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Epigenomes, Volume 3, Issue 4 (December 2019) – 1 article
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Cover Story (view full-size image) A pair of monozygotic twin artificial insemination (AI) Holstein bulls in China shared identical [...] Read more. A pair of monozygotic twin artificial insemination (AI) Holstein bulls in China shared identical genetics and very similar appearances, but with discordant (Bull1 performed better than Bull2) sperm qualities and daughters’ fertility performance (~6000 daughters per bull). We wondered whether epigenetic modifications in their sperm cells contributed to the differences. By investigating the DNA methylomes and transcriptomes of the sperm cells, we observed higher global sperm methylation levels in Bull1 than in Bull2 and highlighted several fertility-related genes that were potentially epigenetically regulated. The results provided new insights into the influences of AI bull sperm methylomes on offspring fertility. View this paper.