Skip to Content

Diagnostics, Volume 13, Issue 6

2023 March-2 - 204 articles

Cover Story: Liver cancer, including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), is a leading cause of cancer-related deaths worldwide. At present, α-fetoprotein (AFP) is the only widely recognized biomarker for liver cancer, highlighting the urgent need to identify additional biomarkers for this type of cancer. Previous studies have shown that the CmPn signaling network, involving the CCM signaling complex (CSC), progesterone (PRG), classic nuclear PRG receptor (nPR), and non-classic membrane PRG receptor (mPR), is involved in the tumorigenesis of breast and liver cancers. This study investigated the CmPn network and found multiple CmPn members, including CCM1, PAQR7, PGRMC1, and nPRs, may serve as potential biomarkers for the diagnosis and prognosis of liver cancer subtypes, especially in both HCCs and CCAs. View this paper 
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (204)

  • Article
  • Open Access
3,791 Views
10 Pages

Single-Center Experience with Simultaneous Mural Aortic Thrombosis and Peripheral Obstructive Disease in Pre-COVID-19 and COVID-19 Era

  • Filippo Benedetto,
  • Francesco La Corte,
  • Domenico Spinelli,
  • Gabriele Piffaretti,
  • Santi Trimarchi and
  • Giovanni De Caridi

Background: Mural aortic thrombosis associated with chronic peripheral obstruction of the lower limbs is an unusual event. Repeated embolism of instability aortic mural thrombosis caused acute limb ischemia (Rutherford 2 classification) in patients w...

(This article belongs to the Collection Vascular Diseases Diagnostics)
  • Article
  • Open Access
9 Citations
5,959 Views
15 Pages

Development and Validation of a Novel Prognostic Tool to Predict Recurrence of Paroxysmal Atrial Fibrillation after the First-Time Catheter Ablation: A Retrospective Cohort Study

  • Junjie Huang,
  • Hao Chen,
  • Quan Zhang,
  • Rukai Yang,
  • Shuai Peng,
  • Zhijian Wu,
  • Na Liu,
  • Liang Tang,
  • Zhenjiang Liu and
  • Shenghua Zhou

There is no gold standard to tell frustrating outcomes after the catheter ablation of paroxysmal atrial fibrillation (PAF). The study aims to construct a prognostic tool. We retrospectively analyzed 315 patients with PAF who underwent first-time abla...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Article
  • Open Access
19 Citations
5,453 Views
15 Pages

Mammaglobin-A Expression Is Highly Specific for Tumors Derived from the Breast, the Female Genital Tract, and the Salivary Gland

  • Natalia Gorbokon,
  • Patrick Timm,
  • David Dum,
  • Anne Menz,
  • Franziska Büscheck,
  • Cosima Völkel,
  • Andrea Hinsch,
  • Maximilian Lennartz,
  • Andreas M Luebke and
  • Doris Höflmayer
  • + 14 authors

Human mammaglobin-A (SCGB2A2) is a secretory protein with an unknown function that is used as a diagnostic marker for breast cancer. However, other tumors can also express mammaglobin-A. To comprehensively study patterns of mammaglobin-A expression,...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
6 Citations
4,135 Views
21 Pages

Breast cancer (BRCA) has an undesirable prognosis and is the second most common cancer among women after lung cancer. A novel mechanism of programmed cell death called cuproptosis is linked to the development and spread of tumor cells. However, the f...

(This article belongs to the Special Issue Machine Learning in Precise and Personalized Diagnosis)
  • Review
  • Open Access
10 Citations
2,614 Views
12 Pages

The Sarcoma-Specific Instrument to Longitudinally Assess Health-Related Outcomes of the Routine Care Cycle

  • Nasian Mosku,
  • Philip Heesen,
  • Salome Christen,
  • Mario F. Scaglioni,
  • Beata Bode,
  • Gabriela Studer and
  • Bruno Fuchs

Patient-based health related quality of life (HRQoL) measurements are associated with an improvement in quality of care and outcomes. For a complex disease such as sarcoma, there is no disease-specific questionnaire available which covers all clinica...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
13 Citations
3,650 Views
22 Pages

MicroRNA-155 and Disease-Related Immunohistochemical Parameters in Cutaneous Melanoma

  • Manal S. Fawzy,
  • Afaf T. Ibrahiem,
  • Naglaa A. Bayomy,
  • Amin K. Makhdoom,
  • Khalid S. Alanazi,
  • Abdulaziz M. Alanazi,
  • Abdulaziz M. Mukhlef and
  • Eman A. Toraih

Cutaneous melanoma is a severe and life-threatening form of skin cancer with growing incidences. While novel interventions have improved prognoses for these patients, early diagnosis of targeted treatment remains the most effective approach. MicroRNA...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
4 Citations
6,347 Views
18 Pages

Rare Benign Tumors and Tumor-like Lesions of the Hand without Skin Damage—Clinical, Imagistic and Histopathological Diagnosis, Retrospective Study

  • Mihaela Pertea,
  • Oxana Madalina Grosu,
  • Alexandru Filip,
  • Dan Cristian Moraru,
  • Stefana Luca,
  • Madalina-Cristina Fotea,
  • Sorinel Lunca,
  • Doinita Olinici,
  • Vladimir Poroch and
  • Bogdan Veliceasa
  • + 1 author

Background: The broad spectrum of diagnoses and clinical features of hand tumors and the absence of pathognomonic signs often lead to an inaccurate or delayed diagnosis. However, only a few reports have comprehensively referenced the diagnosis and cl...

(This article belongs to the Special Issue Advances in the Diagnosis and Management of Tumors/Cancers)
  • Article
  • Open Access
5 Citations
2,912 Views
11 Pages

Quantitative Assessment of Lung Volumes and Enhancement in Patients with COVID-19: Role of Dual-Energy CT

  • Giovanni Foti,
  • Chiara Longo,
  • Niccolò Faccioli,
  • Massimo Guerriero,
  • Flavio Stefanini and
  • Dora Buonfrate

Dual-energy computed tomography (DECT) has been used for detecting pulmonary embolism, but the role of lung perfusion DECT as a predictor of prognosis of coronavirus disease 2019 (COVID-19) has not been defined yet. The aim of our study was to explor...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
4,563 Views
10 Pages

Ultrasound Placental Remodeling Patterns and Pathology Characteristics in Patients with History of Mild SARS-CoV-2 Infection during Pregnancy

  • Adelina Staicu,
  • Camelia Albu,
  • Georgiana Nemeti,
  • Cosmina Ioana Bondor,
  • Dan Boitor-Borza,
  • Andreia Paraschiva Preda,
  • Andreea Florian,
  • Iulian Gabriel Goidescu,
  • Diana Sachelaru and
  • Daniel Muresan
  • + 6 authors

Introduction: This research aims to describe a progressive pattern of ultrasound placental remodeling in patients with a history of SARS-CoV-2 infection during pregnancy. Materials and Methods: This was a longitudinal, cohort study which enrolled 23...

(This article belongs to the Special Issue Infectious Disease in Pregnancy)
  • Article
  • Open Access
9 Citations
4,490 Views
10 Pages

Relationship between Selected Cephalometric Parameters, Nasolabial Angle and Its Components in Adolescent Females

  • Mikołaj Gołębiowski,
  • Agnieszka Świątkowska,
  • Przemysław Pastuszak and
  • Mansur Rahnama

Nasolabial angle is commonly used to assess the soft tissue profile of the subnasal region. The aim of this retrospective study was to evaluate the relationship between the nasolabial angle, the inclination of the lower border of the nose and upper l...

(This article belongs to the Special Issue New Insights into Diagnosis of Orthodontics)
  • Article
  • Open Access
2,147 Views
13 Pages

Superselective Catheter Angiographies of the Wrist (SCAW): Approaches for Vascularized Bone Grafts

  • Leonie Goelz,
  • Simon Kim,
  • Andreas Eisenschenk,
  • Sven Mutze and
  • Ariane Asmus

Background: This study assesses the variability of the palmar radiocarpal artery (PRCA), dorsal carpal branch of the ulnar artery (DCBUA), and anterior interosseous artery (AIA) in superselective catheter angiographies of the wrist (SCAW). Methods: S...

(This article belongs to the Special Issue Imaging Diagnosis in Musculoskeletal Medicine)
  • Article
  • Open Access
3 Citations
3,645 Views
12 Pages

Involvement of APOBEC3A/B Deletion in Mouse Mammary Tumor Virus (MMTV)-like Positive Human Breast Cancer

  • Nathália de Sousa Pereira,
  • Glauco Akelinghton Freire Vitiello and
  • Marla Karine Amarante

The association between mouse mammary tumor virus (MMTV)-like sequences and human breast cancer (BC) is largely documented in the literature, but further research is needed to determine how they influence carcinogenesis. APOBEC3 cytidine deaminases a...

(This article belongs to the Special Issue Advances in Breast Disease: From Screening to Diagnosis and Therapy)
  • Article
  • Open Access
6 Citations
4,341 Views
12 Pages

Low-Risk Women with Suspicious Microcalcifications in Mammography—Can an Additional Breast MRI Reduce the Biopsy Rate?

  • Patrik Pöschke,
  • Evelyn Wenkel,
  • Carolin C. Hack,
  • Matthias W. Beckmann,
  • Michael Uder and
  • Sabine Ohlmeyer

Background: In the German Mammography Screening Program, 62% of ductal carcinoma in situ (DCIS) and 38% of invasive breast cancers are associated with microcalcifications (MCs). Vacuum-assisted stereotactic breast biopsies are necessary to distinguis...

(This article belongs to the Special Issue Advances in Diagnostic Medical Imaging in 2023)
  • Review
  • Open Access
20 Citations
10,908 Views
14 Pages

Non-Aneurysmal Perimesencephalic Subarachnoid Hemorrhage: A Literature Review

  • Iulian Roman-Filip,
  • Valentin Morosanu,
  • Zoltan Bajko,
  • Corina Roman-Filip and
  • Rodica Ioana Balasa

Spontaneous non-aneurysmal subarachnoid haemorrhage (NAPMSAH) (addressing point 1) is a relatively rare occurrence in clinical settings as it is rarely misdiagnosed and usually involves a significantly better prognosis than the classical aneurysmal p...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
8 Citations
3,610 Views
12 Pages

SARS-CoV-2 Neutralizing Antibodies in Mexican Population: A Five Vaccine Comparison

  • Fernando Alcorta-Nuñez,
  • Diana Cristina Pérez-Ibave,
  • Carlos Horacio Burciaga-Flores,
  • Miguel Ángel Garza,
  • Moisés González-Escamilla,
  • Patricia Rodríguez-Niño,
  • Juan Francisco González-Guerrero,
  • Adelina Alcorta-Garza,
  • Oscar Vidal-Gutiérrez and
  • María Lourdes Garza-Rodríguez
  • + 1 author

Neutralizing antibodies (NAs) are key immunological markers and are part of the humoral response of the adaptive immune system. NA assays determine the presence of functional antibodies to prevent SARS-CoV-2 infection. We performed a real-world evide...

(This article belongs to the Special Issue Molecular Diagnostics of Emerging Pathogens for Infectious Diseases)
  • Review
  • Open Access
72 Citations
12,426 Views
14 Pages

A balanced interaction between the host and its microbiome is crucial to health. Research regarding the significance of the gut and vaginal microbiomes in female health is substantial. However, less data regarding the urinary microbiome are available...

(This article belongs to the Special Issue Microbiome in Urological Diseases)
  • Article
  • Open Access
4 Citations
3,734 Views
12 Pages

Is Laser Therapy an Adjuvant in the Treatment of Peri-Implant Mucositis? A Randomized Clinical Trial

  • Luminița Lazăr,
  • Timea Dakó,
  • Izabella-Éva Mureșan,
  • Mircea Suciu,
  • George-Alexandru Maftei,
  • Monica Tatarciuc and
  • Ana-Petra Lazăr

(1) Background: Early diagnosis and treatment of peri-implant mucositis may reduce inflammatory markers and halt the progression of the condition to peri-implantitis. Adjunctive laser treatment may have therapeutic benefits that are not yet well know...

(This article belongs to the Special Issue Diagnosis and Treatment of Periodontal Diseases in 2022)
  • Communication
  • Open Access
9 Citations
3,870 Views
7 Pages

Invasive pulmonary aspergillosis is associated with high mortality. For diagnosis, galactomannan-antigen in serum and bronchoalveolar lavage fluid is recommended, with higher sensitivity in bronchoalveolar lavage fluid. Because of invasiveness, bronc...

(This article belongs to the Section Diagnostic Microbiology and Infectious Disease)
  • Study Protocol
  • Open Access
7 Citations
2,335 Views
10 Pages

Clinical Value of Novel Echocardiographic Biomarkers Assessing Myocardial Work in Acute Heart Failure—Rationale and Design of the “Beyond Myo-HF Study”

  • Vasileios Anastasiou,
  • Stylianos Daios,
  • Dimitrios V. Moysidis,
  • Maria-Anna Bazmpani,
  • Thomas Zegkos,
  • Theodoros Karamitsos,
  • Kali Makedou,
  • Christos Savopoulos,
  • Georgios Efthimiadis and
  • Vasileios Kamperidis
  • + 1 author

Background. Despite ongoing treatment advancements in chronic heart failure (HF), mortality and readmission rates remain high for patients hospitalized for decompensated acute HF. These patients represent a distinct HF group, which requires emergent...

(This article belongs to the Special Issue Diagnosis of Valvular Heart Disease and Myocardial Function)
  • Article
  • Open Access
8 Citations
4,394 Views
14 Pages

Assessment of Fast-Track Pathway in Hip and Knee Replacement Surgery by Propensity Score Matching on Patient-Reported Outcomes

  • Andrea Campagner,
  • Frida Milella,
  • Stefania Guida,
  • Susan Bernareggi,
  • Giuseppe Banfi and
  • Federico Cabitza

Total hip (THA) and total knee (TKA) arthroplasty procedures have steadily increased over the past few decades, and their use is expected to grow further, mainly due to an increasing number of elderly patients. Cost-containment strategies, supporting...

(This article belongs to the Special Issue Monitoring and Diagnosis of Patients during Rehabilitation Training)
  • Article
  • Open Access
13 Citations
5,587 Views
15 Pages

The Accuracy of Pre-Endoscopic Scores for Mortality Prediction in Patients with Upper GI Bleeding and No Endoscopy Performed

  • Sergiu Marian Cazacu,
  • Dragoș Ovidiu Alexandru,
  • Răzvan-Cristian Statie,
  • Sevastița Iordache,
  • Bogdan Silviu Ungureanu,
  • Vlad Florin Iovănescu,
  • Petrică Popa,
  • Victor Mihai Sacerdoțianu,
  • Carmen Daniela Neagoe and
  • Mirela Marinela Florescu

(1) Background: The assessment of mortality and rebleeding rate in upper gastrointestinal bleeding (UGIB) is essential, and several prognostic scores have been proposed. Some patients with UGIB did not undergo endoscopy, either because they refused t...

(This article belongs to the Section Biomedical Optics)
  • Systematic Review
  • Open Access
16 Citations
4,405 Views
18 Pages

The Prognostic Significance of BRAF Gene Analysis in Children and Adolescents with Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis

  • Eleni P Kotanidou,
  • Styliani Giza,
  • Vasiliki Rengina Tsinopoulou,
  • Kosmas Margaritis,
  • Anastasia Papadopoulou,
  • Eleni Sakellari,
  • Savvas Kolanis,
  • Eleni Litou,
  • Anastasios Serbis and
  • Assimina Galli-Tsinopoulou

Thyroid cancer represents the prominent endocrine cancer in children. Papillary thyroid cancer (PTC) constitutes its most frequent (>90%) pediatric histological type. Mutations energizing the mitogen-activated-protein kinase (MAPK) pathway are def...

(This article belongs to the Special Issue Prognostic Factors for Pediatric Tumors)
  • Article
  • Open Access
4 Citations
2,367 Views
10 Pages

Considering Diastolic Dyssynchrony as a Predictor of Favorable Response in LV-Only Fusion Pacing Cardiac Resynchronization Therapy

  • Andra Gurgu,
  • Constantin-Tudor Luca,
  • Cristina Vacarescu,
  • Lucian Petrescu,
  • Emilia-Violeta Goanta,
  • Mihai-Andrei Lazar,
  • Diana-Aurora Arnăutu and
  • Dragos Cozma

Background: CRT improves systolic and diastolic function, increasing cardiac output. Aim of the study: to assess the outcome of LV diastolic dyssynchrony in a population of fusion pacing CRT. Methods: Diastolic dyssynchrony was measured by offline sp...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Article
  • Open Access
5 Citations
5,720 Views
9 Pages

Adenomyosis in Pregnancy—Should It Be Managed in High-Risk Obstetric Units?

  • Rodrigo Orozco,
  • José Carlos Vilches,
  • Ignacio Brunel,
  • Manuel Lozano,
  • Gema Hernández,
  • David Pérez-Del Rey,
  • Laura Meloni and
  • Juan Luis Alcázar

Background: Uterine adenomyosis is an increasingly frequent disorder. Our study aimed to demonstrate the presence of obstetric complications in the population affected by this condition to demonstrate the need for follow-up in high-risk obstetric uni...

(This article belongs to the Special Issue Advances in Gynecological Ultrasound)
  • Article
  • Open Access
6 Citations
4,835 Views
15 Pages

Concordance between US and MRI Two-Dimensional Measurement and Volumetric Segmentation in Fetal Ventriculomegaly

  • George Hadjidekov,
  • Gleb Haynatzki,
  • Petya Chaveeva,
  • Miroslav Nikolov,
  • Gabriele Masselli and
  • Andrea Rossi

We provide a study comparison between two-dimensional measurement and volumetric (3D) segmentation of the lateral ventricles and brain structures in fetuses with isolated and non-isolated ventriculomegaly with 3D virtual organ computer-aided analysis...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
11 Citations
4,272 Views
10 Pages

First Results of a New Deep Learning Reconstruction Algorithm on Image Quality and Liver Metastasis Conspicuity for Abdominal Low-Dose CT

  • Joël Greffier,
  • Quentin Durand,
  • Chris Serrand,
  • Renaud Sales,
  • Fabien de Oliveira,
  • Jean-Paul Beregi,
  • Djamel Dabli and
  • Julien Frandon

The study’s aim was to assess the impact of a deep learning image reconstruction algorithm (Precise Image; DLR) on image quality and liver metastasis conspicuity compared with an iterative reconstruction algorithm (IR). This retrospective study...

(This article belongs to the Special Issue Quantitative Imaging in Computed Tomography)
  • Article
  • Open Access
3 Citations
3,021 Views
12 Pages

Factors Associated with the Effectiveness of Regimens for the Treatment of Tuberculosis in Patients Coinfected with HIV/AIDS: Cohort 2015 to 2019

  • Natália Helena de Resende,
  • Silvana Spíndola de Miranda,
  • Adriano Max Moreira Reis,
  • Cristiane Aparecida Menezes de Pádua,
  • João Paulo Amaral Haddad,
  • Paulo Vitor Rozario da Silva,
  • Dirce Inês da Silva and
  • Wânia da Silva Carvalho

(1) Background: Infection with the Human Immunodeficiency Virus (HIV) is a significant challenge for tuberculosis (TB) control, with increasing mortality rates worldwide. Moreover, the loss to follow-up is very high, with low adherence to treatment,...

(This article belongs to the Special Issue Detection and Surveillance of Tuberculosis)
  • Article
  • Open Access
12 Citations
4,818 Views
19 Pages

NGAL as Biomarker of Clinical and Subclinical Damage of Kidney Function after Coronary Angiography

  • Iliyana Petrova,
  • Alexander Alexandrov,
  • Georgi Vladimirov,
  • Hristo Mateev,
  • Ivaylo Bogov,
  • Iva Paskaleva and
  • Nina Gotcheva

Contrast-induced acute kidney injury (CI-AKI) is a serious complication after angiographic examinations in cardiology. Diagnosis may be delayed based on standard serum creatinine, and subclinical forms of kidney damage may not be detected at all. In...

(This article belongs to the Special Issue Kidney Disease: Biomarkers, Diagnosis, and Prognosis: 2nd Edition)
  • Article
  • Open Access
20 Citations
9,114 Views
11 Pages

National Knowledge-Driven Management of Obstructive Sleep Apnea—The Swedish Approach

  • Ludger Grote,
  • Carl-Peter Anderberg,
  • Danielle Friberg,
  • Gert Grundström,
  • Kerstin Hinz,
  • Göran Isaksson,
  • Tarmo Murto,
  • Zarita Nilsson,
  • Jonas Spaak and
  • Jan Hedner
  • + 5 authors

Introduction: This paper describes the development of “Swedish Guidelines for OSA treatment” and the underlying managed care process. The Apnea Hypopnea Index (AHI) is traditionally used as a single parameter for obstructive sleep apnea (...

(This article belongs to the Special Issue Diagnosis and Management of Sleep Disorders)
  • Article
  • Open Access
34 Citations
5,045 Views
13 Pages

Automated Identification and Segmentation of Ellipsoid Zone At-Risk Using Deep Learning on SD-OCT for Predicting Progression in Dry AMD

  • Gagan Kalra,
  • Hasan Cetin,
  • Jon Whitney,
  • Sari Yordi,
  • Yavuz Cakir,
  • Conor McConville,
  • Victoria Whitmore,
  • Michelle Bonnay,
  • Jamie L. Reese and
  • Justis P. Ehlers
  • + 1 author

Background: The development and testing of a deep learning (DL)-based approach for detection and measurement of regions of Ellipsoid Zone (EZ) At-Risk to study progression in nonexudative age-related macular degeneration (AMD). Methods: Used in DL mo...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
5 Citations
4,050 Views
13 Pages

The prompt implementation of optimal antibacterial therapy through the rapid identification of the causative organisms is essential for improving outcomes for critically ill patients with bloodstream infections. We evaluated the clinical performance...

(This article belongs to the Special Issue Advances in the Diagnosis of Infectious Diseases and Microorganisms)
  • Article
  • Open Access
65 Citations
6,657 Views
20 Pages

A CAD System for Lung Cancer Detection Using Hybrid Deep Learning Techniques

  • Ahmed A. Alsheikhy,
  • Yahia Said,
  • Tawfeeq Shawly,
  • A. Khuzaim Alzahrani and
  • Husam Lahza

Lung cancer starts and spreads in the tissues of the lungs, more specifically, in the tissue that forms air passages. This cancer is reported as the leading cause of cancer deaths worldwide. In addition to being the most fatal, it is the most common...

(This article belongs to the Special Issue Cardiothoracic Imaging: Diagnostics and Modern Techniques)
  • Article
  • Open Access
8 Citations
8,272 Views
11 Pages

Benefit of 3D Vena Contracta Area over 2D-Based Echocardiographic Methods in Quantification of Functional Mitral Valve Regurgitation

  • Vinzenz M. Jungels,
  • Felix M. Heidrich,
  • Christian Pfluecke,
  • Axel Linke and
  • Krunoslav M. Sveric

Background: The two-dimensional proximal isovelocity surface area (2D PISA) method in the quantification of an effective regurgitation orifice area (EROA) has limitations in functional mitral valve regurgitation (FMR), particularly in non-circular co...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Review
  • Open Access
18 Citations
4,084 Views
11 Pages

Preliminary Findings of the Role of FAPi in Prostate Cancer Theranostics

  • Riccardo Laudicella,
  • Alessandro Spataro,
  • Ludovica Crocè,
  • Giulia Giacoppo,
  • Davide Romano,
  • Valerio Davì,
  • Maria Lopes,
  • Maria Librando,
  • Antonio Nicocia and
  • Sergio Baldari
  • + 8 authors

Prostate cancer (PCa) is the most frequently diagnosed cancer worldwide and the second most common cause of cancer-related deaths among men. Progress in molecular imaging has magnified its clinical management; however, an unmet clinical need involves...

(This article belongs to the Special Issue The Impact of PET/CT Imaging in Oncology)
  • Article
  • Open Access
41 Citations
6,027 Views
14 Pages

Prediction of Perforated and Nonperforated Acute Appendicitis Using Machine Learning-Based Explainable Artificial Intelligence

  • Sami Akbulut,
  • Fatma Hilal Yagin,
  • Ipek Balikci Cicek,
  • Cemalettin Koc,
  • Cemil Colak and
  • Sezai Yilmaz

Background: The primary aim of this study was to create a machine learning (ML) model that can predict perforated and nonperforated acute appendicitis (AAp) with high accuracy and to demonstrate the clinical interpretability of the model with explain...

(This article belongs to the Special Issue Artificial Intelligence Technology in Clinical Classification and Prediction)
  • Article
  • Open Access
13 Citations
6,763 Views
12 Pages

Initial Serum Levels of Magnesium and Calcium as Predictors of Mortality in Traumatic Brain Injury Patients: A Retrospective Study

  • Ahammed Mekkodathil,
  • Ayman El-Menyar,
  • Suhail Hakim,
  • Hisham Al Jogol,
  • Ashok Parchani,
  • Ruben Peralta,
  • Sandro Rizoli and
  • Hassan Al-Thani

Background: We sought to evaluate the predictor role of the initial serum level of calcium and magnesium in hospitalized traumatic brain injury (TBI) patients. Materials and methods: A retrospective analysis of all TBI patients admitted to the Hamad...

(This article belongs to the Special Issue Diagnosis and Management in Trauma Surgery)
  • Article
  • Open Access
9 Citations
7,112 Views
23 Pages

Prediction of Acid-Base and Potassium Imbalances in Intensive Care Patients Using Machine Learning Techniques

  • Ratchakit Phetrittikun,
  • Kerdkiat Suvirat,
  • Kanakorn Horsiritham,
  • Thammasin Ingviya and
  • Sitthichok Chaichulee

Acid–base disorders occur when the body’s normal pH is out of balance. They can be caused by problems with kidney or respiratory function or by an excess of acids or bases that the body cannot properly eliminate. Acid–base and potas...

(This article belongs to the Special Issue Medical Data Processing and Analysis—2nd Edition)
  • Article
  • Open Access
1 Citations
2,592 Views
19 Pages

Three-Dimensional Voxel-Wise Quantitative Assessment of Imaging Features in Hepatocellular Carcinoma

  • Chongfei Huang,
  • Shihong Ying,
  • Meixiang Huang,
  • Chenhui Qiu,
  • Fang Lu,
  • Zhiyi Peng and
  • Dexing Kong

Voxel-wise quantitative assessment of typical characteristics in three-dimensional (3D) multiphase computed tomography (CT) imaging, especially arterial phase hyperenhancement (APHE) and subsequent washout (WO), is crucial for the diagnosis and thera...

(This article belongs to the Special Issue Computed Tomography Imaging in Medical Diagnosis)
  • Article
  • Open Access
21 Citations
4,340 Views
14 Pages

Identifying ITGB2 as a Potential Prognostic Biomarker in Ovarian Cancer

  • Chanyuan Li,
  • Ting Deng,
  • Junya Cao,
  • Yun Zhou,
  • Xiaolin Luo,
  • Yanling Feng,
  • He Huang and
  • Jihong Liu

Epithelial ovarian cancer is by far the most lethal gynecological malignancy. The exploration of promising immunomarkers to predict prognosis in ovarian cancer patients remains challenging. In our research, we carried out an integrated bioinformatic...

(This article belongs to the Special Issue Pathology and Diagnosis of Gynecologic Diseases)
  • Article
  • Open Access
21 Citations
4,142 Views
14 Pages

Background: Fatty liver disease (FLD) is an important risk factor for liver cancer and cardiovascular disease and can lead to significant social and economic burden. However, there is currently no nationwide epidemiological survey for FLD in China, m...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Article
  • Open Access
37 Citations
5,116 Views
27 Pages

Phenotyping the Histopathological Subtypes of Non-Small-Cell Lung Carcinoma: How Beneficial Is Radiomics?

  • Giovanni Pasini,
  • Alessandro Stefano,
  • Giorgio Russo,
  • Albert Comelli,
  • Franco Marinozzi and
  • Fabiano Bini

The aim of this study was to investigate the usefulness of radiomics in the absence of well-defined standard guidelines. Specifically, we extracted radiomics features from multicenter computed tomography (CT) images to differentiate between the four...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Review
  • Open Access
10 Citations
4,198 Views
17 Pages

The Role of Telemedicine in Prehospital Traumatic Hand Injury Evaluation

  • Francisco R. Avila,
  • Rickey E. Carter,
  • Christopher J. McLeod,
  • Charles J. Bruce,
  • Gunel Guliyeva,
  • Ricardo A. Torres-Guzman,
  • Karla C. Maita,
  • Olivia A. Ho,
  • Sarvam P. TerKonda and
  • Antonio J. Forte

Unnecessary ED visits and transfers to hand clinics raise treatment costs and patient burden at trauma centers. In the present COVID-19 pandemic, needless transfers can increase patients’ risk of viral exposure. Therefore, this review analyzes...

(This article belongs to the Section Point-of-Care Diagnostics and Devices)
  • Article
  • Open Access
7 Citations
3,353 Views
13 Pages

SH2 Domain-Containing Phosphatase-SHP2 Attenuates Fibrotic Responses through Negative Regulation of Mitochondrial Metabolism in Lung Fibroblasts

  • Theodoros Karampitsakos,
  • Apostolos Galaris,
  • Ilianna Barbayianni,
  • Giuseppe DeIuliis,
  • Farida Ahangari,
  • Fotis Sampsonas,
  • Vasilina Sotiropoulou,
  • Vassilis Aidinis,
  • Anton M. Bennett and
  • Argyrios Tzouvelekis
  • + 5 authors

Background: We have previously shown that SHP2 downregulation may predispose fibroblasts to differentiate into myofibroblasts and proposed a role for SHP2 downregulation in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Recent data have sho...

(This article belongs to the Section Pathology and Molecular Diagnostics)
  • Systematic Review
  • Open Access
19 Citations
4,022 Views
15 Pages

Radiofrequency Ablation in Vertebral Body Metastasis with and without Percutaneous Cement Augmentation: A Systematic Review Addressing the Need for SPINE Stability Evaluation

  • Stefano Colonna,
  • Andrea Bianconi,
  • Fabio Cofano,
  • Alessandro Prior,
  • Giuseppe Di Perna,
  • Giuseppe Palmieri,
  • Gianluigi Zona,
  • Diego Garbossa and
  • Pietro Fiaschi

Vertebral body metastases (VBM) are one of the most frequent sites of bone metastasis, and their adequate therapeutic management still represents an insidious challenge for both oncologists and surgeons. A possible alternative treatment for VBM is ra...

(This article belongs to the Special Issue Assessment and Management of Instability in Spinal Tumors)
  • Article
  • Open Access
5 Citations
3,787 Views
12 Pages

Coronary Artery Disease in Patients Hospitalized for Peripheral Artery Disease: A Nationwide Analysis of 1.8 Million Patients

  • Magnus Helmer,
  • Christian Scheurig-Muenkler,
  • Verena Brandt,
  • Christian Tesche,
  • Stefanie Bette,
  • Florian Schwarz,
  • Thomas Kroencke and
  • Josua A. Decker

Purpose: Coronary artery disease (CAD) and peripheral artery disease (PAD) are highly prevalent in society. This nationwide analysis aimed to evaluate the trends of in-hospital treatment of patients admitted due to PAD with and without concomitant CA...

(This article belongs to the Section Medical Imaging and Theranostics)
  • Article
  • Open Access
12 Citations
5,542 Views
9 Pages

Comparison of Two Tuberculosis Infection Tests in a South American Tertiary Hospital: STANDARD F TB-Feron FIA vs. QIAreachTM QuantiFERON-TB

  • Gustavo Saint-Pierre,
  • Daniel Conei,
  • Patricia Cantillana,
  • Mariella Raijmakers,
  • Andrea Vera,
  • Daniela Gutiérrez,
  • Cristopher Kennedy,
  • Paulina Peralta and
  • Paulina Ramonda

Introduction: Tuberculosis (TB) is one of the most prevalent respiratory diseases in the world. In 2020 there were at least 9.9 million new infections, with 1.5 million deaths. Approximately 10% of people infected with Mycobacterium tuberculosis deve...

(This article belongs to the Special Issue Detection and Surveillance of Tuberculosis)
  • Article
  • Open Access
4 Citations
3,974 Views
27 Pages

Enhancement of Ultrasound B-Mode Image Quality Using Nonlinear Filtered-Multiply-and-Sum Compounding for Improved Carotid Artery Segmentation

  • Asraf Mohamed Moubark,
  • Luzhen Nie,
  • Mohd Hairi Mohd Zaman,
  • Mohammad Tariqul Islam,
  • Mohd Asyraf Zulkifley,
  • Mohd Hafiz Baharuddin,
  • Zainab Alomari and
  • Steven Freear

In ultrasound B-mode imaging, the axial resolution (AR) is commonly determined by the duration or bandwidth of an excitation signal. A shorter-duration pulse will produce better resolution compared to a longer one but with compromised penetration dep...

(This article belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)
  • Review
  • Open Access
6 Citations
6,613 Views
17 Pages

Anticoagulation for Atrial Fibrillation in Patients with Decompensated Liver Cirrhosis: Bold and Brave?

  • Irina Gîrleanu,
  • Anca Trifan,
  • Laura Huiban,
  • Cristina Maria Muzica,
  • Oana Cristina Petrea,
  • Ana-Maria Sîngeap,
  • Camelia Cojocariu,
  • Stefan Chiriac,
  • Tudor Cuciureanu and
  • Carol Stanciu
  • + 7 authors

Atrial fibrillation is frequently diagnosed in patients with liver cirrhosis, especially in those with non-alcoholic steatohepatitis or alcoholic etiology. Anticoagulant treatment is recommended for thromboembolic protection in patients with atrial f...

(This article belongs to the Special Issue Diagnosis of Liver Disease)
  • Article
  • Open Access
6 Citations
3,008 Views
14 Pages

Correction of Local Brain Temperature after Severe Brain Injury Using Hypothermia and Medical Microwave Radiometry (MWR) as Companion Diagnostics

  • Oleg A. Shevelev,
  • Marina V. Petrova,
  • Elias M. Mengistu,
  • Mikhail Y. Yuriev,
  • Inna Z. Kostenkova,
  • Sergey G. Vesnin,
  • Michael M. Kanarskii,
  • Maria A. Zhdanova and
  • Igor Goryanin

The temperature of the brain can reflect the activity of its different regions, allowing us to evaluate the connections between them. A study involving 111 patients in a vegetative state or minimally conscious state used microwave radiometry to measu...

(This article belongs to the Section Point-of-Care Diagnostics and Devices)

of 5

XFacebookLinkedIn
Diagnostics - ISSN 2075-4418