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Applied Sciences, Volume 10, Issue 18

September-2 2020 - 483 articles

Cover Story: The capability of emodin to prevent the interaction between the coronavirus’s spike protein and its human target receptor was proven 10 years ago, though the underpinning molecular mechanisms were not clearly described. This lack of knowledge prevents the rational use of emodin and related compounds to develop molecules that efficiently prevent viral infection. Our study provided a mechanistic rationale and the plausible mechanism of action of emodin is described as an interaction at the protein–protein interface that destabilizes the viral protein–target receptor complex. This knowledge-based foothold could provide a solid basis for the potential development of efficient antiviral cognate compounds. View this paper
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Articles (483)

  • Article
  • Open Access
3 Citations
3,075 Views
12 Pages

Dosimetric Issues Associated with Percutaneous Ablation of Small Liver Lesions with 90Y

  • Marco D’Arienzo,
  • Anna Sarnelli,
  • Emilio Mezzenga,
  • Laura Chiacchiararelli,
  • Antonino Amato,
  • Massimo Romanelli,
  • Roberto Cianni,
  • Marta Cremonesi and
  • Giovanni Paganelli

22 September 2020

The aim of the present paper is twofold. Firstly, to assess the absorbed dose in small lesions using Monte Carlo calculations in a scenario of intratumoral injection of 90Y (e.g., percutaneous ablation). Secondly, to derive a practical analytical for...

  • Article
  • Open Access
7 Citations
3,298 Views
20 Pages

Multidomain Simulation Model for Analysis of Geometric Variation and Productivity in Multi-Stage Assembly Systems

  • Sergio Benavent Nácher,
  • Pedro Rosado Castellano,
  • Fernando Romero Subirón and
  • José V. Abellán-Nebot

22 September 2020

Nowadays, the new era of industry 4.0 is forcing manufacturers to develop models and methods for managing the geometric variation of a final product in complex manufacturing environments, such as multistage manufacturing systems. The stream of variat...

  • Article
  • Open Access
24 Citations
6,051 Views
23 Pages

22 September 2020

The blockchain is a distributed ledger technology that is growing in importance since inception. Besides cryptocurrencies, it has also crossed its boundary inspiring various organizations, enterprises, or business establishments to adopt this technol...

  • Article
  • Open Access
6 Citations
3,194 Views
18 Pages

22 September 2020

The wear rate and dissipation energy during tension–torsion cyclic loading of steel wires with fretting contact in different environmental media were explored in this study. Hysteresis loops of tangential force versus displacement amplitude (Ft...

  • Article
  • Open Access
13 Citations
4,666 Views
16 Pages

Assessing Significant Factors Affecting Risky Riding Behaviors of Motorcyclists

  • Wins Cott Goh,
  • Lee Vien Leong and
  • Richard Jun Xian Cheah

22 September 2020

This study was conducted in Malaysia, where motorcycle traffic accidents represent a high percentage of fatality among overall traffic accidents. Studies have shown that risk perception and positive outcome of risky riding behavior have a significant...

  • Article
  • Open Access
7 Citations
4,153 Views
21 Pages

22 September 2020

The problem of scheduling parallel tasks graphs (PTGs) represented by directed acyclic graphs (DAGs) in heterogeneous distributed computing systems (HDCSs) is considered an nondeterministic polynomial time (NP) problem due to the diversity of charact...

  • Article
  • Open Access
18 Citations
3,509 Views
14 Pages

From the Point Cloud to BIM Methodology for the Ideal Reconstruction of a Lost Bastion of the Cáceres Wall

  • Pablo Alejandro Cruz Franco,
  • Adela Rueda Márquez de la Plata and
  • Jesús Cruz Franco

22 September 2020

Thanks to the use of non-invasive techniques and remote sensing in a 19th century building, it was possible to demonstrate that said building is a lost part of the Cáceres wall. This wall was believed to maintain the straight line from a known...

  • Article
  • Open Access
19 Citations
12,007 Views
21 Pages

22 September 2020

Multispeed transmissions are helpful for improvement of the economy and drivability of electric vehicles (EVs). In this paper, we propose a two-speed transmission based on dual planetary gear mechanism, in which shifts are realized by torque transfer...

  • Article
  • Open Access
7 Citations
3,218 Views
14 Pages

Intersection Routing Based on Fuzzy Multi-Factor Decision for VANETs

  • Zhenbo Cao,
  • Bhagya Nathali Silva,
  • Muhammad Diyan,
  • Jilong Li and
  • Kijun Han

22 September 2020

Vehicular ad hoc network (VANET) is a special form of mobile ad hoc network (MANET), which plays a key role in the intelligent transportation system (ITS). Though many outstanding geographic routing protocols are designed for VANETs, a majority of th...

  • Feature Paper
  • Review
  • Open Access
171 Citations
13,908 Views
24 Pages

22 September 2020

Conducting polymers are an important class of functional materials that has been widely applied to fabricate electrochemical biosensors, because of their interesting and tunable chemical, electrical, and structural properties. Conducting polymers can...

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Appl. Sci. - ISSN 2076-3417