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Diagnostics, Volume 14, Issue 12

June-2 2024 - 107 articles

Cover Story: This study presents the first-ever utilization of anti-RNase aptamers, specifically chosen to target and inactivate RNases in Xtract-Free™, a next-generation sample collection and transport medium. The incorporation of aptamers for RNase inactivation in Xtract-Free™ provides the following advantages: (1) it offers a safe and eco-friendly alternative for both molecular and lateral flow diagnostic tests, eliminating the requirement for nucleic acid extraction prior to PCR, (2) it ensures the preservation and stabilization of RNA for PCR and other RNA-related genomic applications such as RNA-Seq and transcriptome analysis; (3) it broadens the range of collection media beyond traditional viral transport media and caustic molecular transport media, catering to the increasing demand for a safe medium suitable for point-of-care, self-collection, return mail, and home collection purposes. View this paper
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Articles (107)

  • Article
  • Open Access
8 Citations
2,701 Views
14 Pages

Computed tomography (CT) scans have recently emerged as a major technique for the fast diagnosis of lung diseases via image classification techniques. In this study, we propose a method for the diagnosis of COVID-19 disease with improved accuracy by...

  • Article
  • Open Access
2,374 Views
11 Pages

Comparison of Small Blood Vessel Diameter with Intravascular Ultrasound and Coronary Angiography for Guidance of Percutaneous Coronary Intervention

  • Sergio A. Zuñiga-Mendoza,
  • Emanuel Zayas-Diaz,
  • Victoria R. Armenta-Velazquez,
  • Ana A. Silva-Baeza,
  • Juan J. Beltran-Ochoa,
  • Misael A. Medina-Servin and
  • Maria G. Zavala-Cerna

Major cardiovascular events (MACEs) are a cause of major mortality worldwide. The narrowing and blockage of coronary arteries with atherosclerotic plaques are diagnosed and treated with percutaneous coronary intervention (PCI). During this procedure,...

  • Review
  • Open Access
10 Citations
3,568 Views
15 Pages

Presepsin in Critical Illness: Current Knowledge and Future Perspectives

  • Paolo Formenti,
  • Miriam Gotti,
  • Francesca Palmieri,
  • Stefano Pastori,
  • Vincenzo Roccaforte,
  • Alessandro Menozzi,
  • Andrea Galimberti,
  • Michele Umbrello,
  • Giovanni Sabbatini and
  • Angelo Pezzi

The accurate identification of infections is critical for effective treatment in intensive care units (ICUs), yet current diagnostic methods face limitations in sensitivity and specificity, alongside cost and accessibility issues. Consequently, there...

  • Article
  • Open Access
1 Citations
2,107 Views
10 Pages

The Association between Echocardiographic Parameters of Heart Failure with Preserved Ejection Fraction and Fluid Status Biomarkers in Hemodialysis Patients

  • Mariusz Lupa,
  • Agnieszka Pardała,
  • Anna Bednarek,
  • Jolanta Mrochem-Kwarciak,
  • Regina Deja,
  • Katarzyna Mizia-Stec and
  • Aureliusz Kolonko

Overhydration and cardiac function abnormalities are common in hemodialysis patients. The association of N-terminal prohormone for brain natriuretic peptide (NT-proBNP) and other fluid status biomarkers with echocardiographic parameters of heart fail...

  • Article
  • Open Access
4 Citations
2,879 Views
23 Pages

Lung cancer is a prevalent malignancy associated with a high mortality rate, with a 5-year relative survival rate of 23%. Traditional survival analysis methods, reliant on clinician judgment, may lack accuracy due to their subjective nature. Conseque...

  • Article
  • Open Access
9 Citations
3,244 Views
44 Pages

Enhancing Clinical Validation for Early Cardiovascular Disease Prediction through Simulation, AI, and Web Technology

  • Md Abu Sufian,
  • Wahiba Hamzi,
  • Sadia Zaman,
  • Lujain Alsadder,
  • Boumediene Hamzi,
  • Jayasree Varadarajan and
  • Md Abul Kalam Azad

Cardiovascular diseases (CVDs) remain a major global health challenge and a leading cause of mortality, highlighting the need for improved predictive models. We introduce an innovative agent-based dynamic simulation technique that enhances our AI mod...

  • Article
  • Open Access
1 Citations
1,937 Views
12 Pages

In this single-center, retrospective, observational study, we aimed to assess the severity at which patients with trauma tend to develop metabolic disturbances that worsen their Controlling Nutritional Status (CONUT) scores. Participants were general...

  • Article
  • Open Access
2 Citations
2,140 Views
9 Pages

Macular Ischemia Changes in Patients with Diabetic Macular Edema Treated with Aflibercept and Ranibizumab

  • Dimitrios Maris,
  • Anna Dastiridou,
  • Maria Kotoula,
  • Aikaterini Karathanou,
  • Evangelia E. Tsironi,
  • Alexandra Bargiota and
  • Sofia Androudi

Τhis study aims to assess changes in the fovea avascular zone (FAZ) in treatment naïve patients receiving aflibercept or ranibizumab injections for diabetic macular edema (DME). Best corrected visual acuity (BCVA) testing, OCT, and OCT-angio...

  • Review
  • Open Access
1 Citations
1,862 Views
13 Pages

Speckle-Tracking Echocardiography in Right Ventricular Function of Clinically Well Patients with Heart Transplantation

  • Xiang Ji,
  • Junmin Zhang,
  • Yuji Xie,
  • Wenyuan Wang,
  • Yiwei Zhang,
  • Mingxing Xie and
  • Li Zhang

Heart transplantation (HT) is the mainstream therapy for end-stage heart disease. However, the cardiac graft function can be affected by several factors. It is important to monitor HT patients for signs of graft dysfunction. Transthoracic echocardiog...

  • Article
  • Open Access
7 Citations
2,081 Views
11 Pages

Ischemic stroke is a leading cause of mortality and disability. The relationships of heart rate variability (HRV) and stroke-related factors with mortality and functional outcome are complex and not fully understood. Understanding these relationships...

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Diagnostics - ISSN 2075-4418