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J. Clin. Med. 2017, 6(1), 7;

Stromal Modulators of TGF-β in Cancer

Metastasis Research Laboratory, GIGA-Cancer, University of Liege, 4000 Liege, Belgium
Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Université Montpellier, Institut Régional du Cancer de Montpellier, 34298 Montpellier, France
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Emanuel F. Petricoin
Received: 4 November 2016 / Revised: 19 December 2016 / Accepted: 23 December 2016 / Published: 6 January 2017
(This article belongs to the Special Issue Biological and Clinical Aspects of TGF-beta in Carcinogenesis)
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Transforming growth factor-β (TGF-β) is an intriguing cytokine exhibiting dual activities in malignant disease. It is an important mediator of cancer invasion, metastasis and angiogenesis, on the one hand, while it exhibits anti-tumor functions on the other hand. Elucidating the precise role of TGF-β in malignant development and progression requires a better understanding of the molecular mechanisms involved in its tumor suppressor to tumor promoter switch. One important aspect of TGF-β function is its interaction with proteins within the tumor microenvironment. Several stromal proteins have the natural ability to interact and modulate TGF-β function. Understanding the complex interplay between the TGF-β signaling network and these stromal proteins may provide greater insight into the development of novel therapeutic strategies that target the TGF-β axis. The present review highlights our present understanding of how stroma modulates TGF-β activity in human cancers. View Full-Text
Keywords: cancer-associated fibroblasts; proteases; proteoglycans; TGF-β; stroma cancer-associated fibroblasts; proteases; proteoglycans; TGF-β; stroma

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Costanza, B.; Umelo, I.A.; Bellier, J.; Castronovo, V.; Turtoi, A. Stromal Modulators of TGF-β in Cancer. J. Clin. Med. 2017, 6, 7.

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