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Antioxidants, Volume 9, Issue 12

December 2020 - 143 articles

Cover Story: The present review deals with reactive oxygen and nitrogen species, as they have emerged over the past centuries. It describes their discovery in biological systems, their metabolic fate, their role in host defense, their pathogenic potential, and their physiological role in redox regulation and signaling. The article ends with a critical discussion of the inflationary use of poorly defined terms such as ROS, NOS, antioxidants, and stress. View this paper
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Articles (143)

  • Article
  • Open Access
56 Citations
8,529 Views
21 Pages

17 December 2020

Chilling injury (CI) is a postharvest disorder occurring in the fruit of cold-sensitive Citrus species during storage at low temperatures. This study investigated the involvement of carotenoids and vitamin C, two major antioxidants of citrus peel, an...

  • Review
  • Open Access
55 Citations
7,868 Views
22 Pages

The Writers, Readers, and Erasers in Redox Regulation of GAPDH

  • Maria-Armineh Tossounian,
  • Bruce Zhang and
  • Ivan Gout

16 December 2020

Glyceraldehyde 3–phosphate dehydrogenase (GAPDH) is a key glycolytic enzyme, which is crucial for the breakdown of glucose to provide cellular energy. Over the past decade, GAPDH has been reported to be one of the most prominent cellular target...

  • Article
  • Open Access
59 Citations
10,601 Views
16 Pages

Assessment of Rosemary (Rosmarinus officinalis L.) Extract as Antioxidant in Jelly Candies Made with Fructan Fibres and Stevia

  • Cristina Cedeño-Pinos,
  • Magdalena Martínez-Tomé,
  • María Antonia Murcia,
  • María José Jordán and
  • Sancho Bañón

16 December 2020

Enrichment with rosemary antioxidants is proposed as a possible strategy to obtain healthier jelly candies. Two aqueous rosemary extracts (RE) containing 73.9 (RE74) and 145.6 (RE146) mg polyphenols per g fresh weight were assessed as antioxidants in...

  • Article
  • Open Access
23 Citations
3,843 Views
18 Pages

Radical Scavenging-Linked Anti-Adipogenic Activity of Aster scaber Ethanolic Extract and Its Bioactive Compound

  • Ye-Eun Choi,
  • Sun-Il Choi,
  • Xionggao Han,
  • Xiao Men,
  • Gill-Woong Jang,
  • Hee-Yeon Kwon,
  • Seong-Ran Kang,
  • Jin-Soo Han and
  • OK-Hwan Lee

16 December 2020

Aster scaber is a wild vegetable cultivated in Korea and is known to contain phytochemicals with various biological activities. The potential antioxidant and anti-obesity effects of A. scaber and their mechanism are yet to be reported. We evaluated t...

  • Article
  • Open Access
18 Citations
3,935 Views
13 Pages

Effect of Rosmarinic Acid and Ionizing Radiation on Glutathione in Melanoma B16F10 Cells: A Translational Opportunity

  • Amparo Olivares,
  • Miguel Alcaraz-Saura,
  • Daniel Gyingiri Achel and
  • Miguel Alcaraz

16 December 2020

To explain a paradoxical radiosensitizing effect of rosmarinic acid (RA) on the melanoma B16F10 cells, we analyzed the glutathione (GSH) intracellular production on this cell (traditionally considered radioresistant) in comparison with human prostate...

  • Article
  • Open Access
29 Citations
4,856 Views
15 Pages

Protective Effect of Antioxidants in Nitric Oxide/COX-2 Interaction during Inflammatory Pain: The Role of Nitration

  • Sara Ilari,
  • Concetta Dagostino,
  • Valentina Malafoglia,
  • Filomena Lauro,
  • Luigino Antonio Giancotti,
  • Antonella Spila,
  • Stefania Proietti,
  • Domenica Ventrice,
  • Milena Rizzo and
  • Micaela Gliozzi
  • + 5 authors

16 December 2020

In clinical practice, inflammatory pain is an important, unresolved health problem, despite the utilization of non-steroidal anti-inflammatory drugs (NSAIDs). In the last decade, different studies have proven that reactive oxygen species (ROS) and re...

  • Review
  • Open Access
65 Citations
11,465 Views
20 Pages

N-Acetyl Cysteine Targets Hepatic Lipid Accumulation to Curb Oxidative Stress and Inflammation in NAFLD: A Comprehensive Analysis of the Literature

  • Phiwayinkosi V. Dludla,
  • Bongani B. Nkambule,
  • Sithandiwe E. Mazibuko-Mbeje,
  • Tawanda M. Nyambuya,
  • Fabio Marcheggiani,
  • Ilenia Cirilli,
  • Khanyisani Ziqubu,
  • Samukelisiwe C. Shabalala,
  • Rabia Johnson and
  • Johan Louw
  • + 2 authors

16 December 2020

Impaired adipose tissue function and insulin resistance remain instrumental in promoting hepatic lipid accumulation in conditions of metabolic syndrome. In fact, enhanced lipid accumulation together with oxidative stress and an abnormal inflammatory...

  • Article
  • Open Access
46 Citations
5,661 Views
27 Pages

Chemical Profiling, Antioxidant, Cytotoxic Activities and Molecular Docking Simulation of Carrichtera annua DC. (Cruciferae)

  • Enas E. Eltamany,
  • Sameh S. Elhady,
  • Haidy A. Ahmed,
  • Jihan M. Badr,
  • Ahmad O. Noor,
  • Safwat A. Ahmed and
  • Mohamed S. Nafie

16 December 2020

Our investigation intended to analyze the chemical composition and the antioxidant activity of Carrichtera annua and to evaluate the antiproliferative effect of C. annua crude and phenolics extracts by MTT assay on a panel of cancerous and non-cancer...

  • Article
  • Open Access
19 Citations
6,667 Views
16 Pages

Spontaneous Formation of Melanin from Dopamine in the Presence of Iron

  • David M. Hedges,
  • Jordan T. Yorgason,
  • Andrew W. Perez,
  • Nathan D. Schilaty,
  • Benjamin M. Williams,
  • Richard K. Watt and
  • Scott C. Steffensen

16 December 2020

Parkinson’s disease is associated with degeneration of neuromelanin (NM)-containing substantia nigra dopamine (DA) neurons and subsequent decreases in striatal DA transmission. Dopamine spontaneously forms a melanin through a process called mel...

  • Article
  • Open Access
16 Citations
6,060 Views
10 Pages

16 December 2020

Prospective studies and randomized controlled trials elucidating the impact of antioxidants supplementation on mortality risk are inconclusive. The present analysis determined association between regular antioxidants use and all-cause (primary object...

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Antioxidants - ISSN 2076-3921