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Open AccessFeature PaperReview

Mechanisms of Regulatory B cell Function in Autoimmune and Inflammatory Diseases beyond IL-10

1
Blood Center of Wisconsin, Blood Research Institute, Milwaukee, WI 53226, USA
2
Oncology Discovery, AbbVie Inc., North Chicago, IL 60064, USA
3
Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI 53226, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Emmanuel Andrès
J. Clin. Med. 2017, 6(1), 12; https://doi.org/10.3390/jcm6010012
Received: 20 December 2016 / Revised: 17 January 2017 / Accepted: 19 January 2017 / Published: 23 January 2017
(This article belongs to the Special Issue B Cells in Autoimmunity)
In the past two decades it has become clear that in addition to antigen presentation and antibody production B cells play prominent roles in immune regulation. While B cell-derived IL-10 has garnered much attention, B cells also effectively regulate inflammation by a variety of IL-10-independent mechanisms. B cell regulation has been studied in both autoimmune and inflammatory diseases. While collectively called regulatory B cells (Breg), no definitive phenotype has emerged for B cells with regulatory potential. This has made their study challenging and thus unique B cell regulatory mechanisms have emerged in a disease-dependent manner. Thus to harness the therapeutic potential of Breg, further studies are needed to understand how they emerge and are induced to evoke their regulatory activities. View Full-Text
Keywords: B cell; immune regulation; autoimmunity; inflammation B cell; immune regulation; autoimmunity; inflammation
MDPI and ACS Style

Ray, A.; Dittel, B.N. Mechanisms of Regulatory B cell Function in Autoimmune and Inflammatory Diseases beyond IL-10. J. Clin. Med. 2017, 6, 12.

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