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Diagnostics, Volume 14, Issue 12

2024 June-2 - 107 articles

Cover Story: This study presents the first-ever utilization of anti-RNase aptamers, specifically chosen to target and inactivate RNases in Xtract-Free™, a next-generation sample collection and transport medium. The incorporation of aptamers for RNase inactivation in Xtract-Free™ provides the following advantages: (1) it offers a safe and eco-friendly alternative for both molecular and lateral flow diagnostic tests, eliminating the requirement for nucleic acid extraction prior to PCR, (2) it ensures the preservation and stabilization of RNA for PCR and other RNA-related genomic applications such as RNA-Seq and transcriptome analysis; (3) it broadens the range of collection media beyond traditional viral transport media and caustic molecular transport media, catering to the increasing demand for a safe medium suitable for point-of-care, self-collection, return mail, and home collection purposes. View this paper
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Articles (107)

  • Article
  • Open Access
12 Citations
3,332 Views
14 Pages

Computed tomography (CT) scans have recently emerged as a major technique for the fast diagnosis of lung diseases via image classification techniques. In this study, we propose a method for the diagnosis of COVID-19 disease with improved accuracy by...

(This article belongs to the Topic AI in Medical Imaging and Image Processing)
  • Article
  • Open Access
3,075 Views
11 Pages

Comparison of Small Blood Vessel Diameter with Intravascular Ultrasound and Coronary Angiography for Guidance of Percutaneous Coronary Intervention

  • Sergio A. Zuñiga-Mendoza,
  • Emanuel Zayas-Diaz,
  • Victoria R. Armenta-Velazquez,
  • Ana A. Silva-Baeza,
  • Juan J. Beltran-Ochoa,
  • Misael A. Medina-Servin and
  • Maria G. Zavala-Cerna

Major cardiovascular events (MACEs) are a cause of major mortality worldwide. The narrowing and blockage of coronary arteries with atherosclerotic plaques are diagnosed and treated with percutaneous coronary intervention (PCI). During this procedure,...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Review
  • Open Access
19 Citations
5,149 Views
15 Pages

Presepsin in Critical Illness: Current Knowledge and Future Perspectives

  • Paolo Formenti,
  • Miriam Gotti,
  • Francesca Palmieri,
  • Stefano Pastori,
  • Vincenzo Roccaforte,
  • Alessandro Menozzi,
  • Andrea Galimberti,
  • Michele Umbrello,
  • Giovanni Sabbatini and
  • Angelo Pezzi

The accurate identification of infections is critical for effective treatment in intensive care units (ICUs), yet current diagnostic methods face limitations in sensitivity and specificity, alongside cost and accessibility issues. Consequently, there...

(This article belongs to the Section Diagnostic Microbiology and Infectious Disease)
  • Article
  • Open Access
4 Citations
2,730 Views
10 Pages

The Association between Echocardiographic Parameters of Heart Failure with Preserved Ejection Fraction and Fluid Status Biomarkers in Hemodialysis Patients

  • Mariusz Lupa,
  • Agnieszka Pardała,
  • Anna Bednarek,
  • Jolanta Mrochem-Kwarciak,
  • Regina Deja,
  • Katarzyna Mizia-Stec and
  • Aureliusz Kolonko

Overhydration and cardiac function abnormalities are common in hemodialysis patients. The association of N-terminal prohormone for brain natriuretic peptide (NT-proBNP) and other fluid status biomarkers with echocardiographic parameters of heart fail...

(This article belongs to the Special Issue Advances in Nephrology)
  • Article
  • Open Access
8 Citations
3,790 Views
23 Pages

Lung cancer is a prevalent malignancy associated with a high mortality rate, with a 5-year relative survival rate of 23%. Traditional survival analysis methods, reliant on clinician judgment, may lack accuracy due to their subjective nature. Conseque...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Article
  • Open Access
17 Citations
4,240 Views
44 Pages

Enhancing Clinical Validation for Early Cardiovascular Disease Prediction through Simulation, AI, and Web Technology

  • Md Abu Sufian,
  • Wahiba Hamzi,
  • Sadia Zaman,
  • Lujain Alsadder,
  • Boumediene Hamzi,
  • Jayasree Varadarajan and
  • Md Abul Kalam Azad

Cardiovascular diseases (CVDs) remain a major global health challenge and a leading cause of mortality, highlighting the need for improved predictive models. We introduce an innovative agent-based dynamic simulation technique that enhances our AI mod...

(This article belongs to the Special Issue Artificial Intelligence in Cardiology Diagnosis )
  • Article
  • Open Access
1 Citations
2,453 Views
12 Pages

In this single-center, retrospective, observational study, we aimed to assess the severity at which patients with trauma tend to develop metabolic disturbances that worsen their Controlling Nutritional Status (CONUT) scores. Participants were general...

(This article belongs to the Special Issue ICU Disease Diagnosis)
  • Article
  • Open Access
5 Citations
2,926 Views
9 Pages

Macular Ischemia Changes in Patients with Diabetic Macular Edema Treated with Aflibercept and Ranibizumab

  • Dimitrios Maris,
  • Anna Dastiridou,
  • Maria Kotoula,
  • Aikaterini Karathanou,
  • Evangelia E. Tsironi,
  • Alexandra Bargiota and
  • Sofia Androudi

Τhis study aims to assess changes in the fovea avascular zone (FAZ) in treatment naïve patients receiving aflibercept or ranibizumab injections for diabetic macular edema (DME). Best corrected visual acuity (BCVA) testing, OCT, and OCT-angio...

(This article belongs to the Special Issue Optical Coherence Tomography in Diagnosis of Ophthalmology Disease)
  • Review
  • Open Access
2 Citations
2,398 Views
13 Pages

Speckle-Tracking Echocardiography in Right Ventricular Function of Clinically Well Patients with Heart Transplantation

  • Xiang Ji,
  • Junmin Zhang,
  • Yuji Xie,
  • Wenyuan Wang,
  • Yiwei Zhang,
  • Mingxing Xie and
  • Li Zhang

Heart transplantation (HT) is the mainstream therapy for end-stage heart disease. However, the cardiac graft function can be affected by several factors. It is important to monitor HT patients for signs of graft dysfunction. Transthoracic echocardiog...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
11 Citations
2,640 Views
11 Pages

Ischemic stroke is a leading cause of mortality and disability. The relationships of heart rate variability (HRV) and stroke-related factors with mortality and functional outcome are complex and not fully understood. Understanding these relationships...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Review
  • Open Access
6 Citations
4,585 Views
37 Pages

Endocrine Petrified Ear: Associated Endocrine Conditions in Auricular Calcification/Ossification (A Sample-Focused Analysis)

  • Ana Valea,
  • Claudiu Nistor,
  • Mihai-Lucian Ciobica,
  • Oana-Claudia Sima and
  • Mara Carsote

Petrified ear (PE), an exceptional entity, stands for the calcification ± ossification of auricular cartilage (CAC/OAC); its pathogenic traits are still an open matter. Endocrine panel represents one of the most important; yet, no standard pro...

(This article belongs to the Special Issue Biomarkers: Diagnostic Indicators for Human Ailments)
  • Article
  • Open Access
11 Citations
3,980 Views
11 Pages

Long-Term Results of Surgical Treatment for Popliteal Artery Entrapment Syndrome

  • Wassim Mansour,
  • Francesca Miceli,
  • Alessia Di Girolamo,
  • Ada Dajci,
  • Antonio Marzano,
  • Rocco Cangiano,
  • Marta Ascione and
  • Luca di Marzo

Introduction: Popliteal artery entrapment syndrome (PAES) is a rare disease of the lower limbs, mainly affecting young patients, due to extrinsic compression of the neurovascular bundle at the popliteal fossa. The aim of this study was to describe ou...

(This article belongs to the Special Issue Recent Advances in the Diagnosis and Treatment of Vascular Diseases)
  • Article
  • Open Access
2,909 Views
14 Pages

MRI-Derived Dural Sac and Lumbar Vertebrae 3D Volumetry Has Potential for Detection of Marfan Syndrome

  • Omar Naas,
  • Tobias Norajitra,
  • Christian Lückerath,
  • Matthias A. Fink,
  • Klaus Maier-Hein,
  • Hans-Ulrich Kauczor and
  • Fabian Rengier

Purpose: To assess the feasibility and diagnostic accuracy of MRI-derived 3D volumetry of lower lumbar vertebrae and dural sac segments using shape-based machine learning for the detection of Marfan syndrome (MFS) compared with dural sac diameter rat...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Review
  • Open Access
7 Citations
4,911 Views
11 Pages

The liver, given its role as the central metabolic organ, is involved in many inherited metabolic disorders, including lysosomal storage diseases (LSDs). The aim of this manuscript was to provide a comprehensive overview on liver involvement in LSDs,...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Review
  • Open Access
1 Citations
3,371 Views
43 Pages

Beyond the challenges of diagnosis, complexity measurement in clients with mental illness is an important but under-recognized area. Accurate and appropriate psychiatric diagnoses are essential, and further complexity measurements could contribute to...

(This article belongs to the Special Issue Advances in Mental Health Diagnosis and Screening)
  • Review
  • Open Access
3 Citations
3,378 Views
11 Pages

Giant Myxofibrosarcoma in the Lower Limb: An Overview of Diagnostic and Clinical Management

  • Răzvan Ene,
  • Alexandru Lisias Dimitriu,
  • Ileana Peride,
  • Mirela Țigliș,
  • Elisa Georgiana Popescu,
  • Eduard Cătălin Georgescu,
  • Tiberiu Paul Neagu,
  • Ionel Alexandru Checherita and
  • Andrei Niculae

Myxofibrosarcoma (MFS), an aggressive soft tissue sarcoma, is one of the undifferentiated pleomorphic sarcomas; it has a low incidence, affecting people in the sixth to eighth decades of life. It usually involves the extremities and is painless with...

(This article belongs to the Special Issue Soft Tissue Sarcoma: From Diagnosis to Prognosis)
  • Article
  • Open Access
25 Citations
4,733 Views
26 Pages

Revolutionizing Chronic Heart Disease Management: The Role of IoT-Based Ambulatory Blood Pressure Monitoring System

  • Yogesh Kale,
  • Shubhangi Rathkanthiwar,
  • Ganesh Yenurkar,
  • Sandip Mal,
  • Vincent O. Nyangaresi,
  • Shailesh Kamble,
  • Lalit Damahe and
  • Nandkishor Bankar

Chronic heart disease (CHD) is a widespread and persistent health challenge that demands immediate attention. Early detection and accurate diagnosis are essential for effective treatment and management of this condition. To overcome this difficulty,...

(This article belongs to the Special Issue AI-Driven Diagnostics: Transforming Healthcare from Data to Clinical Decisions)
  • Article
  • Open Access
3 Citations
6,549 Views
23 Pages

Background: Accurate prognostic prediction is crucial for managing Idiopathic Sudden Sensorineural Hearing Loss (ISSHL). Previous studies developing ISSHL prognosis models often overlooked individual variability in hearing damage by relying on fixed...

(This article belongs to the Special Issue Machine Learning in Precise and Personalized Diagnosis)
  • Article
  • Open Access
3 Citations
2,349 Views
9 Pages

Involvement of Sclera in Lattice Retinal Degeneration: An Optical Coherence Tomography Study

  • Dmitrii S. Maltsev,
  • Alexey N. Kulikov,
  • Maria A. Burnasheva,
  • Alexander S. Vasiliev,
  • Yana A. Kalinicheva and
  • Alina A. Kazak

The aim of the study was to evaluate the local status of the sclera in lattice retinal degeneration. Patients with lattice degeneration, snail-track degeneration, or horseshoe retinal breaks were included. One lesion of a single eye in each patient w...

(This article belongs to the Special Issue Vitreo-Retinal Disorders: Pathophysiology and Diagnostic Imaging)
  • Article
  • Open Access
9 Citations
3,633 Views
16 Pages

Unilateral cleft lip and palate (UCLP) nasal deformity impacts airflow patterns and pressure distribution, leading to nasal breathing difficulties. This study aims to create an integrated approach using computer-aided design (CAD) and computational f...

(This article belongs to the Special Issue Craniofacial Imaging in Clinical Practice: Techniques, Innovations and Clinical Applications)
  • Article
  • Open Access
2 Citations
1,698 Views
11 Pages

Microparticles in Human Perspiration as an Inflammatory Response Index

  • Zuha Imtiyaz,
  • Veena M. Bhopale,
  • Awadhesh K. Arya,
  • Abid R. Bhat and
  • Stephen R. Thom

A blood component analysis is an early step for evaluating inflammatory disorders, but it can be unfeasible in some settings. This pilot study assessed whether extracellular vesicle (EV) changes in perspiration are parallel to those occurring in bloo...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
1 Citations
2,288 Views
12 Pages

A Comparison of the Clinical Characteristics of Short-, Mid-, and Long-Term Mortality in Patients Attended by the Emergency Medical Services: An Observational Study

  • Rodrigo Enriquez de Salamanca Gambara,
  • Ancor Sanz-García,
  • Carlos del Pozo Vegas,
  • Raúl López-Izquierdo,
  • Irene Sánchez Soberón,
  • Juan F. Delgado Benito,
  • Raquel Martínez Diaz,
  • Cristina Mazas Pérez-Oleaga,
  • Nohora Milena Martínez López and
  • Francisco Martín-Rodríguez
  • + 1 author

Aim: The development of predictive models for patients treated by emergency medical services (EMS) is on the rise in the emergency field. However, how these models evolve over time has not been studied. The objective of the present work is to compare...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
10 Citations
4,314 Views
14 Pages

68Ga-PSMA PET/CT in Recurrent Prostate Cancer after Radical Prostatectomy Using PSMA-RADS Version 2.0

  • Gabriele Masselli,
  • Saadi Sollaku,
  • Cristina De Angelis,
  • Elisabetta Polettini,
  • Gianfranco Gualdi and
  • Emanuele Casciani

Background: 68Ga-PSMA PET/CT is superior to standard-of-care imaging for detecting regional and distant metastatic recurrent prostate cancer. The objective of our study was to evaluate the performance of 68Ga-PSMAPET/CT in our patient population, usi...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
3 Citations
3,010 Views
20 Pages

Application of a Machine Learning-Based Classification Approach for Developing Host Protein Diagnostic Models for Infectious Disease

  • Thomas F. Scherr,
  • Christina E. Douglas,
  • Kurt E. Schaecher,
  • Randal J. Schoepp,
  • Keersten M. Ricks and
  • Charles J. Shoemaker

In recent years, infectious disease diagnosis has increasingly turned to host-centered approaches as a complement to pathogen-directed ones. The former, however, typically requires the interpretation of complex multiple biomarker datasets to arrive a...

(This article belongs to the Section Diagnostic Microbiology and Infectious Disease)
  • Review
  • Open Access
19 Citations
13,101 Views
20 Pages

Biochemical Markers for Neuroendocrine Tumors: Traditional Circulating Markers and Recent Development—A Comprehensive Review

  • Marianna Franchina,
  • Federica Cavalcoli,
  • Olga Falco,
  • Marta La Milia,
  • Alessandra Elvevi and
  • Sara Massironi

Neuroendocrine neoplasms (NENs) are a heterogeneous group of neoplasms presenting unique challenges in diagnosis and management. Traditional markers such as chromogranin A (CgA), pancreatic polypeptide (PP), and neuron-specific enolase (NSE) have lim...

(This article belongs to the Special Issue Diagnosis and Management of Neuroendocrine Tumors)
  • Brief Report
  • Open Access
6 Citations
1,856 Views
7 Pages

Modified “C” Haptic Intraocular Lens Orientation and Negative Dysphotopsia

  • Valeria Cuevas-Lozano,
  • Rosario Gulias-Cañizo and
  • Oscar Guerrero-Berger

Phacoemulsification is the standard of care in cataract surgery in the developed world, with patients having high expectations regarding visual results. Postoperative dissatisfaction due to negative dysphotopsia (ND) ranges from rare to very frequent...

(This article belongs to the Special Issue Advances in Diagnostics of the Cornea, Cataract and Refractive Surgery)
  • Review
  • Open Access
9 Citations
7,979 Views
23 Pages

Purpose of Review: This review aims to provide a comprehensive overview of the diagnosis of brain death/death by neurologic criteria (BD/DNC) by emphasizing the clinical criteria established by the American Academy of Neurology (AAN) in light of thei...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
3 Citations
4,859 Views
14 Pages

Comparative Analysis of Lymphocyte Populations in Post-COVID-19 Condition and COVID-19 Convalescent Individuals

  • Luisa Berger,
  • Johannes Wolf,
  • Sven Kalbitz,
  • Nils Kellner,
  • Christoph Lübbert and
  • Stephan Borte

Reduced lymphocyte counts in peripheral blood are one of the most common observations in acute phases of viral infections. Although many studies have already examined the impact of immune (dys)regulation during SARS-CoV-2 infection, there are still u...

(This article belongs to the Topic Post COVID-19: Latest Advances, Challenges and Methodologies)
  • Article
  • Open Access
21 Citations
3,034 Views
16 Pages

Glaucoma Detection through a Novel Hyperspectral Imaging Band Selection and Vision Transformer Integration

  • Ching-Yu Wang,
  • Hong-Thai Nguyen,
  • Wen-Shuang Fan,
  • Jiann-Hwa Lue,
  • Penchun Saenprasarn,
  • Meei-Maan Chen,
  • Shuan-Yu Huang,
  • Fen-Chi Lin and
  • Hsiang-Chen Wang

Conventional diagnostic methods for glaucoma primarily rely on non-dynamic fundus images and often analyze features such as the optic cup-to-disc ratio and abnormalities in specific retinal locations like the macula and fovea. However, hyperspectral...

(This article belongs to the Special Issue Artificial Intelligence in Eye Disease, 3rd Edition)
  • Article
  • Open Access
11 Citations
3,652 Views
16 Pages

A Machine Learning Model for the Prediction of COVID-19 Severity Using RNA-Seq, Clinical, and Co-Morbidity Data

  • Sahil Sethi,
  • Sushil Shakyawar,
  • Athreya S. Reddy,
  • Jai Chand Patel and
  • Chittibabu Guda

The premise for this study emanated from the need to understand SARS-CoV-2 infections at the molecular level and to develop predictive tools for managing COVID-19 severity. With the varied clinical outcomes observed among infected individuals, creati...

(This article belongs to the Special Issue Artificial Intelligence in Clinical Decision Support)
  • Article
  • Open Access
4 Citations
2,232 Views
11 Pages

Diagnostic Performance of Plasma SP-D, KL-6, and CC16 in Acutely Hospitalised Patients Suspected of Having Community-Acquired Pneumonia—A Diagnostic Accuracy Study

  • Anne Heltborg,
  • Christian B. Mogensen,
  • Eline S. Andersen,
  • Mariana B. Cartuliares,
  • Eva R. B. Petersen,
  • Thor A. Skovsted,
  • Stefan Posth,
  • Ole Graumann,
  • Morten J. Lorentzen and
  • Helene Skjøt-Arkil
  • + 2 authors

Community-acquired pneumonia is a common cause of acute hospitalisation. Identifying patients with community-acquired pneumonia among patients suspected of having the disease can be a challenge, which causes unnecessary antibiotic treatment. We inves...

(This article belongs to the Special Issue Laboratory Diagnosis of Infectious Diseases)
  • Hypothesis
  • Open Access
6 Citations
5,181 Views
23 Pages

Introducing a Novel Innovative Technique for the Recording and Interpretation of Dynamic Coronary Angiography

  • Thach Nguyen,
  • Khiem Ngo,
  • Tri Loc Vu,
  • Hien Q. Nguyen,
  • Dat H. Pham,
  • Mihas Kodenchery,
  • Marco Zuin,
  • Gianluca Rigatelli,
  • Aravinda Nanjundappa and
  • Michael Gibson

In the study of coronary artery disease (CAD), the mechanism of plaque formation and development is still an important subject for investigation. A limitation of current coronary angiography (CAG) is that it can only show static images of the narrowi...

(This article belongs to the Special Issue Angiography: Diagnostic Imaging in Clinical Diseases)
  • Review
  • Open Access
54 Citations
12,681 Views
25 Pages

Deep Learning for Alzheimer’s Disease Prediction: A Comprehensive Review

  • Isra Malik,
  • Ahmed Iqbal,
  • Yeong Hyeon Gu and
  • Mugahed A. Al-antari

Alzheimer’s disease (AD) is a neurological disorder that significantly impairs cognitive function, leading to memory loss and eventually death. AD progresses through three stages: early stage, mild cognitive impairment (MCI) (middle stage), and...

(This article belongs to the Special Issue Deep Learning in Medical and Biomedical Image Processing)
  • Article
  • Open Access
6 Citations
6,238 Views
11 Pages

Morphological Characteristics of the Double Mental Foramen and Its Relevance in Clinical Practice: An Observational Study

  • Alejandro Bruna-Mejias,
  • Pablo Nova-Baeza,
  • Florencia Torres-Riquelme,
  • Maria Fernanda Delgado-Retamal,
  • Mathias Orellana-Donoso,
  • Alejandra Suazo-Santibañez,
  • Walter Sepulveda-Loyola,
  • Iván Valdés-Orrego,
  • Juan Sanchis-Gimeno and
  • Juan José Valenzuela-Fuenzalida

The mental foramen (MF) is an opening found bilaterally on the anterolateral aspect of the mandible; it can be round or oval and have different diameters. One of the anatomical variants of the jaw is the presence of an accessory mental foramen (AMF)....

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Case Report
  • Open Access
2,041 Views
5 Pages

Whole-Exome Sequencing Revealed a Pathogenic Germline Variant in the Fumarate Hydratase Gene, Leading to the Diagnosis of Hereditary Leiomyomatosis and Renal Cell Cancer

  • Akari Nagashima,
  • Sohshi Morimura,
  • Toshihisa Hamada,
  • Takayuki Shiomi,
  • Ichiro Mori,
  • Naoko Sato,
  • Junko Nomoto,
  • Masaki Tanaka,
  • Shoji Tsuji and
  • Makoto Sugaya

The diagnosis of hereditary skin tumors is difficult for “old” diagnostic tools such as immunohistochemistry. Whole-exome sequencing analysis as a “new” diagnostic tool enables us to make a final diagnosis in spite of unknown...

(This article belongs to the Special Issue Advances in Diagnosis of Skin and Superficial Tissues Disorders—“Old and Emerging” Diagnostic Tools)
  • Article
  • Open Access
20 Citations
5,972 Views
14 Pages

The Impact of AI on Metal Artifacts in CBCT Oral Cavity Imaging

  • Róża Wajer,
  • Adrian Wajer,
  • Natalia Kazimierczak,
  • Justyna Wilamowska and
  • Zbigniew Serafin

Objective: This study aimed to assess the impact of artificial intelligence (AI)-driven noise reduction algorithms on metal artifacts and image quality parameters in cone-beam computed tomography (CBCT) images of the oral cavity. Materials and Method...

(This article belongs to the Special Issue Advances in Oral and Maxillofacial Radiology)
  • Article
  • Open Access
1 Citations
2,292 Views
14 Pages

Non-Invasive Prediction of Choledocholithiasis Using 1D Convolutional Neural Networks and Clinical Data

  • Enrique Mena-Camilo,
  • Sebastián Salazar-Colores,
  • Marco Antonio Aceves-Fernández,
  • Edgard Efrén Lozada-Hernández and
  • Juan Manuel Ramos-Arreguín

This paper introduces a novel one-dimensional convolutional neural network that utilizes clinical data to accurately detect choledocholithiasis, where gallstones obstruct the common bile duct. Swift and precise detection of this condition is critical...

(This article belongs to the Special Issue Pathology of Hepatobiliary Diseases)
  • Article
  • Open Access
2 Citations
2,610 Views
11 Pages

Anxiety and Mood Disruption in Collegiate Athletes Acutely Following Mild Traumatic Brain Injury

  • Rachel Zhang,
  • Michael Martyna,
  • Jordan Cornwell,
  • Masaru Teramoto,
  • Mollie Selfridge,
  • Amanda Brown,
  • Jamshid Ghajar and
  • Angela Lumba-Brown

Objective: To report the symptom burden of anxiety and mood-related indicators following mTBI in collegiate student-athletes. Study Design: Retrospective cohort study of varsity collegiate athletes. Setting: University sports medicine at a tertiary c...

(This article belongs to the Special Issue The Assessment, Diagnosis, and Management of Sport-Related Concussion in Childhood and Adolescence)
  • Article
  • Open Access
5 Citations
5,132 Views
14 Pages

Topographic and Surgical Risk Factors for Early Myopic Regression between Small Incision Lenticule Extraction and Laser In Situ Keratomileusis

  • Chia-Yi Lee,
  • Yu-Ting Jeng,
  • Shun-Fa Yang,
  • Chin-Te Huang,
  • Chen-Cheng Chao,
  • Ie-Bin Lian,
  • Jing-Yang Huang and
  • Chao-Kai Chang

Our objective was to evaluate the topographic and surgical factors of early myopic regression between laser in situ keratomileusis (LASIK) and small-incision lenticule extraction (SMILE). A retrospective case–control study was conducted, and 36...

(This article belongs to the Special Issue New Perspectives in Diagnosis and Management of Eye Diseases)
  • Article
  • Open Access
10 Citations
2,868 Views
11 Pages

Inoculum Size and False-Positive Detection of NDM- and OXA-48-Type Carbapenemases Using Two Multiplex Lateral Flow Assays

  • Chung-Ho Lee,
  • Huiluo Cao,
  • Shuo Jiang,
  • Tammy Ting-Yan Wong,
  • Cindy Wing-Sze Tse and
  • Pak-Leung Ho

The NG-Test CARBA 5 and Carbapenem-resistant K.N.I.V.O. Detection K-Set are lateral flow assays (LFAs) that rapidly detect five carbapenemases (KPC, NDM, IMP, VIM and OXA-48-like). We evaluated the effect of inoculum size on the performance of these...

(This article belongs to the Section Point-of-Care Diagnostics and Devices)
  • Article
  • Open Access
10 Citations
2,765 Views
14 Pages

Early Detection of Inflammation and Malnutrition and Prediction of Acute Events in Hemodialysis Patients through PINI (Prognostic Inflammatory and Nutritional Index)

  • Monica Cordos,
  • Maria-Alexandra Martu,
  • Cristiana-Elena Vlad,
  • Vasilica Toma,
  • Alin Dumitru Ciubotaru,
  • Minerva Codruta Badescu,
  • Ancuta Goriuc and
  • Liliana Foia

Protein-energy wasting and inflammation are major risk factors for complications in hemodialysis patients. As these risk factors are triggered by a pro-inflammatory state, oxidative stress and hemodynamic dysfunction, which overlap in hemodialyzed su...

(This article belongs to the Section Clinical Diagnosis and Prognosis)
  • Review
  • Open Access
3 Citations
4,477 Views
17 Pages

Uterine tumor resembling ovarian sex-cord tumor (UTROSCT) is a rare form of uterine mesenchymal neoplasm. Although UTROSCT generally exhibits benign behavior with a favorable prognosis, this neoplasm is nevertheless classified as being of uncertain m...

(This article belongs to the Special Issue Diagnosis and Management of Uterine Lesions)
  • Case Report
  • Open Access
2 Citations
3,451 Views
7 Pages

A Case of Refractory Vernal Keratoconjunctivitis Showing Improvement after the Administration of Upadacitinib for the Treatment of Atopic Dermatitis

  • Yoshihito Mima,
  • Eri Tsutsumi,
  • Tsutomu Ohtsuka,
  • Ippei Ebato,
  • Yukihiro Nakata,
  • Taro Kubota and
  • Yuta Norimatsu

Vernal keratoconjunctivitis is a persistent allergic ocular disease predominantly mediated by the T-helper 2 lymphocyte-associated immune response. The standard therapeutic approaches for vernal keratoconjunctivitis include topical corticosteroids an...

(This article belongs to the Special Issue Eye Diseases: Diagnosis and Management—2nd Edition)
  • Review
  • Open Access
7 Citations
14,521 Views
16 Pages

Left Ventricular Papillary Muscle: Anatomy, Pathophysiology, and Multimodal Evaluation

  • Shiying Li,
  • Zhen Wang,
  • Wenpei Fu,
  • Fangya Li,
  • Hui Gu,
  • Nan Cui,
  • Yixia Lin,
  • Mingxing Xie and
  • Yali Yang

As an integral part of the mitral valve apparatus, the left ventricle papillary muscle (PM) controls mitral valve closure during systole and participates in the ejection process during left ventricular systole. Mitral regurgitation (MR) is the most i...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
2,508 Views
19 Pages

Community-Based View on Diagnostic Imaging at the End of COVID-19 Pandemic: Online Survey-Assisted Study

  • Nina D. Anfinogenova,
  • Aleksandra S. Maksimova,
  • Tatiana A. Shelkovnikova,
  • Nadezhda I. Ryumshina,
  • Alina D. Kuznetsova,
  • Nazary P. Chesalov,
  • Rostislav S. Karpov,
  • Wladimir Y. Ussov and
  • Alexey N. Repin

(1) Background: An online survey-based observational cross-sectional study aimed at elucidating the experience and attitudes of an unstructured population regarding diagnostic imaging. (2) Methods: Invitations to participate were distributed using mi...

(This article belongs to the Special Issue AI and Big Data in Healthcare)
  • Article
  • Open Access
4 Citations
2,204 Views
24 Pages

Predicting Tumor Dynamics Post-Staged GKRS: Machine Learning Models in Brain Metastases Prognosis

  • Ana-Maria Trofin,
  • Călin Gh. Buzea,
  • Răzvan Buga,
  • Maricel Agop,
  • Lăcrămioara Ochiuz,
  • Dragos Teodor Iancu and
  • Lucian Eva

This study assesses the predictive performance of six machine learning models and a 1D Convolutional Neural Network (CNN) in forecasting tumor dynamics within three months following Gamma Knife radiosurgery (GKRS) in 77 brain metastasis (BM) patients...

(This article belongs to the Special Issue Lesion Detection and Analysis Using Artificial Intelligence—2nd Edition)
  • Article
  • Open Access
1 Citations
2,816 Views
15 Pages

CT Angiography-Guided Needle Insertion for Interstitial Brachytherapy in Locally Advanced Cervical Cancer

  • Alexandra Timea Kirsch-Mangu,
  • Diana Cristina Pop,
  • Alexandru Tipcu,
  • Alexandra Ioana Andries,
  • Gina Iulia Pasca,
  • Zsolt Fekete,
  • Andrei Roman,
  • Alexandru Irimie and
  • Claudia Ordeanu

CT angiography might be a suitable procedure to avoid arterial puncture in combined intracavitary and interstitial brachytherapy for cervical cancer curatively treated with combined chemoradiation and brachytherapy boost. Data in the literature about...

(This article belongs to the Special Issue Imaging for the Diagnosis of Obstetric and Gynecological Diseases)
  • Article
  • Open Access
1 Citations
3,767 Views
13 Pages

Side- and Sinus-Specific Relationships between Chronic Rhinosinusitis and Ischemic Stroke Using Imaging Analyses

  • Eun Hyun Cho,
  • Kyung Hoon Park,
  • Ji Hee Kim,
  • Heejin Kim,
  • Hyo-Jeong Lee and
  • Jee Hye Wee

Recent studies have reported chronic rhinosinusitis (CRS) as an independent risk factor for stroke. However, the association with stroke depending on the affected sinuses has not been explored. This study aimed to elucidate the side- and sinus-specif...

(This article belongs to the Special Issue Advances in Diagnosis and Treatment in Otolaryngology)
  • Editorial
  • Open Access
27 Citations
8,530 Views
6 Pages

Rapid advancements in artificial intelligence (AI) and machine learning (ML) are currently transforming the field of diagnostics, enabling unprecedented accuracy and efficiency in disease detection, classification, and treatment planning. This Specia...

(This article belongs to the Special Issue Artificial Intelligence Advances for Medical Computer-Aided Diagnosis)
  • Article
  • Open Access
6 Citations
2,071 Views
11 Pages

ML Models Built Using Clinical Parameters and Radiomic Features Extracted from 18F-Choline PET/CT for the Prediction of Biochemical Recurrence after Metastasis-Directed Therapy in Patients with Oligometastatic Prostate Cancer

  • Luca Urso,
  • Corrado Cittanti,
  • Luigi Manco,
  • Naima Ortolan,
  • Francesca Borgia,
  • Antonio Malorgio,
  • Giovanni Scribano,
  • Edoardo Mastella,
  • Massimo Guidoboni and
  • Mirco Bartolomei
  • + 2 authors

Oligometastatic patients at [18F]F-Fluorocholine (18F-choline) PET/CT may be treated with metastasis-directed therapy (MDT). The aim of this study was to combine radiomic parameters extracted from 18F-choline PET/CT and clinical data to build machine...

(This article belongs to the Special Issue Artificial Intelligence in Clinical Medical Imaging: 2nd Edition)

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Diagnostics - ISSN 2075-4418