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Brain Sciences, Volume 14, Issue 3

March 2024 - 109 articles

Cover Story: Neurofilament light chain (NfL) measurement in biological fluids has a promising role in the diagnosis, prognosis, and monitoring of the therapeutic response in neurological diseases, including neurodegenerative dementias. In recent years, its relationship with clinical phenotypes and measures of disease severity has been extensively studied. Here, we reviewed studies investigating the association between NfLs and imaging measures of gray matter (GM) and white matter (WM) damage in neurodegenerative dementias. We identified a large number of studies investigating this association in Alzheimer’s disease (AD) and the spectrum of disorders of frontotemporal dementia (FTD). Results were heterogeneous, possibly due to different methodological approaches—both in NfL measurements and imaging analyses—and inclusion criteria. View this paper
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Articles (109)

  • Article
  • Open Access
1 Citations
2,181 Views
10 Pages

Cerebrospinal Fluid Dynamics and Partial Pressure of Carbon Dioxide as Prognostic Indicators in Hypoxic–Ischemic Brain Injury Following Cardiac Arrest

  • So Young Jeon,
  • Hong Joon Ahn,
  • Changshin Kang,
  • Yeonho You,
  • Jung Soo Park,
  • Jin Hong Min,
  • Wonjoon Jeong and
  • Yong Nam In

Changes in cerebrospinal fluid (CSF) dynamics can have adverse effects on neuronal function. We hypothesized that patients with hypoxic–ischemic brain injury (HIBI) showing poor neurological outcomes after cardiac arrest (CA) would exhibit chan...

  • Review
  • Open Access
25 Citations
4,261 Views
16 Pages

Clustering Functional Magnetic Resonance Imaging Time Series in Glioblastoma Characterization: A Review of the Evolution, Applications, and Potentials

  • Matteo De Simone,
  • Giorgio Iaconetta,
  • Giuseppina Palermo,
  • Alessandro Fiorindi,
  • Karl Schaller and
  • Lucio De Maria

In this paper, we discuss how the clustering analysis technique can be applied to analyze functional magnetic resonance imaging (fMRI) time-series data in the context of glioblastoma (GBM), a highly heterogeneous brain tumor. The precise characteriza...

  • Brief Report
  • Open Access
3,476 Views
9 Pages

A Retrospective Analysis of Temporal Lobe Gliosis after Middle Fossa Resection of Small Vestibular Schwannomas

  • Matthias Scheich,
  • Miriam Bürklein,
  • Manuel Stöth,
  • Brigitte Bison,
  • Rudolf Hagen,
  • Stephan Hackenberg and
  • Marius L. Vogt

Introduction: The middle cranial fossa (MCF) approach is a well-established procedure in surgery of the internal auditory canal, as well as with the retrosigmoid and translabyrinthine approaches. It is commonly used in the hearing-preserving microsur...

  • Review
  • Open Access
15 Citations
15,946 Views
24 Pages

Alcohol use disorder (AUD) is a significant contributor to morbidity and mortality in the United States. It contributes to over 140,000 annual deaths, to over 200 related diseases and health conditions globally, and accounts for 5.1% of the global di...

  • Article
  • Open Access
8 Citations
3,404 Views
12 Pages

Co-ultraPEALut in Subjective Cognitive Impairment Following SARS-CoV-2 Infection: An Exploratory Retrospective Study

  • Valentina Cenacchi,
  • Giovanni Furlanis,
  • Alina Menichelli,
  • Alberta Lunardelli,
  • Valentina Pesavento and
  • Paolo Manganotti

Neurological involvement following coronavirus disease 19 (COVID-19) is thought to have a neuroinflammatory etiology. Co-ultraPEALut (an anti-inflammatory molecule) and luteolin (an anti-oxidant) have shown promising results as neuroinflammation anta...

  • Case Report
  • Open Access
2 Citations
7,047 Views
20 Pages

Effects of Cervical Spinal Manipulation on Saccadic Eye Movements

  • Adam Klotzek,
  • Monem Jemni,
  • Shad James Groves and
  • Frederick Robert Carrick

Quantifying saccadic eye movements can assist in identifying dysfunctional brain networks in both healthy and diseased people. Infrared Oculography is a simple and non-invasive approach to capturing and quantifying saccades, providing information tha...

  • Systematic Review
  • Open Access
8 Citations
10,536 Views
17 Pages

Auditory Processing and Speech-Sound Disorders

  • Konstantinos Drosos,
  • Alexandra Papanicolaou,
  • Louiza Voniati,
  • Klea Panayidou and
  • Chryssoula Thodi

Background: Speech-sound disorders (SSD) have been linked to auditory processing difficulties, and auditory processing disorders (APD) have been related to phonological awareness and literacy development. To this date, there has not been a systematic...

  • Article
  • Open Access
8 Citations
3,186 Views
16 Pages

Neuroinflammation contributes to the pathophysiology of major depressive disorder (MDD) by inducing neuronal excitability via dysregulation of microglial brain-derived neurotrophic factor (BDNF), Na-K-Cl cotransporter-1 (NKCC1), and K-Cl cotransporte...

  • Article
  • Open Access
6 Citations
1,992 Views
10 Pages

To evaluate the efficacy of perivascular sympathectomy in managing adventitia layer-related long-segment tubular stenosis of cervical segment (C1) internal carotid arteries (ICAs) in a cohort where conventional medical and endovascular interventions...

  • Article
  • Open Access
2,312 Views
10 Pages

The Food Finding Test (FFT) olfactory paradigm without overnight food deprivation examined olfaction in aged (16-months-old) animals. Ethograms of three goal-directed behaviors towards hidden food (sniffing, finding and eating) elicited in male and f...

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Brain Sci. - ISSN 2076-3425