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Journal of Clinical Medicine, Volume 11, Issue 3

2022 February-1 - 425 articles

Cover Story: Dry age-related macular degeneration (AMD) is a leading cause of irreversible blindness and is characterized by the death of key retinal cells and the propagation of an inflammatory retinal microenvironment. The atrophic form of the disease, for which there are no approved treatments, is characterized by loss of the retinal pigment epithelium (RPE) and the overlying photoreceptors and is associated with activation of the retinal innate immune cells, microglia. While the etiology of AMD is unknown, the Fas receptor has been shown to be a key regulator of death pathway activation and retinal inflammation. Treatment with a Fas inhibitor has the clinical potential to prevent cell death pathway and microglial activation, serving to protect the vision of patients with atrophic AMD. View this paper
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Articles (425)

  • Article
  • Open Access
53 Citations
7,321 Views
14 Pages

The Influence of Angle Alpha, Angle Kappa, and Optical Aberrations on Visual Outcomes after the Implantation of a High-Addition Trifocal IOL

  • Guadalupe Cervantes-Coste,
  • André Tapia,
  • Claudia Corredor-Ortega,
  • Mariana Osorio and ,
  • Rafael Valdez,
  • Martha Massaro,
  • Cecilio Velasco-Barona and
  • Roberto Gonzalez-Salinas
  • + 3 authors+ 0 author

8 February 2022

The aim of our investigation was to examine the possible correlations between optical aberrations, angle kappa, angle alpha, and visual outcomes following cataract surgery. In total, 56 eyes of 28 patients were implanted with the Liberty 677MY trifoc...

(This article belongs to the Special Issue Hot Topics in PRESBYOPIA 2021)
  • Article
  • Open Access
9 Citations
5,426 Views
14 Pages

Self-Reported Pain and Emotional Reactivity in Bipolar Disorder: A Prospective FACE-BD Study

  • Nathan Risch,
  • Jonathan Dubois,
  • Katia M’bailara,
  • Irena Cussac and ,
  • Bruno Etain,
  • Raoul Belzeaux,
  • Caroline Dubertret,
  • Emmanuel Haffen,
  • Raymund Schwan and
  • on behalf of the FondaMental Advanced Centers of Expertise in Bipolar Disorders (FACE-BD) Collaborators
  • + 11 authors+ 6 authors

8 February 2022

In patients with bipolar disorder (BD), pain prevalence is close to 30%. It is important to determine whether pain influences BD course and to identify factors associated with pain in BD in order to guide BD management. This naturalistic, prospective...

(This article belongs to the Special Issue The Clinical Management of Bipolar Disorders)
  • Article
  • Open Access
11 Citations
3,600 Views
16 Pages

A Systematic Literature Review of the Relationship between Serum Ferritin and Outcomes in Myelodysplastic Syndromes

  • Esther Natalie Oliva,
  • Krystal Huey,
  • Sohan Deshpande,
  • Monica Turner and ,
  • Madhura Chitnis,
  • Emma Schiller,
  • Derek Tang,
  • Aylin Yucel,
  • Christina Hughes and
  • Farrukh Shah
  • + 5 authors+ 0 author

8 February 2022

Anemia is the most common form of cytopenia in patients with myelodysplastic syndromes (MDS), who require chronic red blood cell transfusions and may present high serum ferritin (SF) levels as a result of iron overload. To better understand the poten...

(This article belongs to the Section Hematology)
  • Article
  • Open Access
22 Citations
5,928 Views
12 Pages

Guided Bone Regeneration in the Edentulous Atrophic Maxilla Using Deproteinized Bovine Bone Mineral (DBBM) Combined with Platelet-Rich Fibrin (PRF)—A Prospective Study

  • João Manuel Mendez Caramês,
  • Filipe Araújo Vieira,
  • Gonçalo Bártolo Caramês,
  • Ana Catarina Pinto and ,
  • Helena Cristina Oliveira Francisco and
  • Duarte Nuno da Silva Marques
  • + 1 author+ 0 author

8 February 2022

Background: Bone regeneration procedures represent a major challenge in oral surgery. This study aimed to evaluate a composite PRF/particulate xenograft in guided bone regeneration. Methods: Edentulous patients with horizontal ridge deficiencies in t...

(This article belongs to the Topic New Frontiers and Boundaries in the Use of Biomaterials in Dentistry)
  • Article
  • Open Access
3 Citations
4,417 Views
11 Pages

A New System for Periprosthetic Fracture Stabilization—A Biomechanical Comparison

  • Daniel Rau,
  • Gabriele Rußow,
  • Mark Heyland,
  • Dag Wulsten and ,
  • Clemens Kösters,
  • Werner Schmölz and
  • Sven Märdian
  • + 2 authors+ 0 author

8 February 2022

In recent years, an increase in periprosthetic femur fractures has become apparent due to the increased number of hip replacements. In the case of Vancouver type B1 fractures, locking plate systems offer safe procedures. This study compared the dista...

(This article belongs to the Special Issue Management of Periprosthetic Fractures: Current Experience and Future Developments)
  • Article
  • Open Access
12 Citations
3,889 Views
14 Pages

Kidney Function According to Different Equations in Patients Admitted to a Cardiology Unit and Impact on Outcome

  • Vincenzo Livio Malavasi,
  • Anna Chiara Valenti,
  • Sara Ruggerini,
  • Marcella Manicardi and ,
  • Carlotta Orlandi,
  • Daria Sgreccia,
  • Marco Vitolo,
  • Marco Proietti,
  • Gregory Y. H. Lip and
  • Giuseppe Boriani
  • + 5 authors+ 0 author

8 February 2022

Background: This paper aims to evaluate the concordance between the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula and alternative equations and to assess their predictive power for all-cause mortality in unselected patients disc...

(This article belongs to the Special Issue Clinical Care for Older Adults with Cardiovascular Disease: Current Challenges and Perspectives Ahead)
  • Article
  • Open Access
23 Citations
5,366 Views
14 Pages

Effects of Moderate Alcohol Consumption in Non-Alcoholic Fatty Liver Disease

  • Peter Lemmer,
  • Paul Manka,
  • Jan Best,
  • Alisan Kahraman and ,
  • Julia Kälsch,
  • Ramiro Vilchez-Vargas,
  • Alexander Link,
  • Hsin Chiang,
  • Guido Gerken and
  • Svenja Sydor
  • + 7 authors+ 2 authors

8 February 2022

Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) have emerged as leading causes of chronic liver diseases worldwide. ALD and NAFLD share several pathophysiological patterns as well as histological features, while clinically...

(This article belongs to the Collection Clinical Research in Hepatology)
  • Review
  • Open Access
99 Citations
14,165 Views
27 Pages

The Immune-Centric Revolution in the Diabetic Foot: Monocytes and Lymphocytes Role in Wound Healing and Tissue Regeneration—A Narrative Review

  • Laura Rehak,
  • Laura Giurato,
  • Marco Meloni,
  • Andrea Panunzi and ,
  • Giada Maria Manti and
  • Luigi Uccioli
  • + 1 author+ 0 author

8 February 2022

Monocytes and lymphocytes play a key role in physiologic wound healing and might be involved in the impaired mechanisms observed in diabetes. Skin wound macrophages are represented by tissue resident macrophages and infiltrating peripheral blood recr...

(This article belongs to the Special Issue Diabetic Foot Complications: Current Challenges and Future Prospects—Part II)
  • Article
  • Open Access
57 Citations
5,131 Views
11 Pages

The Ratio of Hemoglobin to Red Cell Distribution Width: A Strong Predictor of Clinical Outcome in Patients with Heart Failure

  • Eldad Rahamim,
  • Donna R. Zwas,
  • Andre Keren,
  • Gabby Elbaz-Greener and ,
  • Mahsati Ibrahimli,
  • Offer Amir and
  • Israel Gotsman
  • + 2 authors+ 0 author

8 February 2022

Background: Hemoglobin (Hb) is a standard and widely available clinical parameter that predicts clinical outcomes in heart failure (HF) patients. Red cell distribution width (RDW) is also a routinely measured clinical parameter that is predictive of...

(This article belongs to the Special Issue Cardiovascular Disease in 2021 and beyond—What Have We Learned and How Do We Move On?)
  • Article
  • Open Access
9 Citations
5,153 Views
9 Pages

Comparison of Medical and Surgical Treatment in Severe Bell’s Palsy

  • Yong Kim,
  • Seung Geun Yeo,
  • Hwa Sung Rim,
  • Jongha Lee and ,
  • Dokyoung Kim,
  • Sung Soo Kim,
  • Dong Choon Park,
  • Jae Yong Byun and
  • Sang Hoon Kim
  • + 4 authors+ 0 author

8 February 2022

(1) Background: The effectiveness of decompression surgery for Bell’s palsy is controversial. This study investigated the effects of facial nerve decompression in patients with severe Bell’s palsy who were expected to have a poor prognosi...

(This article belongs to the Special Issue Diagnosis and Management of Peripheral Nerve Injuries)
  • Article
  • Open Access
10 Citations
4,085 Views
9 Pages

Predictors for Prehospital First-Pass Intubation Success in Germany

  • Lukas Reinert,
  • Steffen Herdtle,
  • Christian Hohenstein,
  • Wilhelm Behringer and
  • Jasmin Arrich

8 February 2022

(1) Background: Endotracheal intubation in the prehospital setting is an important skill for emergency physicians, paramedics, and other members of the EMS providing airway management. Its success determines complications and patient mortality. The a...

(This article belongs to the Section Emergency Medicine)
  • Article
  • Open Access
4 Citations
3,316 Views
10 Pages

Forced Diuresis with Matched Isotonic Intravenous Hydration Prevents Renal Contrast Media Accumulation

  • Yael Ben-Haim,
  • Ehud Chorin,
  • Aviram Hochstadt,
  • Merav Ingbir and ,
  • Yaron Arbel,
  • Shafik Khoury,
  • Amir Halkin,
  • Ariel Finkelstein,
  • Shmuel Banai and
  • Maayan Konigstein
  • + 5 authors+ 0 author

8 February 2022

The accumulation of contrast media in the kidneys might lead to contrast-induced acute kidney injury. In this prospective, controlled observational study, we aimed to evaluate whether forced diuresis with matched isotonic intravenous hydration preven...

(This article belongs to the Special Issue New Insights into Cardio-Renal Interactions: Novel Definitions, Pathophysiology and Management)
  • Article
  • Open Access
27 Citations
4,284 Views
12 Pages

Characteristics and Outcomes of Bloodstream Infections in a Tertiary-Care Pediatric Hematology–Oncology Unit: A 10-Year Study

  • Davide Mattei,
  • Valentina Baretta,
  • Annarita Mazzariol,
  • Laura Maccacaro and ,
  • Rita Balter,
  • Ada Zaccaron,
  • Elisa Bonetti,
  • Matteo Chinello,
  • Virginia Vitale and
  • Simone Cesaro
  • + 10 authors+ 5 authors

8 February 2022

Bloodstream infections (BSIs) after chemotherapy or hematopoietic stem cell transplantation (HSCT) are a leading cause of morbidity and mortality. Data on 154 BSIs that occurred in 111 onco-hematological patients (57 hematological malignancies, 28 so...

(This article belongs to the Section Hematology)
  • Article
  • Open Access
11 Citations
3,611 Views
13 Pages

Results of the pToWin Study: Using the pCONUS Device for the Treatment of Wide-Neck Intracranial Aneurysms

  • Marta Aguilar Pérez,
  • Hans Henkes,
  • Wiebke Kurre,
  • Carlos Bleise and ,
  • Pedro Nicolás Lylyk,
  • Javier Lundquist,
  • Francis Turjman,
  • Hanan Alhazmi,
  • Christian Loehr and
  • Pedro Lylyk
  • + 11 authors+ 6 authors

8 February 2022

Coil embolization has become a well-established option for the treatment of intracranial aneurysms. Yet, wide-neck bifurcation aneurysms (WNBAs) remain a challenge. The pCONUS is the first generation of a stent-like implant for the bridging of WNBAs...

(This article belongs to the Special Issue Hemorrhagic Stroke)
  • Feature Paper
  • Review
  • Open Access
31 Citations
6,912 Views
16 Pages

Antimicrobial Meshes for Hernia Repair: Current Progress and Perspectives

  • Simona Mirel,
  • Alexandra Pusta,
  • Mihaela Moldovan and
  • Septimiu Moldovan

8 February 2022

Recent advances in the development of biomaterials have given rise to new options for surgery. New-generation medical devices can control chemical breakdown and resorption, prevent post-operative adhesion, and stimulate tissue regeneration. For the f...

(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
  • Correction
  • Open Access
1 Citations
1,778 Views
1 Page

Correction: Ratka et al. The Effect of In Vitro Electrolytic Cleaning on Biofilm-Contaminated Implant Surfaces. J. Clin. Med. 2019, 8, 1397

  • Christoph Ratka,
  • Paul Weigl,
  • Dirk Henrich,
  • Felix Koch and ,
  • Markus Schlee and
  • Holger Zipprich
  • + 1 author+ 0 author

8 February 2022

There was an error in the original article [...]

(This article belongs to the Special Issue Osseointegrated Oral implants: Mechanisms of Implant Anchorage, Threats and Long-Term Survival Rates)
  • Article
  • Open Access
5 Citations
3,060 Views
15 Pages

Development and Validation of the Acute PNeumonia Early Assessment Score for Safely Discharging Low-Risk SARS-CoV-2-Infected Patients from the Emergency Department

  • Sergio Venturini,
  • Elisa Pontoni,
  • Rossella Carnelos,
  • Domenico Arcidiacono and ,
  • Silvia Da Ros,
  • Laura De Santi,
  • Daniele Orso,
  • Francesco Cugini,
  • Sara Fossati and
  • GianLuca Colussi
  • + 10 authors+ 5 authors

8 February 2022

A continuous demand for assistance and an overcrowded emergency department (ED) require early and safe discharge of low-risk severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients. We developed (n = 128) and validated (n = 330...

(This article belongs to the Special Issue Clinical Health Care during the COVID-19 Pandemic: Therapeutic and Management Strategies)
  • Editorial
  • Open Access
2,232 Views
2 Pages

8 February 2022

Epidemiology is the study of the distribution and determinants of health-related states or events in specified populations, and the application of this study to the control of health problems [...]

(This article belongs to the Section Epidemiology & Public Health)
  • Article
  • Open Access
8 Citations
4,895 Views
16 Pages

Influence of Body Mass Index, Cancer Type and Treatment on Long-Term Metabolic and Liver Outcomes in Childhood Cancer Survivors

  • Agostino Milluzzo,
  • Lucia Manuella,
  • Emanuela Cannata,
  • Giovanna Russo and ,
  • Sandro La Vignera,
  • Francesco Purrello,
  • Andrea Di Cataldo and
  • Laura Sciacca
  • + 3 authors+ 0 author

7 February 2022

In the last decade, the survival of subjects affected by cancer in childhood has significantly improved. The increased lifespan of childhood cancer survivors (CCS) led to a greater risk for long-term, therapy-related morbidity. To identify the clinic...

(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
  • Article
  • Open Access
10 Citations
2,863 Views
11 Pages

Incidence of SARS-CoV-2 Infection and Related Mortality by Education Level during Three Phases of the 2020 Pandemic: A Population-Based Cohort Study in Rome

  • Laura Angelici,
  • Chiara Sorge,
  • Mirko Di Martino,
  • Giovanna Cappai and ,
  • Massimo Stafoggia,
  • Nera Agabiti,
  • Enrico Girardi,
  • Simone Lanini,
  • Emanuele Nicastri and
  • Giulia Cesaroni
  • + 6 authors+ 1 author

7 February 2022

Evidence on social determinants of health on the risk of SARS-CoV-2 infection and adverse outcomes is still limited. Therefore, this work investigates educational disparities in the incidence of infection and mortality within 30 days of the onset of...

(This article belongs to the Special Issue COVID-19: Special Populations and Risk Factors)
  • Communication
  • Open Access
12 Citations
7,387 Views
8 Pages

Safety Measures for Maintaining Low Endophthalmitis Rate after Intravitreal Anti-Vascular Endothelial Growth Factor Injection before and during the COVID-19 Pandemic

  • Koji Tanaka,
  • Hiroyuki Shimada,
  • Ryusaburo Mori,
  • Yorihisa Kitagawa and ,
  • Hajime Onoe,
  • Kazuki Tamura and
  • Hiroyuki Nakashizuka
  • + 2 authors+ 0 author

7 February 2022

During the COVID-19 pandemic, intravitreal injections are performed with patients wearing masks. The risk of endophthalmitis after intravitreal injection is reported to increase due to an influx of exhaled air containing oral bacteria from the upper...

(This article belongs to the Section Ophthalmology)
  • Article
  • Open Access
4 Citations
6,490 Views
9 Pages

7 February 2022

Cochlear synaptopathy refers to a subclinical hearing pathology which could potentially explain hearing difficulties within the normal hearing threshold; it is also called “hidden hearing loss”. We hypothesized that a temporary threshold...

(This article belongs to the Section Otolaryngology)
  • Editorial
  • Open Access
2,850 Views
2 Pages

Advances in Neuromodulation for Chronic Pain

  • Maarten Moens and
  • Lisa Goudman

7 February 2022

In the past decade, neuromodulation as a treatment option for pain took a huge interest in innovating and developing more effective paradigms to conquer chronic pain syndromes [...]

(This article belongs to the Special Issue Advances in Neuromodulation for Pain Management)
  • Article
  • Open Access
5 Citations
4,150 Views
29 Pages

Usefulness of the C2HEST Score in Predicting the Clinical Outcomes of COVID-19 in Diabetic and Non-Diabetic Cohorts

  • Damian Gajecki,
  • Adrian Doroszko,
  • Małgorzata Trocha,
  • Katarzyna Giniewicz and ,
  • Krzysztof Kujawa,
  • Marek Skarupski,
  • Jakub Gawryś,
  • Tomasz Matys,
  • Ewa Szahidewicz-Krupska and
  • Katarzyna Madziarska
  • + 25 authors+ 20 authors

7 February 2022

Background: Diabetes mellitus is among the most frequent comorbidities worsening COVID-19 outcome. Nevertheless, there are no data regarding the optimal risk stratification of patients with diabetes and COVID-19. Since individual C2HEST components re...

(This article belongs to the Special Issue COVID-19: Special Populations and Risk Factors)
  • Review
  • Open Access
26 Citations
7,054 Views
15 Pages

Multimodality Imaging in Cardiomyopathies with Hypertrophic Phenotypes

  • Emanuele Monda,
  • Giuseppe Palmiero,
  • Michele Lioncino,
  • Marta Rubino and ,
  • Annapaola Cirillo,
  • Adelaide Fusco,
  • Martina Caiazza,
  • Federica Verrillo,
  • Gaetano Diana and
  • Giuseppe Limongelli
  • + 13 authors+ 8 authors

7 February 2022

Multimodality imaging is a comprehensive strategy to investigate left ventricular hypertrophy (LVH), providing morphologic, functional, and often clinical information to clinicians. Hypertrophic cardiomyopathy (HCM) is defined by an increased LV wall...

(This article belongs to the Section Cardiology)
  • Review
  • Open Access
8 Citations
5,609 Views
16 Pages

Evolution and New Horizons of Endoscopy in Inflammatory Bowel Diseases

  • Tommaso Lorenzo Parigi,
  • Elisabetta Mastrorocco,
  • Leonardo Da Rio,
  • Mariangela Allocca and ,
  • Ferdinando D’Amico,
  • Alessandra Zilli,
  • Gionata Fiorino,
  • Silvio Danese and
  • Federica Furfaro
  • + 4 authors+ 0 author

7 February 2022

Endoscopy is the mainstay of inflammatory bowel disease (IBD) evaluation and the pillar of colorectal cancer surveillance. Endoscopic equipment, both hardware and software, are advancing at an incredible pace. Virtual chromoendoscopy is now widely av...

(This article belongs to the Special Issue Evolution and New Horizons of Endoscopy in Inflammatory Bowel Diseases)
  • Article
  • Open Access
24 Citations
3,760 Views
11 Pages

Colitis-Associated Colorectal Cancer in Patients with Inflammatory Bowel Diseases in a Tertiary Referral Center: A Propensity Score Matching Analysis

  • Kasper Maryńczak,
  • Jakub Włodarczyk,
  • Zofia Sabatowska,
  • Adam Dziki and ,
  • Łukasz Dziki and
  • Marcin Włodarczyk
  • + 1 author+ 0 author

7 February 2022

Background: Inflammatory bowel disease (IBD) is a risk factor in developing colitis-associated colorectal cancer (CA-CRC). CA-CRC causes the death of about 15% IBD patients and the risk is 1.5–2.4 fold higher among IBD sufferers than in the gen...

(This article belongs to the Special Issue Advances in Inflammatory Bowel Disease)
  • Article
  • Open Access
12 Citations
4,876 Views
13 Pages

The Relation between Negative Automatic Thoughts and Psychological Inflexibility in Schizophrenia

  • Cosmin O. Popa,
  • Adrian V. Rus,
  • Wesley C. Lee,
  • Cristiana Cojocaru and ,
  • Alina Schenk,
  • Vitalie Văcăraș,
  • Peter Olah,
  • Simona Mureșan,
  • Simona Szasz and
  • Cristina Bredicean
  • + 5 authors+ 0 author

7 February 2022

Background: Schizophrenia is one of the most severe disorders in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) spectrum. Negative automatic thoughts (NAT), cognitive fusion (CF), and experiential avoidance (EA), as part of psychol...

(This article belongs to the Special Issue Cognitive Behavioral Therapy: Clinical Aspects and New Approaches)
  • Article
  • Open Access
13 Citations
3,874 Views
9 Pages

Factors Associated with Hepatitis B Medication Adherence and Persistence among Underserved Chinese and Vietnamese Americans

  • Aisha Bhimla,
  • Lin Zhu,
  • Wenyue Lu,
  • Sarit Golub and ,
  • Chibuzo Enemchukwu,
  • Elizabeth Handorf,
  • Yin Tan,
  • Ming-Chin Yeh,
  • Minhhuyen T. Nguyen and
  • Grace X. Ma
  • + 6 authors+ 1 author

7 February 2022

Background: Hepatitis B virus (HBV) infection disproportionately affects Asian Americans in the United States, while this population faces low adherence to HBV treatment. Using the information–motivation–behavioral skills model (IMB), the...

(This article belongs to the Topic Infectious Diseases)
  • Article
  • Open Access
10 Citations
2,682 Views
4 Pages

MRI-Linac Economics II: Rationalizing Schedules

  • Peter A. S. Johnstone,
  • John Kerstiens,
  • Stuart Wasserman and
  • Stephen A. Rosenberg

7 February 2022

Objective: Two benefits of MR-guided radiotherapy (MRgRT) are the ability to track target structures while treatment is being delivered and the ability to adapt plans daily for some lesions based on changing anatomy. These unique capacities come at t...

(This article belongs to the Collection Advances of MRI in Radiation Oncology)
  • Article
  • Open Access
7 Citations
3,571 Views
10 Pages

Additional Lymphaticovenular Anastomosis on the Posterior Side for Treatment of Primary Lower Extremity Lymphedema

  • Akitatsu Hayashi,
  • Giuseppe Visconti,
  • Chia-Shen (Johnson) Yang,
  • Nobuko Hayashi and
  • Hidehiko Yoshimatsu

7 February 2022

The efficacy of lymphaticovenular anastomosis (LVA) for the treatment of primary lymphedema has been reported. Previous research suggested the efficacy of LVA on the anterior side of the lower limb, but no research has yet underlined the effectivenes...

(This article belongs to the Special Issue Surgical Management of Lymphedema: Past, Present, and Future)
  • Review
  • Open Access
10 Citations
3,235 Views
8 Pages

The Potential Cardiotoxicity of Immune Checkpoint Inhibitors

  • Inbar Nardi Agmon,
  • Osnat Itzhaki Ben Zadok and
  • Ran Kornowski

7 February 2022

The use of immune checkpoint inhibitors (ICIs) as a mono- or adjuvant oncologic treatment is rapidly expanding to most fields of cancer. Alongside their efficacy, ICIs carry the risk of immune-related adverse events (irAEs) arising from misguided imm...

(This article belongs to the Special Issue Cardio-Oncology: Diagnosis and Management of Cardiovascular Disease in Cancer Patients)
  • Article
  • Open Access
8 Citations
4,698 Views
11 Pages

7 February 2022

Numerous formulas that can predict endotracheal intubation depth at the corner of the mouth or the nasal wing of patients have been reported, even though the oral and nasal cavity anatomies differ among patients. Therefore, the purpose of this study...

(This article belongs to the Section Cardiology)
  • Brief Report
  • Open Access
11 Citations
3,384 Views
5 Pages

7 February 2022

Background: Patient knowledge is crucial for managing and/or monitoring patients with heart failure (HF). However, “real-life” evidence of knowledge level and awareness in HF is yet to be explored. We assessed unselected HF patients&rsquo...

(This article belongs to the Special Issue Cardiovascular Disease: Risk Factors, Comorbidities, and Prevention)
  • Article
  • Open Access
3 Citations
2,356 Views
10 Pages

In Patients with Obesity, Are Affective Temperaments Associated with Attrition? An Evaluation during and before the SARS-CoV-2 Pandemic

  • Enrica Marzola,
  • Giovanni Abbate-Daga,
  • Elena Scumaci,
  • Valentina Ponzo and ,
  • Ilaria Goitre,
  • Marianna Pellegrini,
  • Chiara D’Eusebio,
  • Andrea Benso,
  • Sara Belcastro and
  • Simona Bo
  • + 9 authors+ 4 authors

7 February 2022

Timely data on attrition from weight loss programs for patients with obesity during the SARS-CoV-2 pandemic are lacking, so we aimed to contribute to filling this gap in the literature by comparing attrition during or outside of the SARS-CoV-2 pandem...

(This article belongs to the Section Mental Health)
  • Review
  • Open Access
3 Citations
5,466 Views
12 Pages

Electronic Patient-Reported Outcomes in Nephrology: Focus on Hemodialysis

  • Rosa Pérez-Morales,
  • Juan Manuel Buades-Fuster,
  • Vicent Esteve-Simó,
  • Manuel Macía-Heras and ,
  • Carmen Mora-Fernández and
  • Juan F. Navarro-González
  • + 1 author+ 0 author

7 February 2022

The success of hemodialysis (HD) treatments has been evaluated using objective measures of analytical parameters, or machine-measured parameters, despite having available validated instruments that assess patient perspective. There is an emerging int...

(This article belongs to the Collection Clinical Research and Advances in Hemodialysis)
  • Review
  • Open Access
101 Citations
15,717 Views
22 Pages

Viscoelastic Hemostatic Assays: A Primer on Legacy and New Generation Devices

  • Oksana Volod,
  • Connor M. Bunch,
  • Nuha Zackariya,
  • Ernest E. Moore and ,
  • Hunter B. Moore,
  • Hau C. Kwaan,
  • Matthew D. Neal,
  • Mahmoud D. Al-Fadhl,
  • Shivani S. Patel and
  • Mark M. Walsh
  • + 15 authors+ 10 authors

7 February 2022

Viscoelastic hemostatic assay (VHAs) are whole blood point-of-care tests that have become an essential method for assaying hemostatic competence in liver transplantation, cardiac surgery, and most recently, trauma surgery involving hemorrhagic shock....

(This article belongs to the Special Issue Clinical Research on Viscoelastic Testing)
  • Article
  • Open Access
28 Citations
5,400 Views
11 Pages

Women in Advanced Reproductive Age: Are the Follicular Output Rate, the Follicle-Oocyte Index and the Ovarian Sensitivity Index Predictors of Live Birth in an IVF Cycle?

  • Andrea Roberto Carosso,
  • Rik van Eekelen,
  • Alberto Revelli,
  • Stefano Canosa and ,
  • Noemi Mercaldo,
  • Chiara Benedetto and
  • Gianluca Gennarelli
  • + 2 authors+ 0 author

6 February 2022

(1) Background: Several researchers have investigated alternative markers related to ovarian responsiveness in order to better predict IVF outcomes, particularly in advanced reproductive-aged women. The follicular output rate (FORT), the follicle-ooc...

(This article belongs to the Section Obstetrics & Gynecology)
  • Article
  • Open Access
5 Citations
4,428 Views
11 Pages

Single and Multiple Dose PK–PD Characterization for Carisoprodol. Part I: Pharmacokinetics, Metabolites, and 2C19 Phenotype Influence. Double-Blind, Placebo-Controlled Clinical Trial in Healthy Volunteers

  • Aitana Calvo,
  • Saioa Alonso,
  • Esther Prieto,
  • Ana Ascaso-del-Rio and ,
  • Jordi Ortuño,
  • Nieves Fernandez and
  • Antonio Portolés
  • + 2 authors+ 0 author

6 February 2022

Carisoprodol was authorised in 1959 without a full pharmacokinetic–pharmacodynamic (PK–PD) characterisation. We designed a crossover, double-blind, placebo-controlled, randomized clinical trial to characterize the PKs of carisoprodol and...

(This article belongs to the Collection Practice and Research in Clinical Pharmacology)
  • Review
  • Open Access
38 Citations
8,579 Views
16 Pages

Do the Current Guidelines for Heart Failure Diagnosis and Treatment Fit with Clinical Complexity?

  • Paolo Severino,
  • Andrea D’Amato,
  • Silvia Prosperi,
  • Alessandra Dei Cas and ,
  • Anna Vittoria Mattioli,
  • Antonio Cevese,
  • Giuseppina Novo,
  • Maria Prat,
  • Roberto Pedrinelli and
  • on behalf of the Italian National Institute for Cardiovascular Research (INRC)
  • + 12 authors+ 7 authors

6 February 2022

Heart failure (HF) is a clinical syndrome defined by specific symptoms and signs due to structural and/or functional heart abnormalities, which lead to inadequate cardiac output and/or increased intraventricular filling pressure. Importantly, HF beco...

(This article belongs to the Special Issue Advances and Perspectives in Heart Failure)
  • Article
  • Open Access
19 Citations
4,453 Views
17 Pages

Benefits of Telemonitoring of Pulmonary Function—3-Month Follow-Up of Home Electronic Spirometry in Patients with Duchenne Muscular Dystrophy

  • Eliza Wasilewska,
  • Agnieszka Sobierajska-Rek,
  • Sylwia Małgorzewicz,
  • Mateusz Soliński and
  • Ewa Jassem

6 February 2022

Background: In patients with Duchenne Muscular Dystrophy (DMD), the respiratory system determines the quality and length of life; therefore, the search for easy and safe everyday monitoring of the pulmonary function is currently extremely important,...

(This article belongs to the Section Epidemiology & Public Health)
  • Article
  • Open Access
7 Citations
3,464 Views
8 Pages

The Effect of the COVID-19 Pandemic on Patient Selection, Surgical Procedures, and Postoperative Complications in a Specialized Dental Implant Clinic

  • Balazs Feher,
  • Cordelia Wieser,
  • Theresa Lukes,
  • Christian Ulm and ,
  • Reinhard Gruber and
  • Ulrike Kuchler
  • + 1 author+ 0 author

6 February 2022

During the coronavirus disease 2019 (COVID-19) pandemic, aerosol-generating procedures, including dental implant treatments, are considered high-risk. With dental implant treatment mostly an elective procedure, we aimed to assess whether the pandemic...

(This article belongs to the Collection Impact of COVID-19 on the Dental Community)
  • Article
  • Open Access
17 Citations
4,915 Views
16 Pages

Effects of the Dental Caries Preventive Procedure on the White Spot Lesions during Orthodontic Treatment—An Open Label Randomized Controlled Trial

  • Yudai Shimpo,
  • Yoshiaki Nomura,
  • Toshiko Sekiya,
  • Chihiro Arai and ,
  • Ayako Okada,
  • Kaoru Sogabe,
  • Nobuhiro Hanada and
  • Hiroshi Tomonari
  • + 3 authors+ 0 author

6 February 2022

(1) Background: The aim of this study was to assess the preventive effect of tooth surface disinfection treatment, in addition to fluoride application, during fixed orthodontic treatment. (2) Methods: An open label randomized control trial for the ev...

(This article belongs to the Special Issue Recent Advances in the Management of Dental Caries)
  • Article
  • Open Access
1 Citations
3,703 Views
9 Pages

Diagnostic Interval in Extranodal Non-Hodgkin Head and Neck Lymphomas

  • Alba Bello Castro,
  • Juan Seoane,
  • Máximo Francisco Fraga Rodríguez,
  • Francisco Gude Sampedro and ,
  • Javier Seoane Romero,
  • Benjamín Martin-Biedma and
  • Pablo Castelo-Baz
  • + 2 authors+ 0 author

6 February 2022

The aim of this study is to measure the diagnostic interval (DI) of primary extranodal non-Hodgkin lymphomas (PE-NHL) affecting the head and neck and to discover any associated factors. With this aim, we performed a retrospective observational study...

(This article belongs to the Section Otolaryngology)
  • Article
  • Open Access
20 Citations
6,081 Views
12 Pages

6 February 2022

Digital smile design (DSD) technology, which takes pictures of patients’ faces together with anterior dentition and uses them for prosthesis design, has been recently introduced. However, the limitation of DSD is that it evaluates a patient wit...

(This article belongs to the Collection Digital Dentistry: Advances and Challenges)
  • Article
  • Open Access
7 Citations
4,255 Views
13 Pages

Cyclin D1 Binding Protein 1 Responds to DNA Damage through the ATM–CHK2 Pathway

  • Yusuke Niwa,
  • Kenya Kamimura,
  • Kohei Ogawa,
  • Chiyumi Oda and ,
  • Yuto Tanaka,
  • Ryoko Horigome,
  • Masato Ohtsuka,
  • Hiromi Miura,
  • Koichi Fujisawa and
  • Shuji Terai
  • + 18 authors+ 13 authors

6 February 2022

Cyclin D1 binding protein 1 (CCNDBP1) is considered a tumor suppressor, and when expressed in tumor cells, CCNDBP1 can contribute to the viability of cancer cells by rescuing these cells from chemotherapy-induced DNA damage. Therefore, this study foc...

(This article belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
  • Article
  • Open Access
7 Citations
3,568 Views
10 Pages

Syndromic and Non-Syndromic Patients with Repaired Tetralogy of Fallot: Does It Affect the Long-Term Outcome?

  • Giulio Calcagni,
  • Camilla Calvieri,
  • Anwar Baban,
  • Francesco Bianco and ,
  • Rosaria Barracano,
  • Massimo Caputo,
  • Andrea Madrigali,
  • Stefani Silva Kikina,
  • Marco Alfonso Perrone and
  • Benedetta Leonardi
  • + 13 authors+ 8 authors

6 February 2022

Background: The impact of genetic syndromes on cardiac magnetic resonance imaging (cMRI) parameters, particularly on right and/or left ventricular dysfunction, associated with clinical parameters following the repair of Tetralogy of Fallot (rToF) is...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
7 Citations
3,219 Views
9 Pages

Differential Expression of miRNA-223 in Coronary In-Stent Restenosis

  • Shiva Ganjali,
  • Seyed Hamid Aghaee-Bakhtiari,
  • Željko Reiner and
  • Amirhossein Sahebkar

6 February 2022

Objective: In-stent restenosis (ISR) is an unfavorable complication that occurs in patients after coronary stenting. Despite the progress with advent of modern DES and new antiplatelet agents, restenosis still hampers PCI short- and long-term results...

(This article belongs to the Special Issue Current Advances in Acute Coronary Syndrome)
  • Article
  • Open Access
23 Citations
4,476 Views
14 Pages

Sex-Specific Aspects of Skeletal Muscle Metabolism in the Clinical Context of Intensive Care Unit-Acquired Weakness

  • Lilian Jo Engelhardt,
  • Julius J. Grunow,
  • Tobias Wollersheim,
  • Niklas M. Carbon and ,
  • Felix Balzer,
  • Joachim Spranger and
  • Steffen Weber-Carstens
  • + 2 authors+ 0 author

5 February 2022

(1) Background: Female sex is considered a risk factor for Intensive Care Unit-Acquired Weakness (ICUAW). The aim is to investigate sex-specific aspects of skeletal muscle metabolism in the context of ICUAW. (2) Methods: This is a sex-specific sub-an...

(This article belongs to the Special Issue Enhancing Recovery after Intensive Care Medicine in Clinical Practice)
  • Article
  • Open Access
15 Citations
5,144 Views
7 Pages

The Role of Topical Povidone-Iodine in the Management of Infectious Keratitis: A Pilot Study

  • Emilio Pedrotti,
  • Erika Bonacci,
  • Raphael Kilian,
  • Camilla Pagnacco and ,
  • Adriano Fasolo,
  • Marco Anastasi,
  • Gessica Manzini,
  • Francesca Bosello and
  • Giorgio Marchini
  • + 4 authors+ 0 author

5 February 2022

The aim of this prospective explorative study was to evaluate the safety and the effectiveness of topical polyvinylpyrrolidone-iodine (PVP-I) administered during the time-to-results period for pathogen identification and susceptibility testing in pat...

(This article belongs to the Special Issue Ocular Infection: Microbiological and Clinical Aspects)

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J. Clin. Med. - ISSN 2077-0383