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Applied Sciences
Volume 15
Issue 17
10.3390/app15179533
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Biological Activity of Resveratrol, a Plant-Derived Polyphenol, in Combination with Orlistat: A Preclinical Study on Anti-Obesity Effects

by
Abraham Escobedo-Moratilla
1,†,
Omar Patiño-Rodríguez
2,
Angélica Arzola-Paniagua
3,
José Luis Herrera
3,
Juan Pablo Senosiain
3 and
José Pérez-Urizar
4,5,*
1
SECIHTI-Consorcio de Investigación, Innovación y Desarrollo para las Zonas Áridas, San Luis Potosí 78216, SLP, Mexico
2
SECIHTI-CEPROBI, Instituto Politécnico Nacional, Yautepec 62739, MOR, Mexico
3
Laboratorios Senosiain S.A. de C.V., Mexico City 11560, Mexico
4
Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, San Luis Potosí 78210, SLP, Mexico
5
FS Scientia Pharma S.A. de C.V., San Luis Potosí 78210, SLP, Mexico
*
Author to whom correspondence should be addressed.
†
Current address: Health Affairs Consulting SAPI de C.V., San Luis Potosí 78210, SLP, Mexico.
Appl. Sci. 2025, 15(17), 9533; https://doi.org/10.3390/app15179533 (registering DOI)
Submission received: 22 July 2025 / Revised: 23 August 2025 / Accepted: 27 August 2025 / Published: 29 August 2025
(This article belongs to the Special Issue Biological Activities of Medicinal Plants and Their Potential Applications)
Versions Notes

Abstract

Resveratrol (RVT) is a plant-derived polyphenol found in traditional medicinal species such as Veratrum grandiflorum and Polygonum cuspidatum, known for their bioactive secondary metabolites. This study evaluates the anti-obesity effects of RVT alone and in combination with orlistat (OLT), a pharmaceutical lipase inhibitor, in a high-fat diet-induced obesity model in rats. Female Sprague-Dawley rats were assigned to receive RVT, OLT, a combination of both, or no treatment, over a four-week period. The combination of RVT and OLT led to a significant reduction in body weight gain and improvement in lipid profiles, including decreased LDL cholesterol. Additionally, the combination ameliorated liver enzyme elevations associated with obesity-related hepatic stress. These findings demonstrate that resveratrol potentiates orlistat’s pharmacological efficacy and highlights the therapeutic potential of bioactive compounds from medicinal plants in metabolic disease management. This study supports further development of plant-based pharmacological agents and synergistic formulations for the treatment of obesity and associated comorbidities.
Keywords: resveratrol; orlistat; medicinal plants; biological activity; preclinical evaluation; diet-induced obesity; combination resveratrol; orlistat; medicinal plants; biological activity; preclinical evaluation; diet-induced obesity; combination

Share and Cite

MDPI and ACS Style

Escobedo-Moratilla, A.; Patiño-Rodríguez, O.; Arzola-Paniagua, A.; Herrera, J.L.; Senosiain, J.P.; Pérez-Urizar, J. Biological Activity of Resveratrol, a Plant-Derived Polyphenol, in Combination with Orlistat: A Preclinical Study on Anti-Obesity Effects. Appl. Sci. 2025, 15, 9533. https://doi.org/10.3390/app15179533

AMA Style

Escobedo-Moratilla A, Patiño-Rodríguez O, Arzola-Paniagua A, Herrera JL, Senosiain JP, Pérez-Urizar J. Biological Activity of Resveratrol, a Plant-Derived Polyphenol, in Combination with Orlistat: A Preclinical Study on Anti-Obesity Effects. Applied Sciences. 2025; 15(17):9533. https://doi.org/10.3390/app15179533

Chicago/Turabian Style

Escobedo-Moratilla, Abraham, Omar Patiño-Rodríguez, Angélica Arzola-Paniagua, José Luis Herrera, Juan Pablo Senosiain, and José Pérez-Urizar. 2025. "Biological Activity of Resveratrol, a Plant-Derived Polyphenol, in Combination with Orlistat: A Preclinical Study on Anti-Obesity Effects" Applied Sciences 15, no. 17: 9533. https://doi.org/10.3390/app15179533

APA Style

Escobedo-Moratilla, A., Patiño-Rodríguez, O., Arzola-Paniagua, A., Herrera, J. L., Senosiain, J. P., & Pérez-Urizar, J. (2025). Biological Activity of Resveratrol, a Plant-Derived Polyphenol, in Combination with Orlistat: A Preclinical Study on Anti-Obesity Effects. Applied Sciences, 15(17), 9533. https://doi.org/10.3390/app15179533

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