You are currently viewing a new version of our website. To view the old version click .

Pathogens, Volume 10, Issue 7

July 2021 - 133 articles

Cover Story: Francisella tularensis (Ft) is a Tier 1 Select Agent of concern for biodefense for which there is no licensed vaccine. Herein, the Ft transporters, FptA and FptF, are evaluated as targets for attenuating mutations in Ft LVS. ΔfptA and ΔfptF mutant strains are attenuated and confer protection against lethal challenge in the mouse model. Furthermore, the data support roles for both transporters in modulating the host immune response to promote Ft’s full virulence. The results support a fundamental requirement for FptA and FptF in the pathogenesis of Ft and their potential as targets in Ft vaccine development. View this paper.
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (133)

  • Study Protocol
  • Open Access
6 Citations
3,655 Views
11 Pages

Nationwide Seroprevalence of SARS-CoV-2 IgG Antibodies among Four Groups of Primary Health-Care Workers and Their Household Contacts 6 Months after the Initiation of the COVID-19 Vaccination Campaign in France: SeroPRIM Study Protocol

  • Marie Pouquet,
  • Dorine Decarreaux,
  • Pol Prévot-Monsacré,
  • Corentin Hervé,
  • Andréas Werner,
  • Brigitte Grosgogeat,
  • Hélène Blanché,
  • Pascaline Rabiega,
  • Julien Laupie and
  • Fabienne Kochert
  • + 14 authors

Background: The protocol study will focus on the seroprevalence of IgG antibodies to SARS-CoV-2 achieved by vaccination and/or natural protection as well as the history, symptoms, and risk factors for SARS-CoV-2 in four primary health-care workers (P...

  • Article
  • Open Access
13 Citations
5,517 Views
30 Pages

Evidence of Immune Modulators in the Secretome of the Equine Tapeworm Anoplocephala perfoliata

  • Boontarikaan Wititkornkul,
  • Benjamin J. Hulme,
  • John J. Tomes,
  • Nathan R. Allen,
  • Chelsea N. Davis,
  • Sarah D. Davey,
  • Alan R. Cookson,
  • Helen C. Phillips,
  • Matthew J. Hegarty and
  • Martin T. Swain
  • + 3 authors

Anoplocephala perfoliata is a neglected gastro-intestinal tapeworm, commonly infecting horses worldwide. Molecular investigation of A. perfoliata is hampered by a lack of tools to better understand the host–parasite interface. This interface is likel...

  • Article
  • Open Access
10 Citations
4,724 Views
22 Pages

(1) Background: Arboviruses of medical and veterinary significance have been identified on all seven continents, with every human and animal population at risk for exposure. Like arboviruses, chronic neurodegenerative diseases, like Alzheimer’s and P...

  • Review
  • Open Access
6 Citations
5,347 Views
14 Pages

Licensing Natural Killers for Antiviral Immunity

  • John M. Cronk,
  • Eleni Fafoutis and
  • Michael G. Brown

Immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors (IRs) enable discrimination between self- and non-self molecules on the surface of host target cells. In this regard, they have a vital role in self-tolerance through binding and...

  • Article
  • Open Access
13 Citations
3,799 Views
15 Pages

Natural Transformation as a Mechanism of Horizontal Gene Transfer in Aliarcobacter butzleri

  • Marina Bonifácio,
  • Cristiana Mateus,
  • Ana R. Alves,
  • Emanuel Maldonado,
  • Ana P. Duarte,
  • Fernanda Domingues,
  • Mónica Oleastro and
  • Susana Ferreira

Aliarcobacter butzleri is an emergent enteropathogen, showing high genetic diversity, which likely contributes to its adaptive capacity to different environments. Whether natural transformation can be a mechanism that generates genetic diversity in A...

  • Article
  • Open Access
12 Citations
4,121 Views
20 Pages

Molecular Characterization of the env Gene of Bovine Leukemia Virus in Cattle from Pakistan with NGS-Based Evidence of Virus Heterogeneity

  • Marzena Rola-Łuszczak,
  • Ali Sakhawat,
  • Aneta Pluta,
  • Anna Ryło,
  • Arkadiusz Bomba,
  • Nazia Bibi and
  • Jacek Kuźmak

Characterization of the global genetic diversity of the bovine leukemia virus (BLV) is an ongoing international research effort. Up to now BLV sequences have been classified into eleven distinct genotypes. Although BLV genotyping and molecular analys...

  • Review
  • Open Access
21 Citations
6,052 Views
19 Pages

The Role of Macrophages in the Host’s Defense against Sporothrix schenckii

  • Estela Ruiz-Baca,
  • Armando Pérez-Torres,
  • Yolanda Romo-Lozano,
  • Daniel Cervantes-García,
  • Carlos A. Alba-Fierro,
  • Javier Ventura-Juárez and
  • Conchita Torriello

The role of immune cells associated with sporotrichosis caused by Sporothrix schenckii is not yet fully clarified. Macrophages through pattern recognition receptors (PRRs) can recognize pathogen-associated molecular patterns (PAMPs) of Sporothrix, en...

  • Review
  • Open Access
4 Citations
4,012 Views
11 Pages

Neisseria meningitidis causes a devastating invasive disease but is also a normal colonizer of the human nasopharynx. Due to the rapid progression of disease, the best tool to protect individuals against meningococcal infections is immunization. Clin...

  • Article
  • Open Access
1 Citations
3,163 Views
10 Pages

Natural Infection of Dairy Cows with Bovine Leukemia Virus Affects Immunoglobulin Levels in Saliva and Serum but Not Milk

  • Monika Dziuba,
  • Vickie J. Ruggiero,
  • Catherine Wilson,
  • Paul C. Bartlett and
  • Paul M. Coussens

Bovine leukemia virus (BLV) is a retroviral infection that disrupts the immune function of infected animals. It is widespread among U.S. dairy cattle. In this pilot study, the average total IgA and IgM concentrations in milk, saliva, and serum sample...

  • Review
  • Open Access
6 Citations
5,930 Views
15 Pages

Cyclophilins are cellular peptidyl-prolyl isomerases that play an important role in viral infections, with demonstrated roles in the replication of hepatitis C virus (HCV) and other viruses in the Flaviviridae family, such as dengue virus (DENV) and...

of 14

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Pathogens - ISSN 2076-0817Creative Common CC BY license