Next Article in Journal
New Opportunities and Challenges of Early Psychosis
Previous Article in Journal
Cystic Kidney Diseases That Require a Differential Diagnosis from Autosomal Dominant Polycystic Kidney Disease (ADPKD)
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
JCM
Volume 11
Issue 21
10.3390/jcm11216530
jcm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Low FT3/FT4 Ratio Is Linked to Poor Prognosis of Acute Myocardial Infarction in Euthyroid Patients with Type 2 Diabetes Mellitus

by
Xi He
1,†,
Ruonan Gao
2,†,
Yubin Wu
2,
Kejun Wu
2,
Jianmin Sun
1,
Xintao Zhang
1,
Libin Liu
2,* and
Lianglong Chen
1,*
1
Department of Cardiology, Fujian Institute of Coronary Artery Disease, Fujian Medical University Union Hospital, Fuzhou 350001, China
2
Department of Endocrinology, Fujian Medical University Union Hospital, Fuzhou 350001, China
*
Authors to whom correspondence should be addressed.
†
The authors share the first authorship.
J. Clin. Med. 2022, 11(21), 6530; https://doi.org/10.3390/jcm11216530
Submission received: 28 September 2022 / Revised: 30 October 2022 / Accepted: 1 November 2022 / Published: 3 November 2022
(This article belongs to the Section Endocrinology & Metabolism)
Browse Figures
Versions Notes

Abstract

This is an observational, retrospective, single-center study aimed to determine whether the free triiodothyronine (FT3) to free thyroxine (FT4) ratio was related to acute myocardial infarction (AMI) prognosis in individuals with type 2 diabetes mellitus (T2DM). A total of 294 euthyroid T2DM patients with new-onset AMI were enrolled. FT3/FT4 ratio tertiles were used to categorize patients into Group 1 (FT3/FT4 ≥ 4.3), Group 2 (3.5 ≤ FT3/FT4 < 4.3), and Group 3 (FT3/FT4 < 3.5). Major adverse cardiac events (MACE), including nonfatal myocardial infarction, target vessel revascularization (TVR), and cardiac mortality, served as the primary endpoint. Group 3 demonstrated a considerably higher incidence of MACE than the other two groups over the average follow-up duration of 21 ± 6.5 months (all p < 0.001). Multivariable Cox regression analysis showed that a low FT3/FT4 ratio was an independent risk factor for MACE after AMI (Group 1 as a reference; Group 2: hazard ratio [HR] 1.275, 95% confidence interval [CI]: 0.563–2.889, p = 0.561; Group 3: HR 2.456, 95% CI: 1.105–5.459, p = 0.027). Moreover, the area under the receiver-operating characteristic curve (AUC) indicates a good predictive value of FT3/FT4 ratio for MACE (AUC = 0.70). Therefore, in T2DM patients with AMI, a low FT3/FT4 ratio was strongly linked to poor prognosis.
Keywords: FT3/FT4; type 2 diabetes mellitus; acute myocardial infarction; major adverse cardiac event; clinical outcome FT3/FT4; type 2 diabetes mellitus; acute myocardial infarction; major adverse cardiac event; clinical outcome

Share and Cite

MDPI and ACS Style

He, X.; Gao, R.; Wu, Y.; Wu, K.; Sun, J.; Zhang, X.; Liu, L.; Chen, L. Low FT3/FT4 Ratio Is Linked to Poor Prognosis of Acute Myocardial Infarction in Euthyroid Patients with Type 2 Diabetes Mellitus. J. Clin. Med. 2022, 11, 6530. https://doi.org/10.3390/jcm11216530

AMA Style

He X, Gao R, Wu Y, Wu K, Sun J, Zhang X, Liu L, Chen L. Low FT3/FT4 Ratio Is Linked to Poor Prognosis of Acute Myocardial Infarction in Euthyroid Patients with Type 2 Diabetes Mellitus. Journal of Clinical Medicine. 2022; 11(21):6530. https://doi.org/10.3390/jcm11216530

Chicago/Turabian Style

He, Xi, Ruonan Gao, Yubin Wu, Kejun Wu, Jianmin Sun, Xintao Zhang, Libin Liu, and Lianglong Chen. 2022. "Low FT3/FT4 Ratio Is Linked to Poor Prognosis of Acute Myocardial Infarction in Euthyroid Patients with Type 2 Diabetes Mellitus" Journal of Clinical Medicine 11, no. 21: 6530. https://doi.org/10.3390/jcm11216530

APA Style

He, X., Gao, R., Wu, Y., Wu, K., Sun, J., Zhang, X., Liu, L., & Chen, L. (2022). Low FT3/FT4 Ratio Is Linked to Poor Prognosis of Acute Myocardial Infarction in Euthyroid Patients with Type 2 Diabetes Mellitus. Journal of Clinical Medicine, 11(21), 6530. https://doi.org/10.3390/jcm11216530

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop