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Multimodality Imaging in Cardiomyopathies
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Multimodality Imaging in Cardiomyopathies

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: closed (30 December 2022) | Viewed by 19349

Special Issue Editors

Prof. Dr. Antonello D’Andrea

E-Mail Website
Guest Editor
Department of Cardiology, Umberto I Hospital, 84014 Nocera Inferiore, SA, Italy
Interests: advanced cardiovascular imaging; CMR; echocardiography; cardiovascular emergencies
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Eduardo Bossone

E-Mail Website
Guest Editor
Division of Cardiology, Antonio Cardarelli Hospital, Naples, Italy
Interests: right heart pulmonary circulation UNIT; aorta diseases; takotsubo syndrome

Special Issue Information

Dear Colleagues,

Multimodality imaging plays an essential role in the evaluation, diagnosis and management of patients suspected of having a cardiomyopathy. In fact, multimodality imaging provides functional and anatomical information, and also variables that facilitate risk stratification and prognosis evaluation. Echocardiography with new applications such as strain imaging is the most common initial test used to establish the presence of cardiomyopathy, by depicting structural and functional abnormalities. However, echocardiographic findings are non-specific, and, therefore, have a limited role in identifying the underlying aetiology. The clinician should be capable of selecting the appropriate imaging techniques for each clinical scenario. Each technique has strengths and weaknesses, which should be known. The future of multimodality imaging in the diagnosis and management of cardiomyopathies will also involve evolution of its use in care, teaching and research.

Prof. Dr. Antonello D'Andrea
Prof. Dr. Eduardo Bossone
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Hypertrofic cardiomyopathy
  • Right ventricular dysplasia
  • Athlete’s heart
  • Dilated cardiomyopathy
  • Amyolodosis

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Published Papers (4 papers)

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Research

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16 pages, 1963 KiB  
Article
Left and Right Ventricular Morphology, Function and Myocardial Deformation in Children with Left Ventricular Non-Compaction Cardiomyopathy: A Case-Control Cardiovascular Magnetic Resonance Study
by Jędrzej Sarnecki, Agata Paszkowska, Joanna Petryka-Mazurkiewicz, Agata Kubik, Janusz Feber, Elżbieta Jurkiewicz and Lidia Ziółkowska
J. Clin. Med. 2022, 11(4), 1104; https://doi.org/10.3390/jcm11041104 - 19 Feb 2022
Cited by 11 | Viewed by 2603
Abstract
Background: Left ventricular non-compaction (LVNC) is a rare cardiomyopathy typically involving the left ventricle (LV); however, the right ventricle (RV) can also be affected. This case-control study aimed to assess the morphology and function of LV and RV in children with LVNC. [...] Read more.
Background: Left ventricular non-compaction (LVNC) is a rare cardiomyopathy typically involving the left ventricle (LV); however, the right ventricle (RV) can also be affected. This case-control study aimed to assess the morphology and function of LV and RV in children with LVNC. Methods: Sixteen children (13 ± 3 years, six girls) with LVNC were compared with 16 sex- and age-matched controls. LV and RV morphology and function were evaluated in cardiovascular magnetic resonance (CMR) studies. Additionally, LV and RV global radial (GRS), circumferential (GCS), and longitudinal strain (GLS) were assessed using tissue-tracking analysis. Results: Patients with LVNC did not differ from the healthy controls in terms of age, height, weight, and body surface area (BSA). In total, 4/16 subjects with LVNC had mid-wall late gadolinium enhancement (LGE). Compared to the control group, patients with LVNC had higher end-diastolic volume (EDV) indexed for body surface area (BSA), lower ejection fraction (EF), and lower LV strain parameters (all p < 0.05). Children with LVNC also presented with thicker RV apical trabeculation, whereas there were no differences in RV EF and EDV/BSA between the groups. Nevertheless, children with LVNC had impaired RV GRS and GCS (both p < 0.05). Conclusions: LVNC in pediatric patients is associated with LV enlargement and impaired LV systolic function. Additionally, children with LVNC have increased RV trabeculations and subclinical impairment of RV myocardial deformation. Full article
(This article belongs to the Special Issue Multimodality Imaging in Cardiomyopathies)
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Review

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15 pages, 2705 KiB  
Review
Chronic Heart Failure in Children: State of the Art and New Perspectives
by Biagio Castaldi, Elena Cuppini, Jennifer Fumanelli, Angela Di Candia, Jolanda Sabatino, Domenico Sirico, Vladimiro Vida, Massimo Padalino and Giovanni Di Salvo
J. Clin. Med. 2023, 12(7), 2611; https://doi.org/10.3390/jcm12072611 - 30 Mar 2023
Cited by 8 | Viewed by 5788
Abstract
Pediatric heart failure (HF) is an important clinical condition with high morbidity and mortality. Compared to adults, pediatric HF shows different etiologies characterized by different physiology, a different clinical course, and deeply different therapeutic approaches. In the last few years, new drugs have [...] Read more.
Pediatric heart failure (HF) is an important clinical condition with high morbidity and mortality. Compared to adults, pediatric HF shows different etiologies characterized by different physiology, a different clinical course, and deeply different therapeutic approaches. In the last few years, new drugs have been developed and new therapeutic strategies have been proposed with the goal of identifying an individualized treatment regimen. The aim of this article is to review the new potential drugs and non-pharmacological therapies for pediatric heart failure in children. Full article
(This article belongs to the Special Issue Multimodality Imaging in Cardiomyopathies)
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26 pages, 5324 KiB  
Review
New Advanced Imaging Parameters and Biomarkers—A Step Forward in the Diagnosis and Prognosis of TTR Cardiomyopathy
by Roxana Cristina Rimbas, Anca Balinisteanu, Stefania Lucia Magda, Simona Ionela Visoiu, Andrea Olivia Ciobanu, Elena Beganu, Alina Ioana Nicula and Dragos Vinereanu
J. Clin. Med. 2022, 11(9), 2360; https://doi.org/10.3390/jcm11092360 - 22 Apr 2022
Cited by 12 | Viewed by 3631
Abstract
Transthyretin amyloid cardiomyopathy (ATTR-CM) is an infiltrative disorder characterized by extracellular myocardial deposits of amyloid fibrils, with poor outcome, leading to heart failure and death, with significant treatment expenditure. In the era of a novel therapeutic arsenal of disease-modifying agents that target a [...] Read more.
Transthyretin amyloid cardiomyopathy (ATTR-CM) is an infiltrative disorder characterized by extracellular myocardial deposits of amyloid fibrils, with poor outcome, leading to heart failure and death, with significant treatment expenditure. In the era of a novel therapeutic arsenal of disease-modifying agents that target a myriad of pathophysiological mechanisms, timely and accurate diagnosis of ATTR-CM is crucial. Recent advances in therapeutic strategies shown to be most beneficial in the early stages of the disease have determined a paradigm shift in the screening, diagnostic algorithm, and risk classification of patients with ATTR-CM. The aim of this review is to explore the utility of novel specific non-invasive imaging parameters and biomarkers from screening to diagnosis, prognosis, risk stratification, and monitoring of the response to therapy. We will summarize the knowledge of the most recent advances in diagnostic, prognostic, and treatment tailoring parameters for early recognition, prediction of outcome, and better selection of therapeutic candidates in ATTR-CM. Moreover, we will provide input from different potential pathways involved in the pathophysiology of ATTR-CM, on top of the amyloid deposition, such as inflammation, endothelial dysfunction, reduced nitric oxide bioavailability, oxidative stress, and myocardial fibrosis, and their diagnostic, prognostic, and therapeutic implications. Full article
(This article belongs to the Special Issue Multimodality Imaging in Cardiomyopathies)
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15 pages, 1072 KiB  
Review
Multimodality Imaging in Cardiomyopathies with Hypertrophic Phenotypes
by Emanuele Monda, Giuseppe Palmiero, Michele Lioncino, Marta Rubino, Annapaola Cirillo, Adelaide Fusco, Martina Caiazza, Federica Verrillo, Gaetano Diana, Alfredo Mauriello, Michele Iavarone, Maria Angela Losi, Maria Luisa De Rimini, Santo Dellegrottaglie, Antonello D’Andrea, Eduardo Bossone, Giuseppe Pacileo and Giuseppe Limongelli
J. Clin. Med. 2022, 11(3), 868; https://doi.org/10.3390/jcm11030868 - 7 Feb 2022
Cited by 23 | Viewed by 5696
Abstract
Multimodality imaging is a comprehensive strategy to investigate left ventricular hypertrophy (LVH), providing morphologic, functional, and often clinical information to clinicians. Hypertrophic cardiomyopathy (HCM) is defined by an increased LV wall thickness not only explainable by abnormal loading conditions. In the context of [...] Read more.
Multimodality imaging is a comprehensive strategy to investigate left ventricular hypertrophy (LVH), providing morphologic, functional, and often clinical information to clinicians. Hypertrophic cardiomyopathy (HCM) is defined by an increased LV wall thickness not only explainable by abnormal loading conditions. In the context of HCM, multimodality imaging, by different imaging techniques, such as echocardiography, cardiac magnetic resonance, cardiac computer tomography, and cardiac nuclear imaging, provides essential information for diagnosis, sudden cardiac death stratification, and management. Furthermore, it is essential to uncover the specific cause of HCM, such as Fabry disease and cardiac amyloidosis, which can benefit of specific treatments. This review aims to elucidate the current role of multimodality imaging in adult patients with HCM. Full article
(This article belongs to the Special Issue Multimodality Imaging in Cardiomyopathies)
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