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Antioxidants, Volume 7, Issue 1

January 2018 - 21 articles

Cover Story: We have previously shown that the DHHC6 enzyme binds to selenoprotein K (SELENOK) in the endoplasmic reticulum membrane to catalyze the post-translational palmitoylation of several proteins. Herein, we reveal that the selenocysteine residue in SELENOK (Sec92) functions to stabilize the palmitoylated DHHC6 intermediate by protecting the thioester bond between the palmitate and cysteine residue in DHHC6 from hydrolysis. This allows transfer of the palmitate from DHHC6 to cysteine residues on target proteins, thereby increasing the catalytic efficiency of this reaction. View the paper here.
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Articles (21)

  • Article
  • Open Access
21 Citations
9,098 Views
10 Pages

Effect of the Extraction Process on the Biological Activity of Lyophilized Apricot Extracts Recovered from Apricot Pomace

  • Dina Cheaib,
  • Nada El Darra,
  • Hiba N. Rajha,
  • Iman El-Ghazzawi,
  • Richard G. Maroun and
  • Nicolas Louka

14 January 2018

The preservation of polyphenols in fruits by lyophilization has gained great interest in the recent decades. The present study aims to assess the impact of the pre-treatment extraction methods heat-assisted extraction (HAE) and infrared (IR) on lyoph...

  • Review
  • Open Access
62 Citations
11,136 Views
20 Pages

Long-Chain Metabolites of Vitamin E: Metabolic Activation as a General Concept for Lipid-Soluble Vitamins?

  • Martin Schubert,
  • Stefan Kluge,
  • Lisa Schmölz,
  • Maria Wallert,
  • Francesco Galli,
  • Marc Birringer and
  • Stefan Lorkowski

12 January 2018

Vitamins E, A, D and K comprise the class of lipid-soluble vitamins. For vitamins A and D, a metabolic conversion of precursors to active metabolites has already been described. During the metabolism of vitamin E, the long-chain metabolites (LCMs) 13...

  • Review
  • Open Access
108 Citations
16,990 Views
21 Pages

Exercise and Mitochondrial Dynamics: Keeping in Shape with ROS and AMPK

  • Adam J. Trewin,
  • Brandon J. Berry and
  • Andrew P. Wojtovich

Exercise is a robust stimulus for mitochondrial adaptations in skeletal muscle which consequently plays a central role in enhancing metabolic health. Despite this, the precise molecular events that underpin these beneficial effects remain elusive. In...

  • Review
  • Open Access
52 Citations
8,203 Views
9 Pages

Genotypic and Environmental Effects on Tocopherol Content in Almond

  • Ossama Kodad,
  • Rafel Socias i Company and
  • José M. Alonso

Almond is the most important nut species worldwide and almond kernels show the highest levels of tocopherols among all nuts. In almond, tocopherols not only play a substantial role as a healthy food for human consumption, but also in protecting lipid...

  • Review
  • Open Access
145 Citations
14,584 Views
16 Pages

We report on studies of reactions of singlet oxygen with carotenoids and retinoids and a range of free radical studies on carotenoids and retinoids with emphasis on recent work, dietary carotenoids and the role of oxygen in biological processes. Many...

  • Review
  • Open Access
205 Citations
27,968 Views
21 Pages

Natural Nanoparticles: A Particular Matter Inspired by Nature

  • Sharoon Griffin,
  • Muhammad Irfan Masood,
  • Muhammad Jawad Nasim,
  • Muhammad Sarfraz,
  • Azubuike Peter Ebokaiwe,
  • Karl-Herbert Schäfer,
  • Cornelia M. Keck and
  • Claus Jacob

29 December 2017

During the last couple of decades, the rapidly advancing field of nanotechnology has produced a wide palette of nanomaterials, most of which are considered as “synthetic” and, among the wider public, are often met with a certain suspicion. Despite th...

  • Article
  • Open Access
32 Citations
6,521 Views
11 Pages

Selenoprotein K Increases Efficiency of DHHC6 Catalyzed Protein Palmitoylation by Stabilizing the Acyl-DHHC6 Intermediate

  • Gregory J. Fredericks,
  • FuKun W. Hoffmann,
  • Robert J. Hondal,
  • Sharon Rozovsky,
  • Johann Urschitz and
  • Peter R. Hoffmann

29 December 2017

Selenoprotein K (SELENOK) is a selenocysteine (Sec)-containing protein localized in the endoplasmic reticulum (ER) membrane where it interacts with the DHHC6 (where single letter symbols represent Asp-His-His-Cys amino acids) enzyme to promote protei...

  • Review
  • Open Access
121 Citations
18,131 Views
17 Pages

25 December 2017

Vitamin E is one of the 13 vitamins that are essential to animals that do not produce them. To date, six natural organic compounds belonging to the chemical family of tocochromanols—four tocopherols and two tocotrienols—have been demonstrated as exhi...

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Antioxidants - ISSN 2076-3921