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Brain Sciences, Volume 14, Issue 4

2024 April - 111 articles

Cover Story: Knowledge of the cognitive and motor contributions during learning phases can be helpful in developing effective and targeted interventions for healthy aging. Eighty-six healthy older participants underwent an extensive cognitive, motoric, and musical test battery. Within one session, one piano-related and one music-independent movement sequence were both learned. We tested the associations between skill performance and cognito-motor abilities with Bayesian mixed models accounting for individual learning rates. Results showed that performance was positively associated with all cognito-motor abilities. Learning a piano-related task was characterized by relatively strong initial associations between performance and abilities. These associations then weakened considerably before increasing exponentially from the second trial onwards, approaching a plateau. View this paper
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Articles (111)

  • Article
  • Open Access
2 Citations
2,788 Views
15 Pages

Considering the advantages of brain stimulation techniques in detecting the role of different areas of the brain in human sensorimotor behaviors, we used anodal transcranial direct-current stimulation (a-tDCS) over three different brain sites of the...

  • Article
  • Open Access
4 Citations
3,589 Views
15 Pages

Reliability and Construct Validity of a Mobile Application for the Finger Tapping Test Evaluation in People with Multiple Sclerosis

  • Víctor Navarro-López,
  • Roberto Cano-de-la-Cuerda,
  • Pilar Fernández-González,
  • Selena Marcos-Antón,
  • Aitor Blázquez-Fernández,
  • María Fernández-Cañas and
  • Diego Fernández-Vázquez

The finger tapping test (FTT) is a tool to evaluate the motor performance of the hand and fingers and eye-hand coordination with applicability in people with multiple sclerosis (pwMS). The aim of this study was to evaluate the intra- and inter-rater...

  • Article
  • Open Access
2 Citations
4,979 Views
12 Pages

Deep Learning-Driven Estimation of Centiloid Scales from Amyloid PET Images with 11C-PiB and 18F-Labeled Tracers in Alzheimer’s Disease

  • Tensho Yamao,
  • Kenta Miwa,
  • Yuta Kaneko,
  • Noriyuki Takahashi,
  • Noriaki Miyaji,
  • Koki Hasegawa,
  • Kei Wagatsuma,
  • Yuto Kamitaka,
  • Hiroshi Ito and
  • Hiroshi Matsuda

Background: Standard methods for deriving Centiloid scales from amyloid PET images are time-consuming and require considerable expert knowledge. We aimed to develop a deep learning method of automating Centiloid scale calculations from amyloid PET im...

  • Article
  • Open Access
5 Citations
5,521 Views
17 Pages

What Does It Take to Play the Piano? Cognito-Motor Functions Underlying Motor Learning in Older Adults

  • Florian Worschech,
  • Edoardo Passarotto,
  • Hannah Losch,
  • Takanori Oku,
  • André Lee and
  • Eckart Altenmüller

The acquisition of skills, such as learning to play a musical instrument, involves various phases that make specific demands on the learner. Knowledge of the cognitive and motor contributions during learning phases can be helpful in developing effect...

  • Article
  • Open Access
4 Citations
3,906 Views
15 Pages

Imagery and Verbal Strategies in Spatial Memory for Route and Survey Descriptions

  • Ioanna Markostamou,
  • Sol Morrissey and
  • Michael Hornberger

Being able to represent and remember verbally-encoded information about spatial environments from different perspectives is important for numerous daily activities. The present study examined how frequently individuals spontaneously engage in visual...

  • Article
  • Open Access
1 Citations
3,344 Views
12 Pages

Movement and muscle control are crucial for the survival of all free-living organisms. This study aimed to explore differential patterns of cortical and subcortical activation across different stages of muscle control using functional magnetic resona...

  • Article
  • Open Access
2 Citations
3,092 Views
14 Pages

Sensorimotor Oscillations in Human Infants during an Innate Rhythmic Movement

  • Helene Vitali,
  • Claudio Campus,
  • Valentina De Giorgis,
  • Sabrina Signorini,
  • Federica Morelli,
  • Marco Fasce and
  • Monica Gori

The relationship between cerebral rhythms and early sensorimotor development is not clear. In recent decades, evidence revealed a rhythmic modulation involving sensorimotor processing. A widely corroborated functional role of oscillatory activity is...

  • Article
  • Open Access
3 Citations
3,131 Views
13 Pages

The morphology of the brain undergoes changes throughout the aging process, and accurately predicting a person’s brain age and gender using brain morphology features can aid in detecting atypical brain patterns. Neuroimaging-based estimation of...

  • Article
  • Open Access
3 Citations
2,902 Views
13 Pages

This study employs event-related potential (ERP) to examine the impact of empathic concern on prosocial decision-making with costs in both gain and loss contexts. In this experiment, participants can choose between two types of lottery tickets and pa...

  • Article
  • Open Access
19 Citations
3,893 Views
21 Pages

Acupuncture Extended the Thrombolysis Window by Suppressing Blood–Brain Barrier Disruption and Regulating Autophagy–Apoptosis Balance after Ischemic Stroke

  • Zhihui Zhang,
  • Tianliang Lu,
  • Shanshan Li,
  • Ruyu Zhao,
  • Honglei Li,
  • Xinchang Zhang,
  • Yiyang Li,
  • Yawen Xia and
  • Guangxia Ni

Background: Ischemic stroke (IS) is one of the leading causes of death and disability worldwide. The narrow therapeutic window (within 4.5 h) and severe hemorrhagic potential limits therapeutic efficacy of recombinant tissue type plasminogen activato...

  • Article
  • Open Access
2 Citations
2,226 Views
13 Pages

Cerebral and Peripheral Immune Cell Changes following Rodent Juvenile Traumatic Brain Injury

  • Allie M. Smith,
  • Erin B. Taylor,
  • Ruth J. Brooks,
  • Christiano Dos Santos e Santos and
  • Bernadette E. Grayson

Traumatic brain injury (TBI) is one of the leading causes of death and disability. TBI is associated with neuroinflammation, but temporal changes in immune and inflammatory signaling following TBI have not been fully elucidated. Furthermore, there ha...

  • Article
  • Open Access
16 Citations
3,567 Views
16 Pages

The Impact of Fatigue on Sleep and Other Non-Motor Symptoms in Parkinson’s Disease

  • Stefania Diaconu,
  • Vlad Monescu,
  • Rafaela Filip,
  • Laura Marian,
  • Cristian Kakucs,
  • Iulia Murasan,
  • K. Ray Chaudhuri,
  • Dragos Catalin Jianu,
  • Cristian Falup-Pecurariu and
  • Bianca Opritoiu

Fatigue is a common non-motor symptom in Parkinson’s disease (PD), but even so, it may still be underdiagnosed or misdiagnosed in current practice due to its non-specific manifestations. The aims of this study were to investigate the prevalence...

  • Article
  • Open Access
1 Citations
1,999 Views
19 Pages

In the past few years, significant advancements in microscopic imaging technology have led to the production of numerous high-resolution images capturing brain neurons at the micrometer scale. The reconstructed structure of neurons from neuronal imag...

  • Systematic Review
  • Open Access
8 Citations
7,677 Views
16 Pages

The present meta-analysis summarizes brain activation for social cognition and emotion-processing tasks in borderline personality disorder (BPD). We carried out two meta-analyses to elaborate on commonalities and potential differences between the two...

  • Article
  • Open Access
7 Citations
2,870 Views
9 Pages

Racial and Socioeconomic Status among a Patient Population Presenting with Aneurysmal Subarachnoid Hemorrhage versus Unruptured Intracranial Aneurysm: A Single-Center Study

  • Ashia M. Hackett,
  • Christopher O. Adereti,
  • Ariel P. Walker,
  • Elsa Nico,
  • Lea Scherschinski,
  • Emmajane G. Rhodenhiser,
  • Adam T. Eberle,
  • Anant Naik,
  • Juan P. Giraldo and
  • Michael T. Lawton
  • + 4 authors

Racial and socioeconomic health disparities are well documented in the literature. This study examined patient demographics, including socioeconomic status (SES), among individuals presenting with aneurysmal subarachnoid hemorrhage (aSAH) and unruptu...

  • Article
  • Open Access
7 Citations
4,404 Views
9 Pages

Objectives: To study sociodemographic and clinical variables, including psychiatric co-morbidities, in patients with irritable bowel syndrome. Methods: A total of 158 patients attending a medical gastroenterology clinic in a tertiary care center in N...

  • Review
  • Open Access
9 Citations
7,062 Views
24 Pages

Decades of research has revealed a relationship between childhood socioeconomic status (SES) and brain development at the structural and functional levels. Of particular note is the distinction between income and maternal education, two highly correl...

  • Article
  • Open Access
12 Citations
3,436 Views
16 Pages

Home-Based Transcranial Direct Current Stimulation in Primary Progressive Aphasia: A Pilot Study

  • Kyriaki Neophytou,
  • Kelly Williamson,
  • Olivia Herrmann,
  • Alexandros Afthinos,
  • Jessica Gallegos,
  • Nadine Martin,
  • Donna C. Tippett and
  • Kyrana Tsapkini

Background: This study aims to determine (a) if home-based anodal transcranial direct current stimulation (a-tDCS) delivered to the left supramarginal gyrus (SMG) coupled with verbal short-term memory/working memory (vSTM/WM) treatment (“RAM&rd...

  • Article
  • Open Access
6 Citations
2,507 Views
21 Pages

Our study examined the complex relationships among reading performance (decoding, comprehension) and language, visuo-spatial, and attentional control abilities in 115 Italian-speaking children. Latent profile analysis was used to identify distinct cl...

  • Article
  • Open Access
8 Citations
2,923 Views
15 Pages

A Four-Week High-Fat Diet Induces Anxiolytic-like Behaviors through Mature BDNF in the mPFC of Mice

  • Huixian Huang,
  • Jia Huang,
  • Wensi Lu,
  • Yanjun Huang,
  • Ran Luo,
  • Luqman Bathalian,
  • Ming Chen and
  • Xuemin Wang

The effect of a high-fat diet (HFD) on mood is a widely debated topic, with the underlying mechanisms being poorly understood. This study explores the anxiolytic effects of a four-week HFD in C57BL/6 mice. Five-week-old mice were exposed to either an...

  • Article
  • Open Access
1 Citations
3,203 Views
21 Pages

A screening questionnaire for autism symptoms is not yet available in Poland, and there are no recommendations regarding screening for developmental disorders in Polish primary healthcare. The aim of this study was to assess the opinions of parents a...

  • Article
  • Open Access
2 Citations
2,811 Views
14 Pages

Pragmatic Communication Deficit and Functional Outcome in Patients with Right- and Left-Brain Damage: A Pilot Study

  • Simona Spaccavento,
  • Sofia Caliendo,
  • Roberta Galetta,
  • Emilia Picciola,
  • Ernesto Losavio and
  • Robert Glueckauf

Pragmatic communication abilities refer to the capacity to use language in a social context. Despite evidence to the contrary, the left cerebral hemisphere of the majority of right handers has been considered exclusively specialized for control of la...

  • Review
  • Open Access
17 Citations
11,270 Views
24 Pages

An Overview of the Bodily Awareness Representation and Interoception: Insights and Progress in the Field of Neurorehabilitation Research

  • Chiara Parma,
  • Federica Doria,
  • Aida Zulueta,
  • Jacopo Lanzone,
  • Marilisa Boscarino,
  • Luca Giani,
  • Christian Lunetta,
  • Marta Vassallo,
  • Eugenio Agostino Parati and
  • Davide Sattin
  • + 1 author

In the last two decades, the scientific literature on so-called body representations has been increasing, and the notion of body awareness (BA) is particularly interesting for neurorehabilitation. In this article, we present results derived from rece...

  • Review
  • Open Access
2 Citations
7,622 Views
10 Pages

Recent studies highlight how body psychotherapy is becoming highly cited, especially in connection with studies on trauma-related disorders. This review highlights the theoretical assumptions and recent points in common with embodied simulation and n...

  • Article
  • Open Access
5 Citations
3,341 Views
11 Pages

Multiple sclerosis (MS) is one of the chronic and neurodegenerative diseases of the central nervous system (CNS). It generally affects motor, sensory, cerebellar, cognitive, and language functions. It is thought that identifying MS speech disorders u...

  • Review
  • Open Access
12 Citations
9,616 Views
18 Pages

AI and Aphasia in the Digital Age: A Critical Review

  • Adam John Privitera,
  • Siew Hiang Sally Ng,
  • Anthony Pak-Hin Kong and
  • Brendan Stuart Weekes

Aphasiology has a long and rich tradition of contributing to understanding how culture, language, and social environment contribute to brain development and function. Recent breakthroughs in AI can transform the role of aphasiology in the digital age...

  • Article
  • Open Access
5 Citations
2,149 Views
26 Pages

This paper presents a novel approach to improving the detection of mild cognitive impairment (MCI) through the use of super-resolved structural magnetic resonance imaging (MRI) and optimized deep learning models. The study introduces enhancements to...

  • Article
  • Open Access
4 Citations
4,043 Views
12 Pages

To determine the critical timing for learning and the associated synaptic plasticity, we analyzed developmental changes in learning together with training-induced plasticity. Rats were subjected to an inhibitory avoidance (IA) task prior to weaning....

  • Article
  • Open Access
4 Citations
2,540 Views
14 Pages

The analgesic efficacy of acupuncture has been widely recognized. However, the mechanism by which manual acupuncture-generated mechanical stimuli translate into biological signals remains unclear. This study employed a CFA-induced inflammatory pain r...

  • Systematic Review
  • Open Access
21 Citations
12,866 Views
26 Pages

Prevalence and Correlates of the Concurrence of Autism Spectrum Disorder and Obsessive Compulsive Disorder in Children and Adolescents: A Systematic Review and Meta-Analysis

  • Claudia Aymerich,
  • Malein Pacho,
  • Ana Catalan,
  • Noorulain Yousaf,
  • Violeta Pérez-Rodríguez,
  • Matthew J. Hollocks,
  • Mara Parellada,
  • Georgina Krebs,
  • Bruce Clark and
  • Gonzalo Salazar de Pablo

Background: Autism spectrum disorder (ASD) and obsessive compulsive disorder (OCD) are two common and impairing neurodevelopmental conditions with partial symptomatic overlap. The aim of this study is to systematically and meta-analytically examine t...

  • Article
  • Open Access
4 Citations
4,116 Views
26 Pages

This study aimed to investigate the effects of intranasal air-puffing on cognitive impairments and brain cortical activity following one night of partial sleep deprivation (PSD) in adults. A total of 26 healthy adults underwent the numerical Stroop t...

  • Article
  • Open Access
1 Citations
2,351 Views
12 Pages

The aim of this study was to assess the rates of depression, anxiety, and stress and quality of sleeping among COVID-19 patients with and without type 2 diabetes mellitus (T2DM). A case and control design has been employed, involving patients affecte...

  • Article
  • Open Access
2 Citations
2,387 Views
17 Pages

Sensorimotor Network Segregation Predicts Long-Term Learning of Writing Skills in Parkinson’s Disease

  • Nicholas D’Cruz,
  • Joni De Vleeschhauwer,
  • Martina Putzolu,
  • Evelien Nackaerts,
  • Moran Gilat and
  • Alice Nieuwboer

The prediction of motor learning in Parkinson’s disease (PD) is vastly understudied. Here, we investigated which clinical and neural factors predict better long-term gains after an intensive 6-week motor learning program to ameliorate micrograp...

  • Article
  • Open Access
10 Citations
3,651 Views
16 Pages

A Data Augmentation Method for Motor Imagery EEG Signals Based on DCGAN-GP Network

  • Xiuli Du,
  • Xiaohui Ding,
  • Meiling Xi,
  • Yana Lv,
  • Shaoming Qiu and
  • Qingli Liu

Motor imagery electroencephalography (EEG) signals have garnered attention in brain–computer interface (BCI) research due to their potential in promoting motor rehabilitation and control. However, the limited availability of labeled data poses...

  • Review
  • Open Access
4 Citations
8,091 Views
12 Pages

This review provided a comprehensive examination of various theories that attempt to explain hypnosis, focusing on the interplay between conscious and unconscious processes. We conducted a thorough analysis of key theories, from historical origins to...

  • Article
  • Open Access
4 Citations
8,837 Views
14 Pages

Transcranial direct current stimulation (tDCS) is a non-invasive and painless technique of brain neuromodulation that applies a low-intensity galvanic current to the scalp with the aim of stimulating specific areas of the brain. Preliminary investiga...

  • Review
  • Open Access
6 Citations
4,666 Views
31 Pages

The primary visual cortex (V1) is one of the most studied regions of the brain and is characterized by its specialized and laminated layer 4 in human and non-human primates. However, studies aiming to harmonize the definition of the cortical layers a...

  • Article
  • Open Access
1 Citations
2,400 Views
15 Pages

Modulation of Corticospinal Excitability during Action Observation in Patients with Disorders of Consciousness

  • Mauro Mancuso,
  • Lucia Mencarelli,
  • Laura Abbruzzese,
  • Benedetta Basagni,
  • Pierluigi Zoccolotti,
  • Cristiano Scarselli,
  • Simone Capitani,
  • Francesco Neri,
  • Emiliano Santarnecchi and
  • Simone Rossi

Brain imaging studies have recently provided some evidence in favor of covert cognitive processes that are ongoing in patients with disorders of consciousness (DoC) (e.g., a minimally conscious state and vegetative state/unresponsive wakefulness synd...

  • Correction
  • Open Access
1,089 Views
2 Pages

Correction: Spanò et al. Effect of Dual-Task Motor-Cognitive Training in Preventing Falls in Vulnerable Elderly Cerebrovascular Patients: A Pilot Study. Brain Sci. 2022, 12, 168

  • Barbara Spanò,
  • Maria G. Lombardi,
  • Massimo De Tollis,
  • Maria A. Szczepanska,
  • Claudia Ricci,
  • Alice Manzo,
  • Simone Giuli,
  • Lorenzo Polidori,
  • Ivo A. Griffini and
  • Roberta Annicchiarico
  • + 2 authors

In the original publication [...]

  • Article
  • Open Access
3 Citations
5,278 Views
9 Pages

Selective Vestibular Neurectomy through the Presigmoid Retrolabyrinthine Approach in the Treatment of Meniere’s Disease

  • Fabrizio Salvinelli,
  • Francesca Bonifacio,
  • Mara Capece,
  • Denis Aiudi,
  • Alessio Iacoangeli,
  • Fabio Greco,
  • Maurizio Gladi and
  • Maurizio Iacoangeli

Background: Meniere’s disease (MD) is a disabling disease, especially in patients who are refractory to medical therapy. Moreover, selective vestibular neurectomy (VN), in these selected cases, can be considered a surgical alternative which pre...

  • Article
  • Open Access
2,098 Views
15 Pages

Objective: The neural basis of threat perception has mostly been examined separately for social or physical threats. However, most of the threats encountered in everyday life are complex. The features of interactions between social and physiological...

  • Article
  • Open Access
11 Citations
3,869 Views
17 Pages

Electroencephalographic Signal Data Augmentation Based on Improved Generative Adversarial Network

  • Xiuli Du,
  • Xinyue Wang,
  • Luyao Zhu,
  • Xiaohui Ding,
  • Yana Lv,
  • Shaoming Qiu and
  • Qingli Liu

EEG signals combined with deep learning play an important role in the study of human–computer interaction. However, the limited dataset makes it challenging to study EEG signals using deep learning methods. Inspired by the GAN network in image...

  • Article
  • Open Access
2 Citations
3,078 Views
14 Pages

Exploring the Relationship between Neuroticism and Perinatal Depressive Symptoms: Findings from a 2-Year, Multicenter Study in Italy

  • Melania Severo,
  • Annamaria Petito,
  • Antonio Ventriglio,
  • Salvatore Iuso,
  • Giulio Ianzano,
  • Alessia Marconcini,
  • Elisa Giannaccari,
  • Giuseppe Luigi Palma,
  • Mario Altamura and
  • Antonello Bellomo
  • + 4 authors

Neuroticism is a personality trait associated with the risk of affective disorders and perinatal depression. We investigated the relationship between different levels of neuroticism, psychological characteristics, and depressive symptoms in a sample...

  • Correction
  • Open Access
1 Citations
1,893 Views
1 Page

Correction: Toader et al. Cognitive Crescendo: How Music Shapes the Brain’s Structure and Function. Brain Sci. 2023, 13, 1390

  • Corneliu Toader,
  • Calin Petru Tataru,
  • Ioan-Alexandru Florian,
  • Razvan-Adrian Covache-Busuioc,
  • Bogdan-Gabriel Bratu,
  • Luca Andrei Glavan,
  • Andrei Bordeianu,
  • David-Ioan Dumitrascu and
  • Alexandru Vlad Ciurea

In the original publication [...]

  • Systematic Review
  • Open Access
15 Citations
10,353 Views
47 Pages

Review of EEG Affective Recognition with a Neuroscience Perspective

  • Rosary Yuting Lim,
  • Wai-Cheong Lincoln Lew and
  • Kai Keng Ang

Emotions are a series of subconscious, fleeting, and sometimes elusive manifestations of the human innate system. They play crucial roles in everyday life—influencing the way we evaluate ourselves, our surroundings, and how we interact with our...

  • Correction
  • Open Access
1,126 Views
2 Pages

Correction: Dreismickenbecker et al. Electroencephalography-Based Effects of Acute Alcohol Intake on the Pain Matrix. Brain Sci. 2023, 13, 1659

  • Elias Dreismickenbecker,
  • Sebastian Zinn,
  • Mara Romero-Richter,
  • Madeline Kohlhaas,
  • Lukas R. Fricker,
  • Silvana Petzel-Witt,
  • Carmen Walter,
  • Matthias Kreuzer,
  • Stefan W. Toennes and
  • Malte Anders

This paper [...]

  • Systematic Review
  • Open Access
1 Citations
4,142 Views
20 Pages

Tic-Related Obsessive–Compulsive and Eating Disorders in Dandy–Walker Variant: A Case Report and Systematic Reappraisal of Psychiatric Profiles

  • Riccardo Bortoletto,
  • Anna Candolo,
  • Alessandra Nicotra,
  • Luana Saetti,
  • Laura Perini,
  • Matteo Balestrieri,
  • Marco Colizzi and
  • Carla Comacchio

Dandy–Walker complex (DWC) consists of a continuum of brain malformations involving the posterior fossa, often leading to psychiatric manifestations during adulthood. We discussed the case of a young woman with Dandy–Walker variant (DWV)...

  • Article
  • Open Access
5 Citations
2,415 Views
12 Pages

Chronic opioid treatments dysregulate the glutamatergic system, inducing a hyperglutamatergic state in mesocorticolimbic brain regions. This study investigated the effects of exposure to hydrocodone overdose on locomotor activity, expression of targe...

  • Article
  • Open Access
2 Citations
2,101 Views
13 Pages

The foveal load effect is one of the most fundamental effects in reading psychology, and also one of the most controversial issues in recent years. The foveal load effect refers to the phenomenon that the difficulty of foveal processing affects paraf...

  • Review
  • Open Access
11 Citations
10,184 Views
25 Pages

The Effect of Antipsychotics on Cognition in Schizophrenia—A Current Narrative Review

  • Petru Fabian Lungu,
  • Corina Miruna Lungu,
  • Alin Ciobica,
  • Ioana Miruna Balmus,
  • Raluca Vitalaru,
  • Ioannis Mavroudis,
  • Romeo Dobrin,
  • Mirela Cimpeanu and
  • Irina Luciana Gurzu

The majority of schizophrenia-affected individuals display deficiencies in multiple cognitive domains such as attention, working memory, long-term memory, and learning, deficiencies that are stable throughout the disease. The purpose of this narrativ...

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Brain Sci. - ISSN 2076-3425