In Vivo Determination of Skin Absorption Coefficient in a Mexican Cohort

Amezcua-López, Erick Enrique; Corral-Martínez, Luis Francisco; Trujillo-Schiaffino, Gerardo; Salas-Peimbert, Didia Patricia; Anguiano-Morales, Marcelino; Ramírez-Quintana, Juan Alberto

doi:10.3390/app16021021

Open AccessArticle

In Vivo Determination of Skin Absorption Coefficient in a Mexican Cohort

by

Erick Enrique Amezcua-López

^*

,

Luis Francisco Corral-Martínez

^*

,

Gerardo Trujillo-Schiaffino

,

Didia Patricia Salas-Peimbert

,

Marcelino Anguiano-Morales

and

Juan Alberto Ramírez-Quintana

División de Estudios de Posgrado e Investigación, Tecnológico Nacional de México/Instituto Tecnológico de Chihuahua, Chihuahua 31200, Mexico

^*

Authors to whom correspondence should be addressed.

Appl. Sci. 2026, 16(2), 1021; https://doi.org/10.3390/app16021021

Submission received: 29 November 2025 / Revised: 31 December 2025 / Accepted: 7 January 2026 / Published: 19 January 2026

(This article belongs to the Special Issue Advanced Devices, Biomedical Technologies and Their Applications in Dermatology)

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Abstract

We determined the in vivo absorption coefficient (μ_a) for 82 test subjects, all classified as Fitzpatrick skin phototypes II, III, IV, and V. Measurements were conducted using the integrating-sphere technique on the dorsal and palmar surfaces of the hand and the forearm. The reflectance data obtained were processed using the Inverse Adding Doubling algorithm to calculate the absorption coefficient. The mean values for this parameter ranged from 0.0132 mm⁻¹ to 0.1021 mm⁻¹ at a central wavelength of 624 nm. It was found that these parameters may be grouped into a distinct cohort, paving the way for studies and the design of light-based diagnostics and treatments better suited to the population in Mexico and Latin America.

Keywords: skin optical model; absorption coefficient; Fitzpatrick scale; Mexican population; Montecarlo simulation

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MDPI and ACS Style

Amezcua-López, E.E.; Corral-Martínez, L.F.; Trujillo-Schiaffino, G.; Salas-Peimbert, D.P.; Anguiano-Morales, M.; Ramírez-Quintana, J.A. In Vivo Determination of Skin Absorption Coefficient in a Mexican Cohort. Appl. Sci. 2026, 16, 1021. https://doi.org/10.3390/app16021021

AMA Style

Amezcua-López EE, Corral-Martínez LF, Trujillo-Schiaffino G, Salas-Peimbert DP, Anguiano-Morales M, Ramírez-Quintana JA. In Vivo Determination of Skin Absorption Coefficient in a Mexican Cohort. Applied Sciences. 2026; 16(2):1021. https://doi.org/10.3390/app16021021

Chicago/Turabian Style

Amezcua-López, Erick Enrique, Luis Francisco Corral-Martínez, Gerardo Trujillo-Schiaffino, Didia Patricia Salas-Peimbert, Marcelino Anguiano-Morales, and Juan Alberto Ramírez-Quintana. 2026. "In Vivo Determination of Skin Absorption Coefficient in a Mexican Cohort" Applied Sciences 16, no. 2: 1021. https://doi.org/10.3390/app16021021

APA Style

Amezcua-López, E. E., Corral-Martínez, L. F., Trujillo-Schiaffino, G., Salas-Peimbert, D. P., Anguiano-Morales, M., & Ramírez-Quintana, J. A. (2026). In Vivo Determination of Skin Absorption Coefficient in a Mexican Cohort. Applied Sciences, 16(2), 1021. https://doi.org/10.3390/app16021021

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In Vivo Determination of Skin Absorption Coefficient in a Mexican Cohort

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