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Vaccines, Volume 11, Issue 5

May 2023 - 132 articles

Cover Story: Tropical diseases caused by filarial nematodes such as lymphatic filariasis (elephantiasis) and onchocerciasis (river blindness) affect hundreds of millions of people worldwide. Despite decades of research, no vaccines against any filaria or helminths in general are available for use in human patients as of 2023. In this study by Scheunemann et al., the use of nucleic acid receptor agonists as potential vaccine adjuvants for filarial infections was evaluated in the Litomosoides sigmodontis rodent model. The authors reported that the use of poly(I:C), a TLR-3, MDA5, RIG-I ligand, and 3pRNA, a RIG-I ligand, improved the protective efficacy in comparison to the vaccination with irradiated L3 larvae alone and elicited stronger parasite-specific immune responses, highlighting the use of nucleic acid receptor agonists as promising vaccine strategies for filarial and other helminth infections. View this paper
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Articles (132)

  • Review
  • Open Access
22 Citations
6,996 Views
23 Pages

Vaccines against Tuberculosis: Where Are We Now?

  • Shruti Srivastava,
  • Sajal Dey and
  • Sangita Mukhopadhyay

22 May 2023

Tuberculosis (TB) is among the top 10 leading causes of death in low-income countries. Statistically, TB kills more than 30,000 people each week and leads to more deaths than any other infectious disease, such as acquired immunodeficiency syndrome (A...

  • Article
  • Open Access
6 Citations
2,874 Views
16 Pages

A Third Dose of SARS-CoV-2 mRNA Vaccine Improves Immune Response in Chronic Kidney Disease Patients

  • Maria Cecilia Poli,
  • Cecilia Vial,
  • Emma Rey-Jurado,
  • Natalia González,
  • Lina Jimena Cortés,
  • Juan Hormazabal,
  • Carolina Ramírez-Riffo,
  • Javiera de la Cruz and
  • Camilo Ulloa

22 May 2023

Chronic kidney disease (CKD) patients have an increased risk of morbidity and mortality following SARS-CoV-2 infection. Vaccination in these patients is prioritized, and monitoring of the immune response is paramount to define further vaccination str...

  • Systematic Review
  • Open Access
20 Citations
4,492 Views
24 Pages

The Impact of Vaccination on COVID-19 Burden of Disease in the Adult and Elderly Population: A Systematic Review of Italian Evidence

  • Giovanna Elisa Calabrò,
  • Ciro Pappalardo,
  • Floriana D’Ambrosio,
  • Michele Vece,
  • Chiara Lupi,
  • Alberto Lontano,
  • Mattia Di Russo,
  • Roberto Ricciardi and
  • Chiara de Waure

22 May 2023

COVID-19 is a major global health threat, with millions of confirmed cases and deaths worldwide. Containment and mitigation strategies, including vaccination, have been implemented to reduce transmission and protect the population. We conducted two s...

  • Article
  • Open Access
18 Citations
5,794 Views
14 Pages

COVID-19 Vaccination in the WHO African Region: Progress Made in 2022 and Factors Associated

  • Franck Mboussou,
  • Bridget Farham,
  • Sheillah Nsasiirwe,
  • Ajiri Atagbaza,
  • Daniel Oyaole,
  • Phionah Lynn Atuhebwe,
  • Victor Alegana,
  • Fred Osei-sarpong,
  • Ado Bwaka and
  • Gilson Paluku
  • + 5 authors

22 May 2023

This study summarizes progress made in rolling out COVID-19 vaccinations in the African region in 2022, and analyzes factors associated with vaccination coverage. Data on vaccine uptake reported to the World Health Organization (WHO) Regional Office...

  • Article
  • Open Access
2 Citations
2,839 Views
11 Pages

22 May 2023

China is relaxing COVID-19 measures from the “dynamic zero tolerance” (DZT) level. The “flatten-the-curve” (FTC) strategy, which decreases and maintains the low rate of infection to avoid overwhelming the healthcare system by...

  • Article
  • Open Access
11 Citations
3,305 Views
15 Pages

Perceptions and Intention to Get Vaccinated against Mpox among the LGBTIQ+ Community during the 2022 Outbreak: A Cross-Sectional Study in Peru

  • Julieta M. Araoz-Salinas,
  • Brando Ortiz-Saavedra,
  • Linda Ponce-Rosas,
  • David R. Soriano-Moreno,
  • Anderson N. Soriano-Moreno,
  • Jorge Alave and
  • Jose A. Gonzales-Zamora

21 May 2023

Vaccination against mpox can control the outbreak by targeting high-risk groups such as the LGBTIQ+ community. The aim of the study was to evaluate the perceptions and intentions to get vaccinated against mpox among the LGBTIQ+ community in Peru. We...

  • Article
  • Open Access
5 Citations
2,874 Views
13 Pages

21 May 2023

Understanding the immunological mechanisms of protection and the viral proteins involved in the induction of a protective immune response to the African swine fever virus (ASFV) is still limited. In the last years, the CD2v protein (gp110-140) of the...

  • Article
  • Open Access
10 Citations
4,030 Views
24 Pages

Vaccinia Virus Strain MVA Expressing a Prefusion-Stabilized SARS-CoV-2 Spike Glycoprotein Induces Robust Protection and Prevents Brain Infection in Mouse and Hamster Models

  • María M. Lorenzo,
  • Alejandro Marín-López,
  • Kevin Chiem,
  • Luis Jimenez-Cabello,
  • Irfan Ullah,
  • Sergio Utrilla-Trigo,
  • Eva Calvo-Pinilla,
  • Gema Lorenzo,
  • Sandra Moreno and
  • Chengjin Ye
  • + 12 authors

21 May 2023

The COVID-19 pandemic has underscored the importance of swift responses and the necessity of dependable technologies for vaccine development. Our team previously developed a fast cloning system for the modified vaccinia virus Ankara (MVA) vaccine pla...

  • Article
  • Open Access
7 Citations
3,294 Views
16 Pages

Bovine Herpesvirus-4 Based Vaccine Provides Protective Immunity against Streptococcus suis Disease in a Rabbit Model

  • Nihua Dong,
  • Hester Nichols,
  • Qing Sun,
  • Xiaojun Chen,
  • Jiayang Zheng,
  • Zhixin Guan,
  • Hailong Zhang,
  • Andrew Davison,
  • Yvonne Wezel and
  • Zongjie Li
  • + 10 authors

20 May 2023

Streptococcus suis (S. suis) is a bacterial pathogen of pigs that has a major animal health and economic impact on the pig industry. Bovine herpesvirus-4 (BoHV-4) is a new virus-based vaccine vector that has been used for the immunogenic delivery of...

  • Article
  • Open Access
9 Citations
6,055 Views
13 Pages

A Booster with a Genotype-Matched Inactivated Newcastle Disease Virus (NDV) Vaccine Candidate Provides Better Protection against a Virulent Genotype XIII.2 Virus

  • Ismail Hossain,
  • Jannatul Ferdous Subarna,
  • Congriev Kumar Kabiraj,
  • Jahan Ara Begum,
  • Rokshana Parvin,
  • Mathias Martins,
  • Diego G. Diel,
  • Emdadul Haque Chowdhury,
  • Mohammad Rafiqul Islam and
  • Mohammed Nooruzzaman

20 May 2023

Newcastle disease (ND) is endemic in Bangladesh. Locally produced or imported live Newcastle disease virus (NDV) vaccines based on lentogenic virus strains, locally produced live vaccines of the mesogenic Mukteswar strain, as well as imported inactiv...

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Vaccines - ISSN 2076-393X