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The Clinical Management of Bipolar Disorders
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The Clinical Management of Bipolar Disorders

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Mental Health".

Deadline for manuscript submissions: closed (21 April 2023) | Viewed by 10849

Special Issue Editors

Dr. Paul Roux

E-Mail Website
Guest Editor
1. DisAP-DevPsy, CESP, UMR 1018, INSERM, Université Paris Saclay, Université Versailles Saint Quentin, 94807 Villejuif, France
2. Centre Hospitalier Versailles, Service Hospitalo-Universitaire de Psychiatrie de l’Adulte et d’Addictologie, 177 Rue de Versailles, CEDEX, 78157 Le Chesnay, France
Interests: bipolar disorder; schizophrenia; neurocognition; metacognition; social cognition; psychosocial functioning; psychiatric disability; rehabilitation
Dr. Eric Brunet-Gouet

E-Mail Website
Guest Editor
1. DisAP-DevPsy, CESP, UMR 1018, INSERM, Université Paris Saclay, Université Versailles Saint Quentin, 94807 Villejuif, France
2. Centre Hospitalier Versailles, Service Hospitalo-Universitaire de Psychiatrie de l’Adulte et d’Addictologie, 177 Rue de Versailles, CEDEX, 78157 Le Chesnay, France
Interests: schizophrenia; social cognition; neuroimaging; event related potentials; IRMf

Special Issue Information

Dear Colleagues,

We are pleased to invite you to submit your original research work for inclusion in this Special Issue of the Journal of Clinical Medicine, titled “Clinical Management of Bipolar Disorders”. 

Bipolar disorders (BD) are complex and chronic affective disturbances characterized by multiple affective relapses and lasting functional and cognitive deficits during all phases, including remission. BD are linked to premature mortality from both suicide and medical comorbidities.

This Special Issue seeks to identify validated strategies for the clinical management of bipolar disorders, targeting not only clinical remission but also functional recovery. This may include:
1) New tools that help to predict relapses (smartphone applications, actimetry, etc.);
2) Pharmacological or psychological interventions improving clinical response during the acute phase of the disorder (either in a manic, depressive, or mixed episode) and prevent relapses;
3) Strategies for the detection and management of cognitive impairments, with innovative cognitive remediation procedures and procognitive medications; 
4) Longitudinal studies to establish the different trajectories of cognitive functions;
5) Strategies to reduce the harm of comorbidities, such as metabolic syndrome, sleep disturbances, attention-deficit hyperactivity disorder, substance-use disorders, etc.;
6) Interventions that improve patient adherence to long-term treatment;
7) Rehabilitation that alleviates the psychosocial burden for the patient, the family, and the caregivers, with a particular emphasis on recovery;
8) Strategies for the detection and management of the adverse consequences of childhood traumas;
9) Improving the prevention of suicide.

Dr. Paul Roux
Dr. Eric Brunet-Gouet
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bipolar disorders
  • relapse
  • cognition
  • metabolic syndrome
  • sleep
  • substance-use disorders
  • medication adherence
  • rehabilitation
  • childhood trauma
  • suicide

Published Papers (5 papers)

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Research

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9 pages, 257 KiB  
Article
Bipolar Disorder and Bone Mineral Density Z-Scores in Relation to Clinical Characteristics and Lithium Medication
by Anders Lassas, Karl-fredrik Norrback, Rolf Adolfsson and Martin Maripuu
J. Clin. Med. 2022, 11(23), 7158; https://doi.org/10.3390/jcm11237158 - 01 Dec 2022
Cited by 3 | Viewed by 1340
Abstract
Bipolar disorder is associated with a long range of medical comorbidities, including migraine, diabetes, and cardiovascular disease. Bipolar disorder has also been associated with an increased risk of bone fractures. Osteoporosis is a reduction in bone mineral density, which leads to an increased [...] Read more.
Bipolar disorder is associated with a long range of medical comorbidities, including migraine, diabetes, and cardiovascular disease. Bipolar disorder has also been associated with an increased risk of bone fractures. Osteoporosis is a reduction in bone mineral density, which leads to an increased risk for fragility fractures. Currently there is limited research on the association between bipolar disorder and osteoporosis. We aimed to study the association between high and low bone mineral density in relation to disease and treatment history in a sample of bipolar patients. We found that bipolar patients with high bone mineral density were more often on lithium medication, had a more active lifestyle and expressed lower current disease burden. Low mineral density was not associated with any of the addressed aspects of disease and treatment history. In conclusion our results support that patients on lithium treatment have higher bone mineral density; further studies are needed to address if lithium medication causes an increase in bone mineral density, and lowers the risk of bone fractures in bipolar disorder. Full article
(This article belongs to the Special Issue The Clinical Management of Bipolar Disorders)
13 pages, 795 KiB  
Article
Which Actigraphy Dimensions Predict Longitudinal Outcomes in Bipolar Disorders?
by Lisa Ferrand, Vincent Hennion, Ophelia Godin, Frank Bellivier, Jan Scott and Bruno Etain
J. Clin. Med. 2022, 11(8), 2204; https://doi.org/10.3390/jcm11082204 - 14 Apr 2022
Cited by 2 | Viewed by 1529
Abstract
Bipolar disorder (BD) is characterized by recurrent mood episodes. It is increasingly suggested that disturbances in sleep–wake cycles and/or circadian rhythms could represent valuable predictors of recurrence, but few studies have addressed this question. Euthymic individuals with BD (n = 69) undertook 3 [...] Read more.
Bipolar disorder (BD) is characterized by recurrent mood episodes. It is increasingly suggested that disturbances in sleep–wake cycles and/or circadian rhythms could represent valuable predictors of recurrence, but few studies have addressed this question. Euthymic individuals with BD (n = 69) undertook 3 weeks of actigraphy recording and were then followed up for a median duration of 3.5 years. Principal component analyses were used to identify core dimensions of sleep quantity/variability and circadian rhythmicity. Associations between clinical variables and actigraphy dimensions and time to first recurrence were explored using survival analyses, and then using area under the curve (AUC) analyses (early vs. late recurrence). Most participants (64%) experienced a recurrence during follow-up (median survival time: 18 months). After adjusting for potential confounding factors, an actigraphy dimension comprising amplitude and variability/stability of circadian rhythms was a significant predictor of time to recurrence (p = 0.009). The AUC for correct classification of early vs. late recurrence subgroups was only 0.64 for clinical predictors, but combining these variables with objectively measured intra-day variability improved the AUC to 0.82 (p = 0.04). Actigraphy estimates of circadian rhythms, particularly variability/stability and amplitude, may represent valid predictive markers of future BD recurrences and could be putative targets for future psychosocial interventions. Full article
(This article belongs to the Special Issue The Clinical Management of Bipolar Disorders)
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14 pages, 1954 KiB  
Article
Self-Reported Pain and Emotional Reactivity in Bipolar Disorder: A Prospective FACE-BD Study
by Nathan Risch, Jonathan Dubois, Katia M’bailara, Irena Cussac, Bruno Etain, Raoul Belzeaux, Caroline Dubertret, Emmanuel Haffen, Raymund Schwan, Ludovic Samalin, Paul Roux, Mircea Polosan, Marion Leboyer, Philippe Courtet, Emilie Olié and on behalf of the FondaMental Advanced Centers of Expertise in Bipolar Disorders (FACE-BD) Collaborators
J. Clin. Med. 2022, 11(3), 893; https://doi.org/10.3390/jcm11030893 - 08 Feb 2022
Cited by 2 | Viewed by 2920
Abstract
In patients with bipolar disorder (BD), pain prevalence is close to 30%. It is important to determine whether pain influences BD course and to identify factors associated with pain in BD in order to guide BD management. This naturalistic, prospective study used data [...] Read more.
In patients with bipolar disorder (BD), pain prevalence is close to 30%. It is important to determine whether pain influences BD course and to identify factors associated with pain in BD in order to guide BD management. This naturalistic, prospective study used data on 880 patients with BD from the French FACE-BD cohort who were divided into two groups according to the presence or absence of pain. Multivariate models were used to test whether pain was associated with affective states and personality traits while controlling for confounders. Then, multivariate models were used to test whether pain at baseline predicted global life functioning and depressive symptomatology at one year. At baseline, 22% of patients self-reported pain. The pain was associated with depressive symptomatology, levels of emotional reactivity in a quadratic relationship, and a composite variable of personality traits (affective lability, affective intensity, hostility/anger, and impulsivity). At one year, the pain was predictive of depression and lower global life functioning. Pain worsens mental health and well-being in patients with BD. The role of emotions, depression, and personality traits in pain has to be elucidated to better understand the high prevalence of pain in BD and to promote specific therapeutic strategies for patients experiencing pain. Full article
(This article belongs to the Special Issue The Clinical Management of Bipolar Disorders)
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Review

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11 pages, 899 KiB  
Review
Postpartum Relapse in Patients with Bipolar Disorder
by Javier Conejo-Galindo, Alejandro Sanz-Giancola, Miguel Ángel Álvarez-Mon, Miguel Á. Ortega, Luis Gutiérrez-Rojas and Guillermo Lahera
J. Clin. Med. 2022, 11(14), 3979; https://doi.org/10.3390/jcm11143979 - 08 Jul 2022
Cited by 4 | Viewed by 2042
Abstract
Pregnancy and postpartum are vital times of greater vulnerability to suffer a decompensation of bipolar disorder (BD). Methods: A systematic literature search was performed on public electronic medical databases, following PRISMA guidelines. Studies were included if they reported postpartum relapse in patients diagnosed [...] Read more.
Pregnancy and postpartum are vital times of greater vulnerability to suffer a decompensation of bipolar disorder (BD). Methods: A systematic literature search was performed on public electronic medical databases, following PRISMA guidelines. Studies were included if they reported postpartum relapse in patients diagnosed with BD according to Diagnosis Statistical Manual (DSM) or International Classification Disease (ICD) criteria. Results: Sixteen articles describing 6064 deliveries of 3977 women were included in the quantitative analyses. The overall risk of postpartum relapse was 36.77%. The methodology of the studies, the diagnostic criteria, the discrimination between BD type I and II, and the origin of the sample were very heterogeneous. Conclusions: the rate of postpartum bipolar relapse is very high, as it is considered to be a critical period. It is especially important to detect decompensation in this period and to evaluate mood-stabilizing treatment, given the high risk of relapse concentrated in a short period. Full article
(This article belongs to the Special Issue The Clinical Management of Bipolar Disorders)
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21 pages, 1118 KiB  
Review
Improving the Assessment Process of Family Functioning in Adult Bipolar Disorders: A PRISMA Systematic Review
by Caroline Munuera, Philippe Compagnone, Mathilde M. Husky, Paul Lebourleux, Fanny Petit and Katia M’bailara
J. Clin. Med. 2022, 11(3), 841; https://doi.org/10.3390/jcm11030841 - 05 Feb 2022
Cited by 1 | Viewed by 2007
Abstract
In order to determine family functioning in the treatment of adults with bipolar disorders, guidelines are needed regarding the way family functioning may be assessed. The present systematic review aims to investigate how family functioning is assessed in this context. Following PRISMA guidelines, [...] Read more.
In order to determine family functioning in the treatment of adults with bipolar disorders, guidelines are needed regarding the way family functioning may be assessed. The present systematic review aims to investigate how family functioning is assessed in this context. Following PRISMA guidelines, a total of 29 studies were reviewed. Results showed that although there was no consensual family functioning assessment across studies, 27 studies (93%) relied on self-report questionnaires, 12 studies (41%) relied on one family member as an informant (adult with bipolar disorder or other) and the adult considered was mostly a woman in the acute phase of bipolar I disorder. Significant heterogeneity was observed in the assessment of family functioning. Methodological considerations regarding the assessment of family functioning are discussed. Full article
(This article belongs to the Special Issue The Clinical Management of Bipolar Disorders)
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