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Animals
Volume 9
Issue 11
10.3390/ani9110858
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Article

Association of Twelve Candidate Gene Polymorphisms with the Intramuscular Fat Content and Average Backfat Thickness of Chinese Suhuai Pigs

by
Binbin Wang
1,2,
Pinghua Li
1,2,*,
Wuduo Zhou
1,
Chen Gao
1,2,
Hang Liu
1,2,
Huixia Li
1,
Peipei Niu
2,
Zongping Zhang
2,
Qiang Li
3,
Juan Zhou
3 and
Ruihua Huang
1,2,*
1
Institute of Swine Science, Nanjing Agricultural University, Nanjing 210095, China
2
Huaian Academy, Nanjing Agricultural University, Huaian 223005, China
3
Huaiyin Pig Breeding Farm of Huaian City, Huaian 223322, China
*
Authors to whom correspondence should be addressed.
Animals 2019, 9(11), 858; https://doi.org/10.3390/ani9110858
Received: 2 September 2019 / Revised: 18 October 2019 / Accepted: 21 October 2019 / Published: 23 October 2019
(This article belongs to the Collection Applications of Quantitative Genetics in Livestock Production)
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Simple Summary

Appropriate intramuscular fat content (IFC) is the goal of consumers and the direction that breeders must pursue. However, it is difficult to improve the IFC but not average backfat thickness (ABT) by traditional breeding methods, and pigs must be slaughtered to accurately measure IFC. Marker-assisted selection (MAS) provides an economic and efficient method to improve the IFC in pigs. Our research indicated that the FABP3 (rs1110770079) single nucleotide polymorphism (SNP) could be a candidate gene associated with IFC (but not ABT), and IFC could be improved by selecting the individuals with a favorable genotype (GG) of FABP3 (rs1110770079) SNP for pig breeding.

Abstract

The present study aimed to identify the molecular markers for genes that influence intramuscular fat content (IFC), but not average backfat thickness (ABT). A total of 330 Suhuai pigs were slaughtered, and measurements of IFC and ABT were obtained. Phenotypic and genetic correlations between IFC and ABT were calculated. Thirteen single nucleotide polymorphisms (SNPs) among 12 candidate genes for IFC were analyzed, including FABP3, LIPE, IGF1, IGF2, LEP, LEPR, MC4R, PHKG1, RETN, RYR1, SCD, and UBE3C. Associations of the evaluated SNPs with IFCIFC and ABT were performed. Our results showed that the means of IFC and ABT were 1.99 ± 0.03 % and 26.68 ± 0.28 mm, respectively. The coefficients of variation (CVs) of IFC and ABT were 31.21% and 19.36%, respectively. The phenotypic and genetic correlations between IFC and ABT were moderate. Only the FABP3 (rs1110770079) was associated with IFC (p < 0.05) but not with ABT. Besides, there was a tendency for associations of RYR1 (rs344435545) and SCD (rs80912566) with IFC (p < 0.1). Our results indicated that the FABP3 (rs1110770079) SNP could be used as a marker to improve IFC without changing ABT in the Suhuai pig breeding system. View Full-Text
Keywords: Suhuai pig; intramuscular fat content; average backfat thickness; candidate gene Suhuai pig; intramuscular fat content; average backfat thickness; candidate gene
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MDPI and ACS Style

Wang, B.; Li, P.; Zhou, W.; Gao, C.; Liu, H.; Li, H.; Niu, P.; Zhang, Z.; Li, Q.; Zhou, J.; Huang, R. Association of Twelve Candidate Gene Polymorphisms with the Intramuscular Fat Content and Average Backfat Thickness of Chinese Suhuai Pigs. Animals 2019, 9, 858. https://doi.org/10.3390/ani9110858

AMA Style

Wang B, Li P, Zhou W, Gao C, Liu H, Li H, Niu P, Zhang Z, Li Q, Zhou J, Huang R. Association of Twelve Candidate Gene Polymorphisms with the Intramuscular Fat Content and Average Backfat Thickness of Chinese Suhuai Pigs. Animals. 2019; 9(11):858. https://doi.org/10.3390/ani9110858

Chicago/Turabian Style

Wang, Binbin, Pinghua Li, Wuduo Zhou, Chen Gao, Hang Liu, Huixia Li, Peipei Niu, Zongping Zhang, Qiang Li, Juan Zhou, and Ruihua Huang. 2019. "Association of Twelve Candidate Gene Polymorphisms with the Intramuscular Fat Content and Average Backfat Thickness of Chinese Suhuai Pigs" Animals 9, no. 11: 858. https://doi.org/10.3390/ani9110858

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