  • Burke A. Cunha,
  • John Gian,
  • Bertamaria Dieguez,
  • Elsa Santos-Cruz,
  • Daniela Matassa,
  • Steve Gerson,
  • Pat Daniels,
  • Carlos Rosales and
  • Rodger P. Silletti

30 November 2016

Objective: B. contaminans was cultured from respiratory secretions and liquid docusate (Colace) in a Neurosurgical Intensive Care Unit (NICU) patient with community-acquired Legionnaire’s disease but not from another bottle given to the patient. Unex...

  • Article
  • Open Access
27 Citations
7,164 Views
13 Pages

Hyaluronic Acid Gel-Based Scaffolds as Potential Carrier for Growth Factors: An In Vitro Bioassay on Its Osteogenic Potential

  • Masako Fujioka-Kobayashi,
  • Benoit Schaller,
  • Eizaburo Kobayashi,
  • Maria Hernandez,
  • Yufeng Zhang and
  • Richard J. Miron

30 November 2016

Hyaluronic acid (HA) has been utilized for a variety of regenerative medical procedures due to its widespread presence in connective tissue and perceived biocompatibility. The aim of the present study was to investigate HA in combination with recombi...

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J. Clin. Med. - ISSN 2077-0383