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Volume 10
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10.3390/pathogens10020115
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Article

Detection of Multiple Intracellular Bacterial Pathogens in Haemaphysalis flava Ticks Collected from Hedgehogs in Central China

by
Li-Zhu Fang
1,†,
Si-Cong Lei
1,2,†,
Zhi-Jian Yan
3,
Xiao Xiao
1,4,
Jian-Wei Liu
1,
Xiao-Qing Gong
1,
Hao Yu
1 and
Xue-Jie Yu
1,*
1
State Key Laboratory of Virology, School of Health Sciences, Wuhan University, Wuhan 430071, China
2
The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China
3
Sixth People’s Hospital, Qingdao 266000, China
4
Lab Animal Research Center, Hubei University of Chinese Medicine, Wuhan 430000, China
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Pathogens 2021, 10(2), 115; https://doi.org/10.3390/pathogens10020115
Submission received: 30 November 2020 / Revised: 3 January 2021 / Accepted: 15 January 2021 / Published: 23 January 2021
(This article belongs to the Special Issue Current Status and Challenges Associated with Tick-Borne Pathogens and Diseases)
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Abstract

Tickborne intracellular bacterial pathogens including Anaplasma, Coxiella burnetti, Ehrlichia, and Rickettsia cause emerging infectious diseases worldwide. PCR was used to amplify the genes of these pathogens in Haemaphysalis flava ticks collected from hedgehogs in Central China. Among 125 samples including 20 egg batches, 24 engorged females, and 81 molted male and female adult ticks, the DNA sequences and phylogenetic analysis showed that the minimum infection rate of the ticks was 4% (5/125) for A. bovis, 3.2% (4/125) for C. burnetti, 9.6%, (12/125) for E. ewingii, and 5.6% for Rickettsia including R.japonica (3.2%, 4/125) and R. raoultii (2.4%, 3/125), respectively. The prevalence of these pathogens was significantly higher in dead engorged females (83.3%, 20/24) than in eggs (5%, 1/20) and molted ticks (8.6%, 7/81). Our study indicated that H. flava ticks could be infected with multiple species of tickborne pathogens including Anaplasma, C. burnetti, Ehrlichia, and Rickettsia in Central China, and the prevalence of these pathogens was reduced during transovarial and transstadial transmission in ticks, suggesting that ticks may not be real reservoirs but only vectors for these tickborne pathogens.
Keywords: Haemaphysalis flava; hedgehogs; Anaplasma bovis; Coxiella burnetti; Ehrlichia ewingii; Rickettsia raoultii; Rickettsia japonica and China Haemaphysalis flava; hedgehogs; Anaplasma bovis; Coxiella burnetti; Ehrlichia ewingii; Rickettsia raoultii; Rickettsia japonica and China

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MDPI and ACS Style

Fang, L.-Z.; Lei, S.-C.; Yan, Z.-J.; Xiao, X.; Liu, J.-W.; Gong, X.-Q.; Yu, H.; Yu, X.-J. Detection of Multiple Intracellular Bacterial Pathogens in Haemaphysalis flava Ticks Collected from Hedgehogs in Central China. Pathogens 2021, 10, 115. https://doi.org/10.3390/pathogens10020115

AMA Style

Fang L-Z, Lei S-C, Yan Z-J, Xiao X, Liu J-W, Gong X-Q, Yu H, Yu X-J. Detection of Multiple Intracellular Bacterial Pathogens in Haemaphysalis flava Ticks Collected from Hedgehogs in Central China. Pathogens. 2021; 10(2):115. https://doi.org/10.3390/pathogens10020115

Chicago/Turabian Style

Fang, Li-Zhu, Si-Cong Lei, Zhi-Jian Yan, Xiao Xiao, Jian-Wei Liu, Xiao-Qing Gong, Hao Yu, and Xue-Jie Yu. 2021. "Detection of Multiple Intracellular Bacterial Pathogens in Haemaphysalis flava Ticks Collected from Hedgehogs in Central China" Pathogens 10, no. 2: 115. https://doi.org/10.3390/pathogens10020115

APA Style

Fang, L.-Z., Lei, S.-C., Yan, Z.-J., Xiao, X., Liu, J.-W., Gong, X.-Q., Yu, H., & Yu, X.-J. (2021). Detection of Multiple Intracellular Bacterial Pathogens in Haemaphysalis flava Ticks Collected from Hedgehogs in Central China. Pathogens, 10(2), 115. https://doi.org/10.3390/pathogens10020115

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