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Diagnostics, Volume 13, Issue 6

March-2 2023 - 204 articles

Cover Story: Liver cancer, including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), is a leading cause of cancer-related deaths worldwide. At present, α-fetoprotein (AFP) is the only widely recognized biomarker for liver cancer, highlighting the urgent need to identify additional biomarkers for this type of cancer. Previous studies have shown that the CmPn signaling network, involving the CCM signaling complex (CSC), progesterone (PRG), classic nuclear PRG receptor (nPR), and non-classic membrane PRG receptor (mPR), is involved in the tumorigenesis of breast and liver cancers. This study investigated the CmPn network and found multiple CmPn members, including CCM1, PAQR7, PGRMC1, and nPRs, may serve as potential biomarkers for the diagnosis and prognosis of liver cancer subtypes, especially in both HCCs and CCAs. View this paper 
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Articles (204)

  • Article
  • Open Access
2,938 Views
10 Pages

Single-Center Experience with Simultaneous Mural Aortic Thrombosis and Peripheral Obstructive Disease in Pre-COVID-19 and COVID-19 Era

  • Filippo Benedetto,
  • Francesco La Corte,
  • Domenico Spinelli,
  • Gabriele Piffaretti,
  • Santi Trimarchi and
  • Giovanni De Caridi

Background: Mural aortic thrombosis associated with chronic peripheral obstruction of the lower limbs is an unusual event. Repeated embolism of instability aortic mural thrombosis caused acute limb ischemia (Rutherford 2 classification) in patients w...

  • Article
  • Open Access
7 Citations
5,266 Views
15 Pages

Development and Validation of a Novel Prognostic Tool to Predict Recurrence of Paroxysmal Atrial Fibrillation after the First-Time Catheter Ablation: A Retrospective Cohort Study

  • Junjie Huang,
  • Hao Chen,
  • Quan Zhang,
  • Rukai Yang,
  • Shuai Peng,
  • Zhijian Wu,
  • Na Liu,
  • Liang Tang,
  • Zhenjiang Liu and
  • Shenghua Zhou

There is no gold standard to tell frustrating outcomes after the catheter ablation of paroxysmal atrial fibrillation (PAF). The study aims to construct a prognostic tool. We retrospectively analyzed 315 patients with PAF who underwent first-time abla...

  • Article
  • Open Access
12 Citations
4,206 Views
15 Pages

Mammaglobin-A Expression Is Highly Specific for Tumors Derived from the Breast, the Female Genital Tract, and the Salivary Gland

  • Natalia Gorbokon,
  • Patrick Timm,
  • David Dum,
  • Anne Menz,
  • Franziska Büscheck,
  • Cosima Völkel,
  • Andrea Hinsch,
  • Maximilian Lennartz,
  • Andreas M Luebke and
  • Claudia Hube-Magg
  • + 14 authors

Human mammaglobin-A (SCGB2A2) is a secretory protein with an unknown function that is used as a diagnostic marker for breast cancer. However, other tumors can also express mammaglobin-A. To comprehensively study patterns of mammaglobin-A expression,...

  • Article
  • Open Access
5 Citations
3,497 Views
21 Pages

Breast cancer (BRCA) has an undesirable prognosis and is the second most common cancer among women after lung cancer. A novel mechanism of programmed cell death called cuproptosis is linked to the development and spread of tumor cells. However, the f...

  • Review
  • Open Access
7 Citations
2,101 Views
12 Pages

The Sarcoma-Specific Instrument to Longitudinally Assess Health-Related Outcomes of the Routine Care Cycle

  • Nasian Mosku,
  • Philip Heesen,
  • Salome Christen,
  • Mario F. Scaglioni,
  • Beata Bode,
  • Gabriela Studer and
  • Bruno Fuchs

Patient-based health related quality of life (HRQoL) measurements are associated with an improvement in quality of care and outcomes. For a complex disease such as sarcoma, there is no disease-specific questionnaire available which covers all clinica...

  • Article
  • Open Access
11 Citations
3,013 Views
22 Pages

MicroRNA-155 and Disease-Related Immunohistochemical Parameters in Cutaneous Melanoma

  • Manal S. Fawzy,
  • Afaf T. Ibrahiem,
  • Naglaa A. Bayomy,
  • Amin K. Makhdoom,
  • Khalid S. Alanazi,
  • Abdulaziz M. Alanazi,
  • Abdulaziz M. Mukhlef and
  • Eman A. Toraih

Cutaneous melanoma is a severe and life-threatening form of skin cancer with growing incidences. While novel interventions have improved prognoses for these patients, early diagnosis of targeted treatment remains the most effective approach. MicroRNA...

  • Article
  • Open Access
4 Citations
4,385 Views
18 Pages

Rare Benign Tumors and Tumor-like Lesions of the Hand without Skin Damage—Clinical, Imagistic and Histopathological Diagnosis, Retrospective Study

  • Mihaela Pertea,
  • Oxana Madalina Grosu,
  • Alexandru Filip,
  • Dan Cristian Moraru,
  • Stefana Luca,
  • Madalina-Cristina Fotea,
  • Sorinel Lunca,
  • Doinita Olinici,
  • Vladimir Poroch and
  • Claudiu Carp
  • + 1 author

Background: The broad spectrum of diagnoses and clinical features of hand tumors and the absence of pathognomonic signs often lead to an inaccurate or delayed diagnosis. However, only a few reports have comprehensively referenced the diagnosis and cl...

  • Article
  • Open Access
4 Citations
2,273 Views
11 Pages

Quantitative Assessment of Lung Volumes and Enhancement in Patients with COVID-19: Role of Dual-Energy CT

  • Giovanni Foti,
  • Chiara Longo,
  • Niccolò Faccioli,
  • Massimo Guerriero,
  • Flavio Stefanini and
  • Dora Buonfrate

Dual-energy computed tomography (DECT) has been used for detecting pulmonary embolism, but the role of lung perfusion DECT as a predictor of prognosis of coronavirus disease 2019 (COVID-19) has not been defined yet. The aim of our study was to explor...

  • Article
  • Open Access
3,509 Views
10 Pages

Ultrasound Placental Remodeling Patterns and Pathology Characteristics in Patients with History of Mild SARS-CoV-2 Infection during Pregnancy

  • Adelina Staicu,
  • Camelia Albu,
  • Georgiana Nemeti,
  • Cosmina Ioana Bondor,
  • Dan Boitor-Borza,
  • Andreia Paraschiva Preda,
  • Andreea Florian,
  • Iulian Gabriel Goidescu,
  • Diana Sachelaru and
  • Nelida Bora
  • + 6 authors

Introduction: This research aims to describe a progressive pattern of ultrasound placental remodeling in patients with a history of SARS-CoV-2 infection during pregnancy. Materials and Methods: This was a longitudinal, cohort study which enrolled 23...

  • Article
  • Open Access
6 Citations
3,103 Views
10 Pages

Relationship between Selected Cephalometric Parameters, Nasolabial Angle and Its Components in Adolescent Females

  • Mikołaj Gołębiowski,
  • Agnieszka Świątkowska,
  • Przemysław Pastuszak and
  • Mansur Rahnama

Nasolabial angle is commonly used to assess the soft tissue profile of the subnasal region. The aim of this retrospective study was to evaluate the relationship between the nasolabial angle, the inclination of the lower border of the nose and upper l...

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Diagnostics - ISSN 2075-4418Creative Common CC BY license