You are currently viewing a new version of our website. To view the old version click .

Journal of Personalized Medicine, Volume 13, Issue 2

February 2023 - 214 articles

Cover Story: Many computational problems used in the analysis of single-cell transcriptomic data are inherently multi-objective and challenging to solve. Genetic algorithms, inspired by the process of biological evolution, are well-suited for multi-objective optimization problems and can produce an ensemble of solutions, known as Pareto optimal solutions. A recent study demonstrated that a multi-objective genetic algorithm (MOGA) can successfully cluster single-cell transcriptomes of synthetic and experimental datasets, outperforming existing single-objective clustering methods. Despite its stochastic nature, MOGA produces reproducible and stable clustering results. The running times of MOGA can be improved by code parallelization and predicted using a random forest model, making it practical for the clustering of large scRNA-seq datasets. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (214)

  • Article
  • Open Access
5 Citations
5,758 Views
11 Pages

Quadriceps Tendon Ruptures in Middle-Aged to Older Patients: A Retrospective Study on the Preoperative MRI Injury Patterns and Mid-Term Patient-Reported Outcome Measures

  • Kim Loose,
  • Justus Rudolph,
  • Martin Schlösser,
  • Maximilian Willauschus,
  • Johannes Rüther,
  • Philipp Schuster,
  • Hermann Josef Bail,
  • Michael Millrose and
  • Markus Geßlein

18 February 2023

(1) Quadriceps tendon rupture (QTR) is a rare pathology, usually occurring in elderly patients with comorbidities, requiring surgical therapy. The aim of this study was to analyze rupture patterns and concomitant injuries using preoperative magnetic...

  • Article
  • Open Access
4 Citations
3,567 Views
12 Pages

Dynamic Biobanking for Advancing Breast Cancer Research

  • Maryam Abdollahyan,
  • Emanuela Gadaleta,
  • Millahat Asif,
  • Jorge Oscanoa,
  • Rachel Barrow-McGee,
  • Samantha Jones,
  • Louise J Jones and
  • Claude Chelala

18 February 2023

Longitudinal patient biospecimens and data advance breast cancer research through enabling precision medicine approaches for identifying risk, early diagnosis, improved disease management and targeted therapy. Cancer biobanks must evolve to provide n...

  • Article
  • Open Access
3 Citations
1,900 Views
12 Pages

18 February 2023

Purpose: To propose a novel, radiation-free method for postoperative three-dimensional (3D) position analysis of dental implants based on the dynamic navigation system (DNS) and evaluate its accuracy in vitro. Methods: A total of 60 implants were dig...

  • Feature Paper
  • Review
  • Open Access
10 Citations
3,066 Views
12 Pages

Effect of Radio-Chemotherapy on PD-L1 Immunohistochemical Expression in Head and Neck Squamous Cell Carcinoma

  • Ilaria Girolami,
  • Stefano Marletta,
  • Vincenzo Fiorentino,
  • Simonetta Battocchio,
  • Bruna Cerbelli,
  • Barbara Fiamengo,
  • Clara Gerosa,
  • Andrea Gianatti,
  • Luca Morelli and
  • Giulio Riva
  • + 8 authors

18 February 2023

Background: Programmed death-ligand 1 (PD-L1) checkpoint inhibitors represent a mainstay of therapy in head and neck squamous cell cancer (HNSCC). However, little is known about the influence of combined therapy on PD-L1 expression. The study aims to...

  • Article
  • Open Access
2,038 Views
10 Pages

18 February 2023

Regarding attempts to find de-escalation methods of treatment for patients with HPV16-positive squamous cell carcinoma of the oropharynx (OPSCC), there is an urgent need to identify new prognostic factors which allow physicians to differentiate the p...

  • Article
  • Open Access
5 Citations
2,866 Views
22 Pages

18 February 2023

Increasing evidence has revealed the promise of mRNA-type cancer vaccines as a new direction for cancer immune treatment in several solid tumors, however, its application in papillary renal cell carcinoma (PRCC) remains unclear. The purpose of this s...

  • Opinion
  • Open Access
2 Citations
2,856 Views
7 Pages

A Practical Assessment of the Postoperative Management in Lung Cancer Surgery

  • Luca Bertolaccini,
  • Shehab Mohamed,
  • Clarissa Uslenghi,
  • Matteo Chiari,
  • Lara Girelli,
  • Giorgio Lo Iacono and
  • Lorenzo Spaggiari

18 February 2023

Postoperative management after major and minor thoracic surgeries is crucial for patient recovery and can be challenging. Major thoracic surgeries, such as extensive pulmonary resections, especially in patients with poor health status, may require in...

  • Perspective
  • Open Access
17 Citations
3,134 Views
9 Pages

17 February 2023

(1) Background: Magnesium-based implants use has become a research focus in recent years. Radiolucent areas around inserted screws are still worrisome. The objective of this study was to investigate the first 18 patients treated using MAGNEZIX® C...

  • Article
  • Open Access
2 Citations
2,603 Views
12 Pages

ABO Blood Groups as a Disease Marker to Predict Atrial Fibrillation Recurrence after Catheter Ablation

  • Shin-Huei Liu,
  • Chheng Chhay,
  • Yu-Feng Hu,
  • Yenn-Jiang Lin,
  • Shih-Lin Chang,
  • Li-Wei Lo,
  • Fa-Po Chung,
  • Ta-Chuan Tuan,
  • Tze-Fan Chao and
  • Jo-Nan Liao
  • + 7 authors

17 February 2023

Chronic inflammation harbors a vulnerable substrate for atrial fibrillation (AF) recurrence after catheter ablation. However, whether the ABO blood types are associated with AF recurrence after catheter ablation is unknown. A total of 2106 AF patient...

  • Feature Paper
  • Article
  • Open Access
1 Citations
3,533 Views
16 Pages

Identification of the Magna Radicular Artery Entry Foramen and Adamkiewicz System: Patient Selection for Open versus Full-Endoscopic Thoracic Spinal Decompression Surgery

  • Roth Antonio Vargas,
  • Eduardo Miquelino De Olinveira,
  • Marco Moscatelli,
  • Jorge Felipe Ramírez León,
  • Morgan P. Lorio,
  • Rossano Kepler Fiorelli,
  • Albert E. Telfeian,
  • Ernest Braxton,
  • Michael Song and
  • Kai-Uwe Lewandrowski

17 February 2023

Background: Casually cauterizing the radicular magna during routine thoracic discectomy may have dire consequences. Methods: We performed a retrospective observational cohort study on patients scheduled for decompression of symptomatic thoracic herni...

of 22

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
J. Pers. Med. - ISSN 2075-4426