Search Results (35,124)

Background: In the context of global population aging, nutritional risk has emerged as an important factor associated with both physical and mental health among older adults. This study aimed to examine the associations between nutritional risk, depression, and cognitive function in older adults and to explore potential variations across residential area, educational attainment, employment status, frailty status, and activities of daily living (ADL). Methods: Data were obtained from 9955 community-dwelling older adults aged 65 years and older who participated in the 2023 National Survey of Older Koreans. Nutritional risk was assessed using the DETERMINE checklist (21-point scale), a multidimensional screening tool reflecting dietary, functional, and social risk factors. Depression was measured using the Short-form Geriatric Depression Scale (15-point scale), and cognitive function was assessed using the Korean version of the Mini-Mental State Examination-2 (K-MMSE-2; 30-point scale). Hierarchical multiple linear regression, correlation, subgroup, and sensitivity analyses were conducted, adjusting for sociodemographic characteristics, health behaviors, and geriatric factors. Results: Correlation analyses showed significant associations between nutritional risk and cognitive function (r = −0.191, p < 0.05), nutritional risk and depression (r = 0.440, p < 0.05), and depression and cognitive function (r = −0.259, p < 0.05). Higher nutritional risk scores were significantly associated with greater depressive symptoms (B = 0.314, p < 0.001) and lower cognitive function (B = −0.051, p < 0.05). While some subgroup differences were observed, not all interaction effects reached statistical significance, and these findings should be interpreted with caution. Conclusions: These findings suggest that nutritional risk is associated with depressive symptoms and cognitive function in older adults. Given that the DETERMINE checklist reflects multidimensional vulnerability, the results should be interpreted as indicating broader risk contexts rather than direct nutritional status alone. These findings highlight the importance of integrated, multidimensional approaches to support older adults at nutritional risk in community settings. Full article

The link between neurodevelopment in infants exposed to maternal gestational diabetes mellitus (GDM) and fetal DNA methylation remains unexplored. We conducted this hypothesis-generating study to investigate the association between fetal DNA methylation and neurodevelopmental outcomes in children of mothers with GDM. We carried out a prospective, observational pilot cohort study comparing infants exposed to maternal GDM with an unexposed control group. Umbilical cord blood DNA methylation was assessed using targeted methylome sequencing covering 3.34 million CpG sites. Infant neurodevelopment was evaluated at age two years using the Bayley-III Scales. Bioinformatics processing identified differentially methylated regions (DMRs), followed by multiple enrichment analyses of DMR-associated genes and partial correlation analyses. Multi-dimensional enrichment analysis of the 1053 identified DMR-associated genes revealed a significant convergence of pathways related to neurogenesis, synaptic components, and axonal guidance. Infants born to mothers with GDM exhibited lower scores in cognitive, language, and motor domains, which were associated with identifiable DNA methylation signatures at birth. Significant correlations were observed in genes essential for brain scaffolding and synaptic circuitry, most notably WNT4, the PCDHG alpha/beta clusters, and PALM. Additionally, methylation patterns in FOXF2 and CHFR suggest a potential impact on blood–brain barrier integrity, while associations with FSTL3 and H6PD highlight a systemic metabolic ‘cross-talk’ influencing neurodevelopment. Although these pilot findings are hypothesis-generating and require further functional validation, this study provides pioneering evidence that neurodevelopmental alterations in the offspring of mothers with GDM are potentially associated with intrauterine epigenetic modifications detectable at birth. Full article

Functional pet food has grown rapidly, in line with the accelerated humanization of pets, growing attention to relations between diet and health, and mounting sustainability awareness. The article provides a critical overview of recent developments and new trends in functional pet food, combining data from published works, patents and market-driven innovative companies. The current trends depict a transition from single-nutrient fortification to integrated nutrition interventions through modulation of gastrointestinal health, immunity, metabolism, cognition and age-associated conditions. Special attention is dedicated to probiotics, prebiotics, postbiotics, polyphenols and novel protein sources, as well as innovations in processing and delivery technologies. The review highlights ongoing issues on the relevance of study design, available long-term safety information and our capacity to mechanistically underpin claims with respect to function. Because this review maps clusters of innovation and clusters of underdeveloped knowledge, it offers a roadmap for the translational pathway from scientific discovery to commercialization. The results highlight a call for harmonized methods, longer duration studies and integrative omics-based approaches in order to improve the evidence basis formulation and responsible marketing of future functional pet food products following credible, safe and sustainable strategies. Full article

Background/Objectives: The use of personal smartphones by healthcare professionals in clinical settings has become a growing area of concern as practice may not consistently align with policy guidance. This study enhances our understanding of how and why medical residents are using smartphones to communicate patient healthcare information with other physicians in daily practice and provides insights into the role that institutional governance, policies, and structures play in the use of smartphones. Methods: This study used qualitative techniques to examine medical residents’ use of smartphones to communicate healthcare-related information with colleagues. Additionally, a neo-institutional theory lens was applied to assess the role that regulative (guidelines/policies), normative (what peers/staff are doing), and cultural-cognitive (beliefs/perceptions) factors play in smartphone use by medical residents. Results: The results suggest that behaviour related to smartphone use is based primarily on normative and cultural-cognitive factors rather than regulative factors. Regulative elements around smartphone use play a smaller role in shaping behaviour, particularly when they: (1) lack clarity; (2) are not seen as credible/legitimate; or (3) are viewed as cumbersome and do not align with workflow needs. Conclusions: The implementation of future guidelines/policies should consider the use of mentorships throughout postgraduate medical training whereby staff physicians educate, model, and promote behaviour in accordance with the associated policies/guidelines. Full article

Process-based cognitive behavioral therapy (PB-CBT) seeks to identify kernels that are equally efficacious in treating various disorders. While both metacognitive therapy (MCT) and acceptance and commitment therapy (ACT) represent evidence-based interventions for generalized anxiety disorder (GAD), it remains unclear if there are specific components within each that are comparable in managing meta-worrying characteristic of GAD. A subclinical sample of college students received a brief session targeting a single, personally relevant meta-worry of either metacognitive restructuring as practiced in MCT or an extension of ACT defusion exercises. Both were equally effective in impacting believability, distress, and willingness ratings of the targeted worry as well as untargeted worries. However, significantly longer metacognitive defusion sessions suggest that metacognitive restructuring may represent a more cost-effective option. Levels of generalized anxiety, dispositional worrying, and depression did not moderate treatment responsivity. Implications of findings for PB-CBT research and practice are discussed within the context of study limitations. Full article

Background/Objectives: Mild cognitive impairment (MCI), the prodromal stage of Alzheimer’s disease, may be influenced by nutritional status and genetic susceptibility. This systematic review synthesised evidence on how nutritional biomarkers interact with genetic variants, particularly APOE ε4, to influence cognitive outcomes in individuals with MCI. Methods: Following PRISMA 2020 guidelines, seven studies were included (three longitudinal, two randomised controlled trials, and two cross-sectional) involving adults aged ≥55 years with MCI. Nutritional exposures comprised plasma or serum concentrations of vitamins A, D, E, the vitamin B group, lipids, selenium, and ketogenic medium-chain triglycerides. Genetic risk was assessed primarily through APOE ε4 status. Risk of bias was assessed using RoB 2 and ROBINS-I, and certainty of evidence using GRADE. Due to heterogeneity in biomarkers, cognitive tools, and study designs, findings were synthesised narratively. Results: Across nutrient categories, higher concentrations of vitamin D, selenium, and antioxidants were associated with better cognitive outcomes. kMCT supplementation improved episodic memory and brain energy metabolism. Evidence for nutrient–gene interactions was mixed: APOE ε4 modified responses to vitamin B group and selenium but showed limited influence on vitamin D, lipids, or kMCT effects. Heterogeneity in biomarker assays, cognitive tools, and genetic stratification limited comparability across studies. Conclusions: Nutritional biomarkers appear to influence cognitive trajectories in MCI, and some associations may differ by APOE ε4 status. However, small samples and limited genetic stratification constrain interpretation. Future research should prioritise standardised biomarker measurement, genetically stratified cohorts, and individual participant data meta-analyses to clarify nutrient–gene interactions in MCI. Full article

Driven by global sustainable development and intelligent technological innovation, the geotechnical engineering industry is transforming toward the direction of “Intelligent technology + Low-carbon circulation + Ecological friendliness”, creating an urgent demand for interdisciplinary talents with corresponding professional capabilities and sustainable awareness. To address the deficiencies in traditional postgraduate education (e.g., disjointed knowledge systems, inadequate practice oriented to Sustainable Geotechnical Engineering (SGE), and superficial integration of Education for Sustainable Development (ESD), this study constructs a “Four-Dimensional and Four-Stage” integrated talent training model based on the Sustainable Development Goals (SDGs) of the United Nations. Taking “Intelligent Technology—Geotechnical Theory—SGE Scenarios—ESD Literacy” as its core framework and adopting a progressive path of “Basic Cognition—Collaborative Application—Innovative Development—Sustainable Transformation”, this model was piloted among 23 postgraduate students through the course titled “Intelligent Design and Construction of Geotechnical Engineering”. The results show that all the students obtained officially granted software copyrights, their core professional capabilities were significantly improved, 100% of them applied their research achievements to SGE-related practices, and their ESD literacy was notably enhanced. Breaking through the traditional “knowledge-practice” dualistic framework of engineering education, this model achieves the in-depth integration of professional training and sustainable awareness cultivation and thus provides a replicable paradigm for the ESD education of interdisciplinary postgraduate students in the intelligent age. Full article

This study examines the impact of explainable artificial intelligence (XAI) features on user satisfaction and purchase intention in Saudi mobile shopping applications, utilising the stimulus–organism–response (S–O–R) framework. With the increasing reliance on AI-driven decision support in e-commerce, enhancing transparency, fairness, trustworthiness, and interpretability has become crucial for shaping consumer perceptions and behavioural responses. The research employed a quantitative methodology using partial least squares structural equation modelling (PLS-SEM) to examine the relationships among stimulus factors, cognitive and affective states, consumer satisfaction, and purchase intention. In a survey of 597 respondents from Jeddah and Makkah, Saudi Arabia, the findings highlight that fairness and bias detection, trustworthiness, and transparency significantly influence consumers’ cognitive and affective states, which in turn enhance satisfaction and intention to purchase. Consumer satisfaction emerged as a critical mediator, reinforcing the role of positive emotional and cognitive experiences in driving purchase behaviours. However, interpretability showed limited impact, suggesting that consumers may prioritise fairness and trustworthiness over technical clarity of explanations. Theoretically, this study contributes to advancing knowledge on the role of XAI in consumer behaviour by integrating fairness, transparency, and affective responses into the S–O–R paradigm. From a managerial perspective, the results underscore the importance for mobile shopping platforms to design AI systems that foster trust, reduce perceived bias, and ensure transparency, thereby improving consumer engagement and purchase outcomes. By addressing gaps in interpretability and transparency, businesses can strengthen user trust and loyalty, ultimately enhancing competitive advantage in Saudi Arabia’s rapidly growing e-commerce sector. Full article

The widespread adoption of generative artificial intelligence in higher education has intensified debates around assessment, authorship, and academic integrity. This paper argues that such debates obscure a more fundamental pedagogical shift, namely, the decoupling of assessment performance from cognitive engagement. Historically, assessment functioned not only as a measure of learning, but also as a structural mechanism that implicitly enforced cognitive engagement. With the advent of GenAI, learners can increasingly produce assessment outputs without necessarily engaging in the cognitive processes traditionally associated with learning. As a result, cognitive engagement has shifted from being a pedagogical necessity to an intentional learner choice. This paper conceptualises this shift as the cognitive engagement gap, wherein successful assessment completion no longer reliably indicates learning or epistemic development. Through a theory-informed conceptual analysis, the paper examines how GenAI reconfigures learning processes, challenges the validity of assessment as a proxy for learning, and exposes long-standing assumptions embedded in assessment-centred pedagogies. In response, the paper proposes a Cognitive Engagement-Centred Assessment (CECA) framework, offering principled guidance for designing assessment that foregrounds cognitive processes, metacognition, and learning assurance in AI-mediated environments. The paper concludes by positioning GenAI not as a threat to assessment, but as a catalyst for more intentional, transparent, and learning-centred pedagogical design. Full article

Organizations are increasingly required to promote a culture of sustainability among their employees. Accordingly, a growing number of organizations have implemented work practices centered on pro-environmental behaviors. However, the psychological mechanisms underlying these behaviors in the workplace remain insufficiently explored. Grounded in Social Cognitive Theory and normative frameworks, the present study proposes a moderated mediation model examining the relationship between collective efficacy and employees’ pro-environmental behaviors, the mediating role of personal norm, and the moderating role of injunctive norm. Data were collected from 906 Italian employees who completed an online questionnaire, and the hypothesized model was tested using moderated mediation analyses. The results showed that collective efficacy was positively associated with personal norm, which in turn was positively related to pro-environmental behaviors, indicating an indirect association pattern consistent with the hypothesized mediating role of personal norm. Moreover, injunctive norm strengthened the relationship between collective efficacy and pro-environmental behaviors. These findings highlight the central role of moral obligation in translating collective beliefs into sustainable action and underscore the importance of normative organizational climates. This study contributes to the organizational sustainability literature by integrating collective efficacy and normative processes as key drivers of everyday pro-environmental behavior at work. Full article

Background/Objective: A substantial proportion of patients with obsessive–compulsive disorder (OCD) does not respond adequately to first-line treatments such as selective serotonin reuptake inhibitors and cognitive-behavioral therapy. OCD has traditionally been conceptualized as a serotonergic disorder. However, emerging evidence suggests that glutamatergic dysfunction plays an important role. Ketamine and esketamine are NMDA receptor antagonists with rapid antidepressant effects and have therefore attracted interest as potential treatments for OCD. This scoping review aims to map and synthesize the existing preclinical and clinical evidence regarding the therapeutic potential of ketamine and esketamine in OCD. Methods: A scoping review methodology based on the Arksey and O’Malley framework and Joanna Briggs Institute guidance was applied. Searches were conducted in PubMed, Scopus, and Web of Science. Studies that examined ketamine or esketamine in OCD populations or relevant experimental models were included. Results: Twenty-one studies met the inclusion criteria, of which five were preclinical studies and sixteen were clinical investigations. Preclinical evidence suggests that ketamine and esketamine improve compulsive-like behaviors. Clinical studies suggest that ketamine can produce rapid reductions in obsessive symptoms, though results remain inconsistent. Most trials evaluated single administrations, while limited evidence suggests that repeated dosing strategies may provide greater clinical benefit. Conclusions: Ketamine and esketamine show promise as rapid acting interventions for OCD, particularly in treatment refractory cases. However, current evidence remains preliminary and heterogeneous. Future research should prioritize adequately powered randomized trials and investigation of repeated administration protocols with longer follow-up periods to determine efficacy and optimal clinical implementation. Full article

Neuroinflammation mediated by astrocyte–microglia interactions plays a critical role in the progression of neurodegenerative disorders. Celastrus paniculatus (CP) seeds have long been associated with cognitive benefits; however, the chemical composition and anti-inflammatory potential of their high-polarity fractions remain poorly characterized. In this study, thin-layer chromatography (TLC)-derived high-polarity fractions (F6 and F7) from CP seeds were analyzed using untargeted LC–MS/MS metabolite profiling. After quality filtering, 99 metabolites were retained for classification, with enrichment of alkaloids and terpenoid-related compounds, including 41 structurally complex metabolites. To evaluate biological relevance, BV2 microglia were exposed to astrocyte-conditioned medium derived from H₂O₂-treated astrocytes (ACM-H), modeling sterile inflammatory signaling. ACM-H stimulation induced microglial activation characterized by morphological transformation, increased CD40 and inducible nitric oxide synthase (iNOS) expression, and elevated production of pro-inflammatory cytokines TNF-α and IL-6. Co-treatment with CP fractions attenuated ACM-H-induced inflammatory responses, with fraction F7 showing stronger effects than F6. Fraction F7 showed stronger inhibitory effects on CD40 and iNOS expression, suppressed TNF-α and IL-6 production, and partially restored ramified microglial morphology, whereas F6 exhibited comparable anti-inflammatory activity and showed a stronger effect on microglial phagocytic responses. Metabolomic analysis further indicated a higher relative abundance of terpenoid-related metabolites in F7. Collectively, these findings indicate that CP seed fractions, particularly F7, attenuate astrocyte-driven microglial activation in an in vitro sterile neuroinflammatory model. Full article

Background: Dermatological conditions represent a leading cause of global nonfatal disease burden, accounting for approximately 42.9 million disability-adjusted life years annually. Their complex pathogenesis is increasingly understood through the skin–brain–exposome axis, a bidirectional neuroimmunological and environmental communication network. The study aims to synthesize the neurobiological mechanisms of the skin–brain–exposome axis with macroscopic sociodemographic modifiers, clinical manifestations, and evidence-based psychodermatological interventions. Methods: A narrative review was conducted, following a structured search of PubMed, Scopus, and Web of Science (from inception to February 2026), yielding 54 sources. Mechanistic and interventional data (including randomized controlled trials and meta-analyses) were integrated with large-scale population-based epidemiological findings, anchored by a recent cross-sectional Polish cohort of 27,000 adults. Results: Psychological distress is associated with hyperactivation of the hypothalamic–pituitary–adrenal (HPA) axis and peripheral neurogenic inflammation (e.g., Substance P, corticotropin-releasing hormone), exacerbating stress-sensitive conditions such as atopic dermatitis, psoriasis, acne, and chronic pruritus. External exposome factors (urbanization, pollution) and sociodemographic variables (education, gender) may modify biological risk and diagnostic capture rates, frequently generating an epidemiological diagnostic paradox. Randomized trials support that psychotherapeutic interventions, particularly Cognitive Behavioral Therapy (CBT) and Mindfulness-Based Stress Reduction (MBSR), effectively disrupt the physical itch–scratch–stress cycle and improve disease-specific quality of life, serving as evidence-based adjunctive strategies in comprehensive care. Conclusions: Effective dermatological management requires targeting both the cutaneous barrier and the psychological exposome. Integrating routine psychosocial screening and stratified behavioral interventions into standard clinical care is essential for addressing the neuroimmune chronicity of inflammatory skin diseases. Full article

Acute liver failure is often accompanied by neurological disturbances collectively referred to as hepatic encephalopathy (HE), characterized by neuroinflammation and subsequent cognitive decline. Insulin-like growth factor 1 (IGF1) is a neuroprotective peptide with anti-inflammatory properties in the brain. The role of IGF1 in cognitive deficits and neuroinflammation during HE remains largely unexplored. In C57Bl/6 mice, HE was established through an intraperitoneal injection of azoxymethane (AOM), and tissues were collected at defined time points during disease development. IGF1 expression in the cortex was downregulated following AOM administration. Central infusion of recombinant mouse IGF1 (rmIGF1) before AOM injection resulted in delayed neurological impairment, reduced microglial activation, and decreased proinflammatory cytokine and chemokine production in AOM mice. In vitro, rmIGF1 and conditioned media derived from rmIGF1-treated primary neurons attenuated phagocytic activity and C–C motif chemokine ligand 2 (CCL2) production in the microglial cell line EOC-20. Collectively, our results show that IGF1, whose levels decline during HE, alleviates neuroinflammation and improves the pathological state of AOM-treated mice through the suppression of microglial activation and the regulation of neuron–microglia paracrine communication. Full article

With the growing simultaneous demands for miniaturization and high performance, thermal issues such as hotspots severely degrade the high-speed signal transmission performance of low temperature co-fired ceramic (LTCC) substrate in system-in-package (SiP) modules. This paper proposes a high-speed transmission line design for LTCC substrates, using a G-S (Ground-Signal) structure to ensure reliable signal transmission quality. Based on this structure, finite element simulations are performed to investigate the electromagnetic signal transmission characteristics under both uniform and non-uniform thermal fields, confirming that signal transmission efficiency exhibits strong temperature dependence. The results indicate that when the temperature exceeds 50 °C, non-uniform temperature distributions exert a significantly stronger influence on electromagnetic performance, leading to aggravated signal reflections and reduced transmission efficiency. At 300 °C, the transmission efficiency under non-uniform temperature drops to 35.0%, which is a 61.8% decrease compared with the optimal scheme obtained under ideal electric field conditions. Under electromagnetic-thermal coupling, a comparative study of different schemes shows that the optimal design derived from a single electric field is not suitable for electromagnetic-thermal coupled working conditions. The optimized Scheme 2 increases transmission efficiency to about 75.3%, with smoother S-parameter curves and smaller fluctuations. These findings provide valuable references for subsequent reliability-oriented design and experimental verification. Full article