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Volume 12
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10.3390/pathogens12040540
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Article

The Brown Alga Bifurcaria bifurcata Presents an Anthelmintic Activity on All Developmental Stages of the Parasitic Nematode Heligmosomoides polygyrus bakeri

by
Morgane Miclon
1,
Élise Courtot
1,
Fabrice Guégnard
1,
Océane Lenhof
1,
Leslie Boudesocque-Delaye
2,
Maria Matard-Mann
3,
Pi Nyvall Collén
3,
Philippe Castagnone-Sereno
4 and
Cédric Neveu
1,*
1
Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Tours, ISP, 37380 Nouzilly, France
2
EA 7502 Synthèse et Isolement de Molécules BioActives (SIMBA), Faculté de Pharmacie, Université de Tours, 31 Avenue Monge, 37200 Tours, France
3
Olmix S.A., 56580 Bréhan, France
4
Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Côte d’Azur, CNRS, ISA, 06903 Sophia Antipolis, France
*
Author to whom correspondence should be addressed.
Pathogens 2023, 12(4), 540; https://doi.org/10.3390/pathogens12040540
Submission received: 21 February 2023 / Revised: 15 March 2023 / Accepted: 28 March 2023 / Published: 30 March 2023
(This article belongs to the Special Issue Parasites: Epidemiology, Treatment and Control)
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Abstract

The current control of gastrointestinal (GI) parasitic nematodes mainly relies on the widespread use of anthelmintics, which has inevitably led to resistance. Therefore, there is an urgent need to find new sources of antiparasitic compounds. Macroalgae represent a rich source of active molecules and are widely described as having medicinal properties. In the present study, we investigated the potential anthelmintic activity of aqueous extracts from three species of algae (Bifurcaria bifurcata, Grateloupia turuturu and Osmundea pinnatifida) on the murine parasite Heligmosomoides polygyrus bakeri. Using a set of complementary in vitro tests, including larval development assays, egg hatching tests and nematicidal activity assays on larvae and adults, we report the nematicidal activity of aqueous extracts of B. bifurcata. In addition, aqueous extract fractionation using liquid/liquid partitioning with a solvent of increasing polarity was performed in order to identify the groups of active molecules underlying the anthelmintic activity. Non-polar extracts (heptane, ethyl acetate) demonstrated high anthelmintic potential, highlighting the role of non-polar metabolites such as terpenes. Here, we highlight the strong anthelmintic potential of the brown alga B. bifurcata on a mouse model of GI parasites, thus confirming the strong interest in algae as natural alternatives for the control of parasitic nematodes.
Keywords: anthelmintic; natural compound; algae; gastrointestinal parasite; nematode; Heligmosomoides polygyrus bakeri; Bifurcaria bifurcata anthelmintic; natural compound; algae; gastrointestinal parasite; nematode; Heligmosomoides polygyrus bakeri; Bifurcaria bifurcata

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MDPI and ACS Style

Miclon, M.; Courtot, É.; Guégnard, F.; Lenhof, O.; Boudesocque-Delaye, L.; Matard-Mann, M.; Nyvall Collén, P.; Castagnone-Sereno, P.; Neveu, C. The Brown Alga Bifurcaria bifurcata Presents an Anthelmintic Activity on All Developmental Stages of the Parasitic Nematode Heligmosomoides polygyrus bakeri. Pathogens 2023, 12, 540. https://doi.org/10.3390/pathogens12040540

AMA Style

Miclon M, Courtot É, Guégnard F, Lenhof O, Boudesocque-Delaye L, Matard-Mann M, Nyvall Collén P, Castagnone-Sereno P, Neveu C. The Brown Alga Bifurcaria bifurcata Presents an Anthelmintic Activity on All Developmental Stages of the Parasitic Nematode Heligmosomoides polygyrus bakeri. Pathogens. 2023; 12(4):540. https://doi.org/10.3390/pathogens12040540

Chicago/Turabian Style

Miclon, Morgane, Élise Courtot, Fabrice Guégnard, Océane Lenhof, Leslie Boudesocque-Delaye, Maria Matard-Mann, Pi Nyvall Collén, Philippe Castagnone-Sereno, and Cédric Neveu. 2023. "The Brown Alga Bifurcaria bifurcata Presents an Anthelmintic Activity on All Developmental Stages of the Parasitic Nematode Heligmosomoides polygyrus bakeri" Pathogens 12, no. 4: 540. https://doi.org/10.3390/pathogens12040540

APA Style

Miclon, M., Courtot, É., Guégnard, F., Lenhof, O., Boudesocque-Delaye, L., Matard-Mann, M., Nyvall Collén, P., Castagnone-Sereno, P., & Neveu, C. (2023). The Brown Alga Bifurcaria bifurcata Presents an Anthelmintic Activity on All Developmental Stages of the Parasitic Nematode Heligmosomoides polygyrus bakeri. Pathogens, 12(4), 540. https://doi.org/10.3390/pathogens12040540

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