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Applied Sciences
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Advanced Devices, Biomedical Technologies and Their Applications in Dermatology
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Advanced Devices, Biomedical Technologies and Their Applications in Dermatology

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: 20 July 2026 | Viewed by 1597

Special Issue Editors

Dr. Foteini Biskanaki

E-Mail Website1 Website2
Guest Editor
1. First Department of Pathology, School of Medicine, The National and Kapodistrian University of Athens, GR-11527 Athens, Greece
2. Department of Biomedical Sciences, School of Health and Care Sciences, University of West Attica, GR-12243 Athens, Greece
Interests: ageing; biomedical technologies in aesthetic and cosmetology; non-invasive body contouring technologies
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Dimitrios Chaniotis

E-Mail Website
Guest Editor
Department of Biomedical Sciences, School of Health and Care Sciences, University of West Attica, GR-12243 Athens, Greece
Interests: animal coronaviruses; apoptosis; apoptotic pathways; sexually transmitted diseases; awareness; knowledge score; Greek young adults; breast cancer; ER-negative; EGFR; TKIs; RANK-c
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The continuous advancement of technology in the field of dermatology has led to the emergence of numerous innovative applications aimed at the restoration and enhancement of various conditions affecting the skin and subcutaneous tissue. These technological innovations fall under the domain of biomedical technology and include sophisticated, non-invasive devices that function through the generation and transmission of energy to biological tissues.

Biomedical technology has significantly transformed our understanding of human physiology and pathology, offering new tools for the diagnosis, treatment, and prevention of dermatological conditions. Of particular relevance is the intersection of biomedical technology with aesthetic dermatology, medical aesthetics, and cosmetology. As with any medical application, technologies intended for human use must prioritise patient safety, delivering therapeutic benefits without introducing undue risks or complications. Achieving this requires a thorough understanding of the mechanisms of action of each device, an in-depth knowledge of skin physiology, and accurate diagnosis of aesthetic concerns such as wrinkles, skin laxity, dehydration, cellulite, etc.

The availability and advancement of cutting-edge technologies in aesthetic dermatology are of paramount importance. Equally critical is the role of healthcare professionals in accurately assessing dermatological needs and selecting the most appropriate technological interventions, whether individually or in combination.

In this context, we are seeking original research articles, review papers, and comparative studies that explore the safety, efficacy, and clinical applications of advanced devices and technologies in aesthetic dermatology. Topics of interest include, but are not limited to, the following:

  • Invasive and non-invasive advanced technologies for skin rejuvenation and fat reduction.
  • Innovations in laser-based aesthetic procedures.
  • Advances in ultrasound-based treatments (e.g., HIFU, MFU-V).
  • Cutting-edge devices in cryotherapy and thermotherapy.
  • Mesotherapy and radiofrequency technologies.
  • Complications and adverse effects associated with advanced aesthetic procedures.
  • Clinical investigation and refinement of both invasive and non-invasive dermatological technologies.
  • Novel insights into the synergistic effects of combining modern technologies.
  • Development and validation of combination treatment protocols.
  • Randomised controlled trials assessing the long-term safety and effectiveness of these technologies.
  • Clinical case studies demonstrating applications and outcomes.

We welcome original contributions that highlight recent advancements and technical developments in this field. Submissions may include experimental studies, clinical trials, systematic reviews, and comparative analyses.

Dr. Foteini Biskanaki
Prof. Dr. Dimitrios Chaniotis
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ageing
  • acne scars
  • aesthetic procedures
  • aesthetic dermatology
  • biomedical science in aesthetics
  • cellulite
  • laser
  • ultrasound
  • non-invasive devices
  • mesotherapy

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Published Papers (2 papers)

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Research

12 pages, 922 KB  
Article
HIFU and the Oxidative Echo: A Pilot Investigation of Free Radical Stress in Facial and Neck Procedures
by Foteini Biskanaki, Dimitrios Chaniotis, Ioanna A. Anastasiou, Nikolaos Tentolouris, Vasilis Papadopoulos, George Skouras, Angeliki M. Mavreli, Fragiskos Chanioitis, Evaggelia Protopapa, Athanasia Varvaresou and Andreas C. Lazaris
Appl. Sci. 2026, 16(3), 1558; https://doi.org/10.3390/app16031558 - 4 Feb 2026
Viewed by 410
Abstract
Background: High-Intensity Focused Ultrasound (HIFU) is widely used for non-invasive facial and neck rejuvenation, promoting collagen remodeling through controlled thermal and mechanical effects. While its clinical outcomes are well established, the immediate biochemical response—particularly oxidative stress—has not been directly quantified in humans. Objective: [...] Read more.
Background: High-Intensity Focused Ultrasound (HIFU) is widely used for non-invasive facial and neck rejuvenation, promoting collagen remodeling through controlled thermal and mechanical effects. While its clinical outcomes are well established, the immediate biochemical response—particularly oxidative stress—has not been directly quantified in humans. Objective: This pilot study aimed to evaluate acute changes in oxidative stress levels following a single HIFU session in healthy adult volunteers. Methods: Nineteen healthy volunteers were enrolled; fourteen received HIFU treatment and five served as contemporaneous controls. Venous blood samples were collected at baseline and immediately after treatment (or 40 min later for controls). Oxidative stress levels were quantified using an enzyme-linked immunosorbent assay (ELISA). Pre–post differences were assessed using paired t-tests, and between-group comparisons were performed using Δ-scores and mixed-effects modeling. Results: Oxidative index values remained unchanged in controls (18.55 ± 0.57 μmol/L pre vs. 18.55 ± 0.57 μmol/L post; Δ = 0.00 ± 0.00; p = 1.00). In contrast, HIFU treatment induced a significant acute increase (19.99 ± 1.54 μmol/L pre vs. 22.39 ± 2.29 μmol/L post; Δ = 2.63 ± 2.22 μmol/L; p = 0.0007). Between-group Δ differences were significant, and mixed-effects modeling revealed a significant time × group interaction, indicating an HIFU-specific oxidative response. No adverse effects were observed, and all treated participants demonstrated immediate aesthetic improvement. Conclusions: A single HIFU session elicits an acute increase in oxidative stress, likely reflecting controlled thermal stimulation and early tissue remodeling. Longitudinal studies are warranted to assess the persistence of these biochemical changes and their contribution to long-term clinical outcomes. Full article
(This article belongs to the Special Issue Advanced Devices, Biomedical Technologies and Their Applications in Dermatology)
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16 pages, 1020 KB  
Article
In Vivo Determination of Skin Absorption Coefficient in a Mexican Cohort
by Erick Enrique Amezcua-López, Luis Francisco Corral-Martínez, Gerardo Trujillo-Schiaffino, Didia Patricia Salas-Peimbert, Marcelino Anguiano-Morales and Juan Alberto Ramírez-Quintana
Appl. Sci. 2026, 16(2), 1021; https://doi.org/10.3390/app16021021 - 19 Jan 2026
Viewed by 689
Abstract
We determined the in vivo absorption coefficient (μa) for 82 test subjects, all classified as Fitzpatrick skin phototypes II, III, IV, and V. Measurements were conducted using the integrating-sphere technique on the dorsal and palmar surfaces of the hand and [...] Read more.
We determined the in vivo absorption coefficient (μa) for 82 test subjects, all classified as Fitzpatrick skin phototypes II, III, IV, and V. Measurements were conducted using the integrating-sphere technique on the dorsal and palmar surfaces of the hand and the forearm. The reflectance data obtained were processed using the Inverse Adding Doubling algorithm to calculate the absorption coefficient. The mean values for this parameter ranged from 0.0132 mm−1 to 0.1021 mm−1 at a central wavelength of 624 nm. It was found that these parameters may be grouped into a distinct cohort, paving the way for studies and the design of light-based diagnostics and treatments better suited to the population in Mexico and Latin America. Full article
(This article belongs to the Special Issue Advanced Devices, Biomedical Technologies and Their Applications in Dermatology)
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