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Volume 11
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10.3390/app11083505
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Article

Bovine Dialyzable Leukocyte Extract IMMUNEPOTENT CRP: Evaluation of Biological Activity of the Modified Product

by
Moisés Armides Franco-Molina
*,
Silvia Elena Santana-Krímskaya
,
Diana Ginette Zarate-Triviño
,
Pablo Zapata-Benavides
,
Sara Paola Hernández-Martínez
,
Fernanda Cervantes-Wong
and
Cristina Rodríguez-Padilla
Laboratorio de Inmunología y Virología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León (UANL), P.O. Box 46 “F”, San Nicolás de los Garza 66455, Mexico
*
Author to whom correspondence should be addressed.
Appl. Sci. 2021, 11(8), 3505; https://doi.org/10.3390/app11083505
Submission received: 12 March 2021 / Revised: 6 April 2021 / Accepted: 12 April 2021 / Published: 14 April 2021
(This article belongs to the Section Applied Biosciences and Bioengineering)
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Abstract

Dialyzable leukocyte extracts are clinically used under different commercial names (IMMUNEPOTENT CRP®, IMMODIN®, Transferon®) to modulate the immune response altered by pathological conditions such as cancer, inflammation, and viral infections. The purpose of this study is to improve the production process of bovine dialyzable leukocyte extract without decreasing its biological activities (antioxidant, anti-inflammatory, and antitumoral). Our product modification consists of adding a dry heating step in the production process. In this study, we evaluated and compared the chemical composition (bromatological analysis), physical structure (infrared spectroscopy, X-ray diffraction, SEM, and zeta potential) and biological function of the dialyzable leukocyte extracts obtained from fresh and dry bovine spleens. Our results showed that the use of a drying step in the production process of the bovine dialyzable leukocyte extract (bDLE) did not affect its antioxidant and anti-inflammatory effects and it improved its antitumor properties. We suggest that this process modification could be applied to other biological products, such as dialyzable leukocyte extracts derived from other sources, in order to improve its functionality and formulation.
Keywords: dialyzable leukocyte extract; characterization; immunotherapy; antioxidant; anti-inflammatory; antitumor dialyzable leukocyte extract; characterization; immunotherapy; antioxidant; anti-inflammatory; antitumor

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MDPI and ACS Style

Franco-Molina, M.A.; Santana-Krímskaya, S.E.; Zarate-Triviño, D.G.; Zapata-Benavides, P.; Hernández-Martínez, S.P.; Cervantes-Wong, F.; Rodríguez-Padilla, C. Bovine Dialyzable Leukocyte Extract IMMUNEPOTENT CRP: Evaluation of Biological Activity of the Modified Product. Appl. Sci. 2021, 11, 3505. https://doi.org/10.3390/app11083505

AMA Style

Franco-Molina MA, Santana-Krímskaya SE, Zarate-Triviño DG, Zapata-Benavides P, Hernández-Martínez SP, Cervantes-Wong F, Rodríguez-Padilla C. Bovine Dialyzable Leukocyte Extract IMMUNEPOTENT CRP: Evaluation of Biological Activity of the Modified Product. Applied Sciences. 2021; 11(8):3505. https://doi.org/10.3390/app11083505

Chicago/Turabian Style

Franco-Molina, Moisés Armides, Silvia Elena Santana-Krímskaya, Diana Ginette Zarate-Triviño, Pablo Zapata-Benavides, Sara Paola Hernández-Martínez, Fernanda Cervantes-Wong, and Cristina Rodríguez-Padilla. 2021. "Bovine Dialyzable Leukocyte Extract IMMUNEPOTENT CRP: Evaluation of Biological Activity of the Modified Product" Applied Sciences 11, no. 8: 3505. https://doi.org/10.3390/app11083505

APA Style

Franco-Molina, M. A., Santana-Krímskaya, S. E., Zarate-Triviño, D. G., Zapata-Benavides, P., Hernández-Martínez, S. P., Cervantes-Wong, F., & Rodríguez-Padilla, C. (2021). Bovine Dialyzable Leukocyte Extract IMMUNEPOTENT CRP: Evaluation of Biological Activity of the Modified Product. Applied Sciences, 11(8), 3505. https://doi.org/10.3390/app11083505

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