Next Article in Journal
Community-Acquired Pneumonia among Patients with COPD in Spain from 2016 to 2019. Cohort Study Assessing Sex Differences in the Incidence and Outcomes Using Hospital Discharge Data
Previous Article in Journal
Cross-Cultural Adaptation, Reliability, and Psychophysical Validation of the Pain and Sleep Questionnaire Three-Item Index in Finnish
Previous Article in Special Issue
Prognostic Value of N-Terminal Pro-Brain Natriuretic Peptide and High-Sensitivity Troponin T Levels in the Natural History of Transthyretin Amyloid Cardiomyopathy and Their Evolution after Tafamidis Treatment
Article

Echocardiographic Patterns of Left Ventricular Diastolic Function in Cardiac Amyloidosis: An Updated Evaluation

by 1,2,3,4,*, 5,6, 1,2,3,4,7, 1,2,3,4,7, 1,2,3,4, 1,2,3,4, 1,2,3,4,7, 2,3,8, 2,3,7,9, 2,3,7,10, 2,3,7,11, 2,3,7,12, 1,2,3,4,7, 13,14, 1,2,3,4,7 and 1,2,3,7,15
1
French Referral Centre for Cardiac Amyloidosis, Henri Mondor Teaching Hospital, APHP, 1, Rue Gustave Eiffel, 94010 Creteil, France
2
GRC Amyloid Research Institute, Henri Mondor Teaching Hospital, APHP, 1, Rue Gustave Eiffel, 94010 Creteil, France
3
Amyloidosis Mondor Network, Henri Mondor Teaching Hospital, APHP, 1, Rue Gustave Eiffel, 94010 Creteil, France
4
Cardiology Department, APHP, Henri Mondor Teaching Hospital, 94010 Creteil, France
5
Paris Cardiovascular Research Centre (PARCC), INSERM Unit 970, 56, Rue Leblanc, 75015 Paris, France
6
Ramsay Générale de Santé, Hôpital Privé Jacques Cartier, 6, Av du Noyer Lambert, 91300 Massy, France
7
IMRB-INSERM U955, Henri Mondor Teaching Hospital, APHP, 1, Rue Gustave Eiffel, 94010 Creteil, France
8
Lymphoid Malignancies Unit, Henri Mondor Teaching Hospital, APHP, 1, Rue Gustave Eiffel, 94010 Creteil, France
9
Radiology Department, Henri Mondor Teaching Hospital, APHP, 1, Rue Gustave Eiffel, 94010 Creteil, France
10
Nuclear Medicine, Henri Mondor Teaching Hospital, APHP, 1, Rue Gustave Eiffel, 94010 Creteil, France
11
Pathology Department, Henri Mondor Teaching Hospital, APHP, 1, Rue Gustave Eiffel, 94010 Creteil, France
12
Genetic Department, Henri Mondor Teaching Hospital, APHP, 1, Rue Gustave Eiffel, 94010 Creteil, France
13
Referral Centre for AL and Cardiology Department, CHU Dupuytren, 16, rue Bernard Descottes, 87042 Limoges, France
14
King Faisal Specialist Hospital & Research Centre, Heart Centre, Al Faysal University, Riyadh 112111, Saudi Arabia
15
Cardiology Outpatients Unit, Centre Cardiologique du Nord, 32-36 Rue des Moulins Gémeaux, 93200 Saint Denis, France
*
Author to whom correspondence should be addressed.
Academic Editor: Olivier Lairez
J. Clin. Med. 2021, 10(21), 4888; https://doi.org/10.3390/jcm10214888
Received: 22 September 2021 / Revised: 16 October 2021 / Accepted: 19 October 2021 / Published: 23 October 2021
(This article belongs to the Special Issue Diagnosis and Management of Cardiac Amyloidosis)
Aims: Multimodal imaging has allowed cardiac amyloidosis (CA) to be increasingly recognised as a treatable cause of heart failure with preserved ejection fraction, but its prognosis remains poor due to late diagnosis. To assess the left ventricular diastolic function (LVDF) patterns in a large contemporary CA cohort according to the current recommendations and to identify their determinants. Methods and Results: We conducted a monocentric, observational study on a cohort of CA patients from a tertiary CA referral centre. Diastolic function was analysed using standard echocardiography and clinical, laboratory and survival parameters were collected. Four hundred and sixty-four patients with one of the three main type of CA were included: 41% had grade III diastolic dysfunction (restrictive mitral pattern), 25% had grade II diastolic dysfunction, and 25% had grade I diastolic dysfunction; 9% were unclassified. No difference was found between the main CA types. After multivariate analyses, grades II and III were independently associated with dyspnoea, elevated NT-proBNP, cardiac infiltration and systolic dysfunction (global longitudinal strain). Grade I patients had a better prognosis. Conclusions: All LVDF patterns can be observed in CA. One quarter of CA patients have grade I LVDF, reflecting the emergence of earlier stage-related phenotypes with a better prognosis. View Full-Text
Keywords: cardiac amyloidosis; heart failure; diastolic function; echocardiography; guidelines cardiac amyloidosis; heart failure; diastolic function; echocardiography; guidelines
Show Figures

Figure 1

MDPI and ACS Style

Oghina, S.; Bougouin, W.; Kharoubi, M.; Bonnefous, L.; Galat, A.; Guendouz, S.; Bezard, M.; Le Bras, F.; Deux, J.-F.; Itti, E.; Moktefi, A.; Fanen, P.; Teiger, E.; Mohty, D.; Damy, T.; Bodez, D. Echocardiographic Patterns of Left Ventricular Diastolic Function in Cardiac Amyloidosis: An Updated Evaluation. J. Clin. Med. 2021, 10, 4888. https://doi.org/10.3390/jcm10214888

AMA Style

Oghina S, Bougouin W, Kharoubi M, Bonnefous L, Galat A, Guendouz S, Bezard M, Le Bras F, Deux J-F, Itti E, Moktefi A, Fanen P, Teiger E, Mohty D, Damy T, Bodez D. Echocardiographic Patterns of Left Ventricular Diastolic Function in Cardiac Amyloidosis: An Updated Evaluation. Journal of Clinical Medicine. 2021; 10(21):4888. https://doi.org/10.3390/jcm10214888

Chicago/Turabian Style

Oghina, Silvia, Wulfran Bougouin, Mounira Kharoubi, Louis Bonnefous, Arnault Galat, Soulef Guendouz, Mélanie Bezard, Fabien Le Bras, Jean-François Deux, Emmanuel Itti, Anissa Moktefi, Pascale Fanen, Emmanuel Teiger, Dania Mohty, Thibaud Damy, and Diane Bodez. 2021. "Echocardiographic Patterns of Left Ventricular Diastolic Function in Cardiac Amyloidosis: An Updated Evaluation" Journal of Clinical Medicine 10, no. 21: 4888. https://doi.org/10.3390/jcm10214888

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop