- 3.4Impact Factor
- 9.9CiteScore
- 20 daysTime to First Decision
Vaccines, Volume 10, Issue 1
January 2022 - 135 articles
Cover Story: The process of immune-informatics-based MHC peptide vaccine design generally involves the consideration of a few relevant parameters, such as peptide binding affinity and immunogenicity. However, many vaccines that are effective in silico can fail in preclinical or clinical trials due to not accounting for other clinical properties. We have identified several clinical variables that are relevant in the design of effective peptide vaccines: binding affinity, immunogenicity, antigenicity, half-life, toxicity, IFNγ release, and instability. We developed an epitope selection method that incorporates these clinical parameters and used the method to develop an HRAS-targeting epitope vaccine for squamous cell carcinoma. This method can be widely applicable to design a durable vaccine for other diseases. View this paper
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Vaccines - ISSN 2076-393XCreative Common CC BY license