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Special Issue "Multimodality Imaging in Cardiomyopathies"

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A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: closed (30 December 2022) | Viewed by 11582

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Special Issue Editors

Prof. Dr. Antonello D'Andrea

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Guest Editor

Department of Cardiology, Umberto I Hospital, 84014 Nocera Inferiore, SA, Italy
Interests: echocardiography; cardiomyopathies; heart failure; athlete’s heart; spackle tracking strain; stress echocardiography
Special Issues, Collections and Topics in MDPI journals

Prof. Dr. Eduardo Bossone

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Guest Editor

Division of Cardiology, Antonio Cardarelli Hospital, Naples, Italy
Interests: right heart pulmonary circulation UNIT; aorta diseases; takotsubo syndrome

Special Issue Information

Dear Colleagues,

Multimodality imaging plays an essential role in the evaluation, diagnosis and management of patients suspected of having a cardiomyopathy. In fact, multimodality imaging provides functional and anatomical information, and also variables that facilitate risk stratification and prognosis evaluation. Echocardiography with new applications such as strain imaging is the most common initial test used to establish the presence of cardiomyopathy, by depicting structural and functional abnormalities. However, echocardiographic findings are non-specific, and, therefore, have a limited role in identifying the underlying aetiology. The clinician should be capable of selecting the appropriate imaging techniques for each clinical scenario. Each technique has strengths and weaknesses, which should be known. The future of multimodality imaging in the diagnosis and management of cardiomyopathies will also involve evolution of its use in care, teaching and research.

Prof. Dr. Antonello D'Andrea
Prof. Dr. Eduardo Bossone
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

Hypertrofic cardiomyopathy
Right ventricular dysplasia
Athlete’s heart
Dilated cardiomyopathy
Amyolodosis

Published Papers (5 papers)

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Research

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Open AccessArticle

Left and Right Ventricular Morphology, Function and Myocardial Deformation in Children with Left Ventricular Non-Compaction Cardiomyopathy: A Case-Control Cardiovascular Magnetic Resonance Study

Jędrzej Sarnecki

Agata Paszkowska

Joanna Petryka-Mazurkiewicz

and

J. Clin. Med. 2022, 11(4), 1104; https://doi.org/10.3390/jcm11041104 - 19 Feb 2022

Cited by 5 | Viewed by 1513

Abstract

Background: Left ventricular non-compaction (LVNC) is a rare cardiomyopathy typically involving the left ventricle (LV); however, the right ventricle (RV) can also be affected. This case-control study aimed to assess the morphology and function of LV and RV in children with LVNC. Methods: Sixteen children (13 ± 3 years, six girls) with LVNC were compared with 16 sex- and age-matched controls. LV and RV morphology and function were evaluated in cardiovascular magnetic resonance (CMR) studies. Additionally, LV and RV global radial (GRS), circumferential (GCS), and longitudinal strain (GLS) were assessed using tissue-tracking analysis. Results: Patients with LVNC did not differ from the healthy controls in terms of age, height, weight, and body surface area (BSA). In total, 4/16 subjects with LVNC had mid-wall late gadolinium enhancement (LGE). Compared to the control group, patients with LVNC had higher end-diastolic volume (EDV) indexed for body surface area (BSA), lower ejection fraction (EF), and lower LV strain parameters (all p < 0.05). Children with LVNC also presented with thicker RV apical trabeculation, whereas there were no differences in RV EF and EDV/BSA between the groups. Nevertheless, children with LVNC had impaired RV GRS and GCS (both p < 0.05). Conclusions: LVNC in pediatric patients is associated with LV enlargement and impaired LV systolic function. Additionally, children with LVNC have increased RV trabeculations and subclinical impairment of RV myocardial deformation. Full article

(This article belongs to the Special Issue Multimodality Imaging in Cardiomyopathies)

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Review

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Open AccessReview

Chronic Heart Failure in Children: State of the Art and New Perspectives

and

J. Clin. Med. 2023, 12(7), 2611; https://doi.org/10.3390/jcm12072611 - 30 Mar 2023

Cited by 1 | Viewed by 1454

Abstract

Pediatric heart failure (HF) is an important clinical condition with high morbidity and mortality. Compared to adults, pediatric HF shows different etiologies characterized by different physiology, a different clinical course, and deeply different therapeutic approaches. In the last few years, new drugs have been developed and new therapeutic strategies have been proposed with the goal of identifying an individualized treatment regimen. The aim of this article is to review the new potential drugs and non-pharmacological therapies for pediatric heart failure in children. Full article

(This article belongs to the Special Issue Multimodality Imaging in Cardiomyopathies)

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Open AccessReview

New Advanced Imaging Parameters and Biomarkers—A Step Forward in the Diagnosis and Prognosis of TTR Cardiomyopathy

Roxana Cristina Rimbas

Anca Balinisteanu

Stefania Lucia Magda

Simona Ionela Visoiu

Andrea Olivia Ciobanu

Elena Beganu

Alina Ioana Nicula

and

Dragos Vinereanu

J. Clin. Med. 2022, 11(9), 2360; https://doi.org/10.3390/jcm11092360 - 22 Apr 2022

Cited by 3 | Viewed by 1934

Abstract

Transthyretin amyloid cardiomyopathy (ATTR-CM) is an infiltrative disorder characterized by extracellular myocardial deposits of amyloid fibrils, with poor outcome, leading to heart failure and death, with significant treatment expenditure. In the era of a novel therapeutic arsenal of disease-modifying agents that target a myriad of pathophysiological mechanisms, timely and accurate diagnosis of ATTR-CM is crucial. Recent advances in therapeutic strategies shown to be most beneficial in the early stages of the disease have determined a paradigm shift in the screening, diagnostic algorithm, and risk classification of patients with ATTR-CM. The aim of this review is to explore the utility of novel specific non-invasive imaging parameters and biomarkers from screening to diagnosis, prognosis, risk stratification, and monitoring of the response to therapy. We will summarize the knowledge of the most recent advances in diagnostic, prognostic, and treatment tailoring parameters for early recognition, prediction of outcome, and better selection of therapeutic candidates in ATTR-CM. Moreover, we will provide input from different potential pathways involved in the pathophysiology of ATTR-CM, on top of the amyloid deposition, such as inflammation, endothelial dysfunction, reduced nitric oxide bioavailability, oxidative stress, and myocardial fibrosis, and their diagnostic, prognostic, and therapeutic implications. Full article

(This article belongs to the Special Issue Multimodality Imaging in Cardiomyopathies)

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Open AccessEditor’s ChoiceReview

Multimodality Imaging in Cardiomyopathies with Hypertrophic Phenotypes

Maria Luisa De Rimini

Santo Dellegrottaglie

and

J. Clin. Med. 2022, 11(3), 868; https://doi.org/10.3390/jcm11030868 - 07 Feb 2022

Cited by 16 | Viewed by 2967

Abstract

Multimodality imaging is a comprehensive strategy to investigate left ventricular hypertrophy (LVH), providing morphologic, functional, and often clinical information to clinicians. Hypertrophic cardiomyopathy (HCM) is defined by an increased LV wall thickness not only explainable by abnormal loading conditions. In the context of HCM, multimodality imaging, by different imaging techniques, such as echocardiography, cardiac magnetic resonance, cardiac computer tomography, and cardiac nuclear imaging, provides essential information for diagnosis, sudden cardiac death stratification, and management. Furthermore, it is essential to uncover the specific cause of HCM, such as Fabry disease and cardiac amyloidosis, which can benefit of specific treatments. This review aims to elucidate the current role of multimodality imaging in adult patients with HCM. Full article

(This article belongs to the Special Issue Multimodality Imaging in Cardiomyopathies)

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Open AccessReview

The Role of Multimodality Imaging in Athlete’s Heart Diagnosis: Current Status and Future Directions

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J. Clin. Med. 2021, 10(21), 5126; https://doi.org/10.3390/jcm10215126 - 31 Oct 2021

Cited by 14 | Viewed by 2498

Abstract

“Athlete’s heart” is a spectrum of morphological and functional changes which occur in the heart of people who practice physical activity. When athlete’s heart occurs with its most marked expression, it may overlap with a differential diagnosis with certain structural cardiac diseases, including cardiomyopathies, valvular diseases, aortopathies, myocarditis, and coronary artery anomalies. Identifying the underlying cardiac is essential to reduce the potential for sudden cardiac death. For this purpose, a spectrum of imaging modalities, including rest and exercise stress echocardiography, speckle tracking echocardiography, cardiac magnetic resonance, computed tomography, and nuclear scintigraphy, can be undertaken. The objective of this review article is to provide to the clinician a practical step-by-step approach, aiming at distinguishing between extreme physiology and structural cardiac disease during the athlete’s cardiovascular evaluation. Full article

(This article belongs to the Special Issue Multimodality Imaging in Cardiomyopathies)

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