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Journal of Personalized Medicine, Volume 13, Issue 8

August 2023 - 99 articles

Cover Story: Although gBRCA status may inform breast cancer treatment decisions, not all patients who meet the guideline criteria receive gBRCA testing. To better understand real and perceived barriers, a first of its kind survey was conducted across various stakeholders (n = 430) including oncologists, surgeons, nurses, physician assistants, payers, and patients. The study found that while payers claim to cover gBRCA testing, they place controls on testing reimbursement due to the lack of proper eligibility documentation by clinicians and perceived testing overutilization. As a result, clinicians experience payer pushback, leading to reimbursement limitations, denials and hesitancy to test some patients. Encouraging all stakeholders to address this disconnect may increase testing rates for guideline-eligible patients and could lead to improved patient care. View this paper
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Articles (99)

  • Article
  • Open Access
2 Citations
1,804 Views
11 Pages

Acute Changes on Left Atrial Function during Incremental Exercise in Patients with Heart Failure with Mildly Reduced Ejection Fraction: A Case-Control Study

  • Marco Alfonso Perrone,
  • Ferdinando Iellamo,
  • Valentino D’Antoni,
  • Alessandro Gismondi,
  • Deborah Di Biasio,
  • Sara Vadalà,
  • Giuseppe Marazzi,
  • Valentina Morsella,
  • Maurizio Volterrani and
  • Giuseppe Caminiti

18 August 2023

Background: the aim of this study was to assess acute changes in left atrial (LA) function during incremental aerobic exercise in patients with heart failure with mildly reduced ejection fraction (HFmrEF) in comparison to healthy subjects (HS). Metho...

  • Article
  • Open Access
2 Citations
2,393 Views
10 Pages

The Rising Problem of Hip Fractures in Geriatric Patients—Analysis of Surgical Influences on the Outcome

  • Julian Krickl,
  • Till Ittermann,
  • Andreas Thannheimer,
  • Wolfgang Schmidt,
  • Maximilian Willauschus,
  • Johannes Ruether,
  • Kim Loose,
  • Markus Gesslein and
  • Michael Millrose

17 August 2023

Background: Hip fractures in geriatric patients often have a poor outcome in terms of mortality, mobility as well as independence. Different surgical influence factors are known that improve the outcome. Methods: In this observational cohort study, 2...

  • Article
  • Open Access
5 Citations
2,634 Views
17 Pages

Comprehensive Molecular Evaluation of HNF-1 Alpha, miR-27a, and miR-146 Gene Variants and Their Link with Predisposition and Progression in Type 2 Diabetes Patients

  • Rashid Mir,
  • Imadeldin Elfaki,
  • M. E. Elangeeb,
  • Mamdoh S. Moawadh,
  • Faris Jamal Tayeb,
  • Jameel Barnawi,
  • Ibrahim Altedlawi Albalawi,
  • Amnah A. Alharbi,
  • Marwan H. Alhelali and
  • Basim S. O. Alsaedi

17 August 2023

Background: Type 2 diabetes (T2D) is a metabolic condition induced by insulin resistance and pancreatic beta cell dysfunction. MicroRNAs (miRNAs) have biological significance because they regulate processes such as the molecular signaling pathways in...

  • Protocol
  • Open Access
6 Citations
5,248 Views
14 Pages

Efficacy of Personalized Foot Orthoses in Children with Flexible Flat Foot: Protocol for a Randomized Controlled Trial

  • Cristina Molina-García,
  • Andrés Reinoso-Cobo,
  • Jonathan Cortés-Martín,
  • Eva Lopezosa-Reca,
  • Ana Marchena-Rodriguez,
  • George Banwell and
  • Laura Ramos-Petersen

17 August 2023

Pediatric flat foot (PFF) is a very frequent entity and a common concern for parents and health professionals. There is no established definition, diagnostic method, or clear treatment approach. There are multiple conservative and surgical treatments...

  • Review
  • Open Access
36 Citations
4,899 Views
14 Pages

Artificial Intelligence-Based Methods for Precision Cardiovascular Medicine

  • Farida Mohsen,
  • Balqees Al-Saadi,
  • Nima Abdi,
  • Sulaiman Khan and
  • Zubair Shah

16 August 2023

Precision medicine has the potential to revolutionize the way cardiovascular diseases are diagnosed, predicted, and treated by tailoring treatment strategies to the individual characteristics of each patient. Artificial intelligence (AI) has recently...

  • Article
  • Open Access
1 Citations
1,880 Views
18 Pages

Lessons Learned from the COVID-19 Pandemic: A Survey-Based Study on a Sample of Italian Physicians’ Opinions on Telemedicine

  • Pamela Tozzo,
  • Arianna Delicati,
  • Beatrice Marcante,
  • Dolores Catelan and
  • Luciana Caenazzo

16 August 2023

Telemedicine was born out of the need to ensure clinical evaluation and personal care regardless of the physical presence of the healthcare professional nearby. Information technologies have been vital during the COVID-19 pandemic to ensure medical c...

  • Article
  • Open Access
2 Citations
2,547 Views
12 Pages

16 August 2023

Injury can occur during intraoperative transcranial motor-evoked potential (MEP) monitoring caused by patient movement related to insufficient neuromuscular blocking agent use. Here, we evaluated the incidence of unacceptable movements in patients un...

  • Article
  • Open Access
1 Citations
3,141 Views
12 Pages

The Influence of Cardiac Arrest Floor-Level Location within a Building on Survival Outcomes

  • Chiwon Ahn,
  • Young Taeck Oh,
  • Yeonkyung Park,
  • Jae Hwan Kim,
  • Sojune Hwang and
  • Moonho Won

16 August 2023

This nationwide, population-based observational study investigated the association between the floor level of out-of-hospital cardiac arrest (OHCA) incidence and survival outcomes in South Korea, notable for its significant high-rise apartment living...

  • Article
  • Open Access
27 Citations
7,863 Views
13 Pages

The Role of Oxidative Stress in Infertility

  • Ioana Zaha,
  • Mariana Muresan,
  • Camelia Tulcan,
  • Anca Huniadi,
  • Petronela Naghi,
  • Mircea Sandor,
  • Roberta Tripon,
  • Cristina Gaspar,
  • Major Klaudia-Melinda and
  • Liliana Sachelarie
  • + 1 author

15 August 2023

(1) Background: Oxidative stress markers in the follicular fluid and serum of the patient with IVF results (number of fertilized oocytes, number of embryos, cumulative pregnancy rate) are important in establishing the causes of infertility. (2) Metho...

  • Review
  • Open Access
7 Citations
7,816 Views
26 Pages

Charting the Path: Navigating Embryonic Development to Potentially Safeguard against Congenital Heart Defects

  • José Bragança,
  • Rute Pinto,
  • Bárbara Silva,
  • Nuno Marques,
  • Helena S. Leitão and
  • Mónica T. Fernandes

15 August 2023

Congenital heart diseases (CHDs) are structural or functional defects present at birth due to improper heart development. Current therapeutic approaches to treating severe CHDs are primarily palliative surgical interventions during the peri- or prena...

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J. Pers. Med. - ISSN 2075-4426