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Antioxidants, Volume 13, Issue 5

May 2024 - 119 articles

Cover Story: C. albicans Prn1 is a protein that is similar to mammalian Pirin, which increases in response to H2O2, a compound used to mimic the oxidative action of phagocytes. To analyse the function of Prn1 in response to oxidative stress, the deleted mutant strain prn1∆ and the wild-type strain SN250 were treated with H2O2. Proteomics studies showed important differences in proteins with oxidoreductase activity, proteasome-related proteins, and several important transcription factors, such as Mnl1. Functional studies validated the results of proteomics studies and showed that the absence of Prn1 led to higher ROS levels, decreased survival, increased apoptosis, and increased proteasome activity. Results support the important role of Prn1 under oxidative stress and its possible role as a target for new antifungals. View this paper
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Articles (119)

  • Article
  • Open Access
11 Citations
2,165 Views
20 Pages

Metabolomic Profiling of Floccularia luteovirens from Different Geographical Regions Proposes a Novel Perspective on Their Antioxidative Activities

  • Chuyu Tang,
  • Yuejun Fan,
  • Tao Wang,
  • Jie Wang,
  • Mengjun Xiao,
  • Min He,
  • Xiyun Chang,
  • Yuling Li and
  • Xiuzhang Li

Floccularia luteovirens, an endemic resource of the Tibetan Plateau, possesses significant medicinal and ecological values. However, the understanding of antioxidant capacity and metabolic profiling of F. luteovirens from diverse regions remains elus...

  • Article
  • Open Access
5 Citations
3,391 Views
22 Pages

Reaction Mechanisms of H2S Oxidation by Naphthoquinones

  • Kenneth R. Olson,
  • Kasey J. Clear,
  • Tsuyoshi Takata,
  • Yan Gao,
  • Zhilin Ma,
  • Ella Pfaff,
  • Anthony Travlos,
  • Jennifer Luu,
  • Katherine Wilson and
  • Zachary Joseph
  • + 7 authors

1,4-naphthoquinones (NQs) catalytically oxidize H2S to per- and polysufides and sulfoxides, reduce oxygen to superoxide and hydrogen peroxide, and can form NQ-SH adducts through Michael addition. Here, we measured oxygen consumption and used sulfur-s...

  • Article
  • Open Access
7 Citations
2,930 Views
16 Pages

Alginate Oligosaccharides Protect Gastric Epithelial Cells against Oxidative Stress Damage through Induction of the Nrf2 Pathway

  • Samantha Acevedo,
  • Alejandra A. Covarrubias,
  • Paola Haeger,
  • Floria Pancetti,
  • Fadia Tala and
  • Erwin de la Fuente-Ortega

Gastric diseases represent a significant global public health challenge, characterized by molecular dysregulation in redox homeostasis and heightened oxidative stress. Although prior preclinical studies have demonstrated the cytoprotective antioxidan...

  • Review
  • Open Access
5 Citations
4,540 Views
18 Pages

Review of the Potential Role of Ascorbate in the Prevention and Treatment of Gynecological Cancers

  • Xiaochang Shen,
  • Jiandong Wang,
  • Boer Deng,
  • Ziyi Zhao,
  • Shuning Chen,
  • Weimin Kong,
  • Chunxiao Zhou and
  • Victoria Bae-Jump

Ascorbate (vitamin C) is an essential vitamin for the human body and participates in various physiological processes as an important coenzyme and antioxidant. Furthermore, the role of ascorbate in the prevention and treatment of cancer including gyne...

  • Article
  • Open Access
4 Citations
2,489 Views
16 Pages

Lutein and Zeaxanthin Enhance, Whereas Oxidation, Fructosylation, and Low pH Damage High-Density Lipoprotein Biological Functionality

  • Jingyuan Zheng,
  • Brian V. Hong,
  • Joanne K. Agus,
  • Xinyu Tang,
  • Nola R. Klebaner,
  • Siyu Chen,
  • Fei Guo,
  • Danielle J. Harvey,
  • Carlito B. Lebrilla and
  • Angela M. Zivkovic

High-density lipoproteins (HDLs) are key regulators of cellular cholesterol homeostasis but are functionally altered in many chronic diseases. The factors that cause HDL functional loss in chronic disease are not fully understood. It is also unknown...

  • Article
  • Open Access
5 Citations
2,291 Views
13 Pages

Ultrasound (US)-assisted soaking combined with fortification with red grape skin (GS) phenolics was applied on two Phaseolus varieties, namely White Kidney Bean (WKB) and Cranberry Bean (CB), before heat treatment. The aims were to investigate: (a) t...

  • Article
  • Open Access
7 Citations
2,675 Views
27 Pages

Ketosis, especially its subclinical form, is frequently observed in high-yielding dairy cows and is linked to various diseases during the transition period. Although adipose tissue plays a significant role in the development of metabolic disorders, i...

  • Article
  • Open Access
14 Citations
6,767 Views
21 Pages

The Mitochondrial-Derived Peptide MOTS-c Alleviates Radiation Pneumonitis via an Nrf2-Dependent Mechanism

  • Yanli Zhang,
  • Jianfeng Huang,
  • Yaru Zhang,
  • Fengjuan Jiang,
  • Shengpeng Li,
  • Shuai He,
  • Jiaojiao Sun,
  • Dan Chen,
  • Ying Tong and
  • Qingfeng Pang
  • + 1 author

Radiation pneumonitis (RP) is a prevalent and fatal complication of thoracic radiotherapy due to the lack of effective treatment options. RP primarily arises from mitochondrial injury in lung epithelial cells. The mitochondrial-derived peptide MOTS-c...

  • Article
  • Open Access
10 Citations
2,338 Views
27 Pages

Examining the Alterations in Metabolite Constituents and Antioxidant Properties in Mountain-Cultivated Ginseng (Panax ginseng C.A. Meyer) Organs during a Two-Month Maturation Period

  • Hee Yul Lee,
  • Du Yong Cho,
  • Du Hyun Kim,
  • Jong-Hwan Park,
  • Jong Bin Jeong,
  • Se Hyeon Jeon,
  • Ji Ho Lee,
  • Eun Jeong Ko,
  • Kye Man Cho and
  • Jin Hwan Lee

The current research was the first to prove the existence of fluctuations in the metabolite constituents and antioxidant properties in different organs (leaves, stems, and roots) of the mountain-cultivated ginseng (MCG) plant during a two-month matur...

  • Article
  • Open Access
6 Citations
2,515 Views
20 Pages

The Effects of Resveratrol and Apigenin on Jejunal Oxidative Injury in Ducks and on Immortalized Duck Intestinal Epithelial Cells Exposed to H2O2

  • Ning Zhou,
  • Yongqing Cao,
  • Youwen Luo,
  • Lihua Wang,
  • Ruiqing Li,
  • Heshuang Di,
  • Tiantian Gu,
  • Yun Cao,
  • Tao Zeng and
  • Jianping Zhu
  • + 6 authors

Oxidative stress increases the apoptosis of intestinal epithelial cells and impairs intestinal epithelial cell renewal, which further promotes intestinal barrier dysfunction and even death. Extensive evidence supports that resveratrol and apigenin ha...

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Antioxidants - ISSN 2076-3921