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Pathogens, Volume 10, Issue 2

February 2021 - 168 articles

Cover Story: Spirocerca lupi is a parasitic nematode that induces a myriad of clinical manifestations in canids and in 25% of infections leads to the formation of sarcomas. The description of the protein composition of the excretory and secretory products of S. lupi (Sl-ESP) has shed light on its possible interactions with the host environment, including migration within the host and mechanisms of immunomodulation. Despite this, the process by which S. lupi induces cancer in the dog remains poorly understood. We propose that sustained inflammatory responses in the dog tissue produced in response to the release of Sl-ESP homologous to other carcinogenic worms promote chronic inflammation and tissue damage and may also dampen effective antitumor immune responses in the malignant phase by affecting tumor antigen cross-presentation. View this paper
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Articles (168)

  • Article
  • Open Access
13 Citations
13,819 Views
14 Pages

Insight into One Health Approach: Endoparasite Infections in Captive Wildlife in Bangladesh

  • Tilak Chandra Nath,
  • Keeseon S. Eom,
  • Seongjun Choe,
  • Shahadat Hm,
  • Saiful Islam,
  • Barakaeli Abdieli Ndosi,
  • Yeseul Kang,
  • Mohammed Mebarek Bia,
  • Sunmin Kim and
  • Chatanun Eamudomkarn
  • + 3 authors

23 February 2021

Introduction: Endoparasites in captive wildlife might pose a threat to public health; however, very few studies have been conducted on this issue, and much remains to be learned, especially in limited-resource settings. This study aimed to investigat...

  • Article
  • Open Access
25 Citations
3,930 Views
7 Pages

Molecular Identification of New Cases of Human Dirofilariosis (Dirofilaria repens) in Italy

  • Simona Gabrielli,
  • Valentina Mangano,
  • Federica Furzi,
  • Alessandra Oliva,
  • Serena Vita,
  • Roberto Poscia,
  • Paolo Fazii,
  • Josephine Di Paolo,
  • Raffaella Marocco and
  • Claudio Maria Mastroianni
  • + 2 authors

23 February 2021

(1) Dirofilariosis is a vector-borne parasitic disease mainly in domestic and wild carnivores caused by Dirofilaria (Noctiella) repens, which is endemic in many countries of the Old World, and D. immitis, which has a worldwide distribution. In recent...

  • Brief Report
  • Open Access
34 Citations
4,853 Views
5 Pages

Human-to-Cat SARS-CoV-2 Transmission: Case Report and Full-Genome Sequencing from an Infected Pet and Its Owner in Northern Italy

  • Gabriele Pagani,
  • Alessia Lai,
  • Annalisa Bergna,
  • Alberto Rizzo,
  • Angelica Stranieri,
  • Alessia Giordano,
  • Saverio Paltrinieri,
  • Davide Lelli,
  • Nicola Decaro and
  • Stefano Rusconi
  • + 5 authors

23 February 2021

There have been previous reports of the human-to-cat transmission of SARS-CoV-2, but there are only a few molecular studies that have compared the whole genome of the virus in cats and their owners. We here describe a case of domestic SARS-CoV-2 tran...

  • Article
  • Open Access
9 Citations
3,466 Views
10 Pages

YM155 Inhibits NleB and SseK Arginine Glycosyltransferase Activity

  • Congrui Zhu,
  • Samir El Qaidi,
  • Peter McDonald,
  • Anuradha Roy and
  • Philip R. Hardwidge

23 February 2021

The type III secretion system effector proteins NleB and SseK are glycosyltransferases that glycosylate protein substrates on arginine residues. We conducted high-throughput screening assays on 42,498 compounds to identify NleB/SseK inhibitors. Such...

  • Review
  • Open Access
101 Citations
19,486 Views
17 Pages

22 February 2021

Streptococcus pyogenes, (colloquially named “group A streptococcus” (GAS)), is a pathogen of public health significance, infecting 18.1 million people worldwide and resulting in 500,000 deaths each year. This review identified published articles on t...

  • Article
  • Open Access
18 Citations
3,573 Views
10 Pages

Vector-Borne Pathogens with Veterinary and Public Health Significance in Melophagus ovinus (Sheep Ked) from the Qinghai-Tibet Plateau

  • Qing-Xun Zhang,
  • Ye Wang,
  • Ying Li,
  • Shu-Yi Han,
  • Bo Wang,
  • Guo-Hui Yuan,
  • Pei-Yang Zhang,
  • Zi-Wen Yang,
  • Shuang-Ling Wang and
  • Ji-Yong Chen
  • + 3 authors

22 February 2021

Melophagus ovinus (sheep ked) is a hematophagous ectoparasite that mainly parasitizes sheep. In addition to causing inflammation, wool loss, and skin damage to the animal hosts, M. ovinus also serves as a vector for a variety of pathogens and is high...

  • Article
  • Open Access
3 Citations
4,470 Views
11 Pages

Detection of Rhodococcus fascians, the Causative Agent of Lily Fasciation in South Korea

  • Joon Moh Park,
  • Jachoon Koo,
  • Se Won Kang,
  • Sung Hee Jo and
  • Jeong Mee Park

20 February 2021

Rhodococcus fascians is an important pathogen that infects various herbaceous perennials and reduces their economic value. In this study, we examined R. fascians isolates carrying a virulence gene from symptomatic lily plants grown in South Korea. Ph...

  • Article
  • Open Access
9 Citations
8,690 Views
21 Pages

An Integrated Sequencing Approach for Updating the Pseudorabies Virus Transcriptome

  • Gábor Torma,
  • Dóra Tombácz,
  • Zsolt Csabai,
  • Dániel Göbhardter,
  • Zoltán Deim,
  • Michael Snyder and
  • Zsolt Boldogkői

20 February 2021

In the last couple of years, the implementation of long-read sequencing (LRS) technologies for transcriptome profiling has uncovered an extreme complexity of viral gene expression. In this study, we carried out a systematic analysis on the pseudorabi...

  • Article
  • Open Access
6 Citations
4,379 Views
15 Pages

Non-Invasive Molecular Survey of Sarcoptic Mange in Wildlife: Diagnostic Performance in Wolf Faecal Samples Evaluated by Multi-Event Capture–Recapture Models

  • Julieta Rousseau,
  • Mónia Nakamura,
  • Helena Rio-Maior,
  • Francisco Álvares,
  • Rémi Choquet,
  • Luís Madeira de Carvalho,
  • Raquel Godinho and
  • Nuno Santos

20 February 2021

Sarcoptic mange is globally enzootic, and non-invasive methods with high diagnostic specificity for its surveillance in wildlife are lacking. We describe the molecular detection of Sarcoptes scabiei in non-invasively collected faecal samples, targeti...

  • Article
  • Open Access
11 Citations
3,342 Views
14 Pages

Akt Interacts with Usutu Virus Polymerase, and Its Activity Modulates Viral Replication

  • Laura Albentosa-González,
  • Rosario Sabariegos,
  • Armando Arias,
  • Pilar Clemente-Casares and
  • Antonio Mas

20 February 2021

Usutu virus (USUV) is a flavivirus that mainly infects wild birds through the bite of Culex mosquitoes. Recent outbreaks have been associated with an increased number of cases in humans. Despite being a growing source of public health concerns, there...

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Pathogens - ISSN 2076-0817