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Diagnostics, Volume 13, Issue 17

September-1 2023 - 141 articles

Cover Story: Acute Lymphoblastic Leukemia (ALL) is the most common cancer among children and one of the successful cancer therapeutics that is accomplished via the implementation of risk-directed chemotherapy. Nevertheless, leukemia remains a leading cause of cancer-related deaths. The application of next-generation sequencing tools has illustrated the genomic landscape of ALL. However, underlying dynamic changes at the protein level remain a challenge. Proteomics is a cutting-edge technology aimed at deciphering the mechanisms, pathways, and the degree to which the proteome impacts leukemia subtypes. The analysis of high-throughput global proteomic profiles represents an opportunity to unveil new biological markers and druggable targets for innovative and customized therapies providing new prospects for precision-medicine strategies. View this paper
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Articles (141)

  • Review
  • Open Access
8 Citations
5,521 Views
13 Pages

Selective IgM Deficiency: Evidence, Controversies, and Gaps

  • Ivan Taietti,
  • Martina Votto,
  • Maria De Filippo,
  • Matteo Naso,
  • Lorenza Montagna,
  • Daniela Montagna,
  • Amelia Licari,
  • Gian Luigi Marseglia and
  • Riccardo Castagnoli

4 September 2023

Selective Immunoglobulin M deficiency (SIgMD) has been recently included in the inborn errors of immunity (IEI) classification by the International Union of Immunological Societies Expert Committee. The understanding of SIgMD is still extremely limit...

  • Article
  • Open Access
9 Citations
3,037 Views
12 Pages

Identification of Autoantibodies to a Hybrid Insulin Peptide in Type 1 Diabetes

  • Janet M. Wenzlau,
  • Yong Gu,
  • Aaron Michels,
  • Marian Rewers,
  • Kathryn Haskins and
  • Liping Yu

4 September 2023

Type 1 diabetes (T1D) is a chronic autoimmune disease that attacks the insulin-producing b cells of the pancreatic islets. Autoantibodies to b cell proteins typically appear in the circulation years before disease onset, and serve as the most accurat...

  • Article
  • Open Access
5 Citations
2,438 Views
11 Pages

4 September 2023

We evaluated the overall performance of the Cobas 6800 BKV test in detecting BK virus (BKV). We examined the imprecision of the Cobas 6800 BKV test and compared the qualitative and quantitative results obtained from the Cobas 6800 BKV test and the Re...

  • Article
  • Open Access
5 Citations
2,477 Views
20 Pages

A Deep Learning Model Based on Capsule Networks for COVID Diagnostics through X-ray Images

  • Gabriela Rangel,
  • Juan C. Cuevas-Tello,
  • Mariano Rivera and
  • Octavio Renteria

4 September 2023

X-ray diagnostics are widely used to detect various diseases, such as bone fracture, pneumonia, or intracranial hemorrhage. This method is simple and accessible in most hospitals, but requires an expert who is sometimes unavailable. Today, some diagn...

  • Review
  • Open Access
7 Citations
2,438 Views
13 Pages

Hepatic Inflammatory Pseudotumor—Focusing on Its Heterogeneity

  • Soo Ryang Kim,
  • Soo Ki Kim,
  • Yu-ichiro Koma,
  • Motoko Sasaki,
  • Akira Asai and
  • Hiroki Nishikawa

4 September 2023

Hepatic inflammatory pseudotumors (IPTs) are defined as benign, non-malignant, non-metastasizing tumors characterized by the presence of myofibroblastic spindle cells, hetorogenous populations of inflammatory cells, particularly plasma cells, lymphoc...

  • Article
  • Open Access
11 Citations
1,880 Views
10 Pages

Impact of Phacoemulsification Parameters on Central Retinal Thickness Change Following Cataract Surgery

  • Lars H. B. Mackenbrock,
  • Isabella D. Baur,
  • Grzegorz Łabuz,
  • Gerd U. Auffarth and
  • Ramin Khoramnia

4 September 2023

Cataract surgery can lead to inflammatory processes in the retina due to its invasive nature, resulting in prolonged recovery times and reduced functional outcomes. The aim of the current study is to explore the impact that phacoemulsification parame...

  • Article
  • Open Access
1,702 Views
14 Pages

4 September 2023

In this study, we develop an innovative method that assists computer-aided diagnosis in the determination process of the exact location of the femoral neck junction in plain radiographs. Our algorithm consists of two phases, i.e., coarse prediction a...

  • Review
  • Open Access
17 Citations
9,151 Views
17 Pages

4 September 2023

Orofacial pain represents one of the most common health problems that negatively affects the activities of daily living. However, the mechanisms underlying these conditions are still unclear, and their comprehensive management is often lacking. Moreo...

  • Article
  • Open Access
5 Citations
2,222 Views
21 Pages

AI Evaluation of Imaging Factors in the Evolution of Stage-Treated Metastases Using Gamma Knife

  • Calin G. Buzea,
  • Razvan Buga,
  • Maria-Alexandra Paun,
  • Madalina Albu,
  • Dragos T. Iancu,
  • Bogdan Dobrovat,
  • Maricel Agop,
  • Viorel-Puiu Paun and
  • Lucian Eva

4 September 2023

Background: The study investigated whether three deep-learning models, namely, the CNN_model (trained from scratch), the TL_model (transfer learning), and the FT_model (fine-tuning), could predict the early response of brain metastases (BM) to radios...

  • Article
  • Open Access
6 Citations
2,208 Views
19 Pages

Brain–Computer Interface: The HOL–SSA Decomposition and Two-Phase Classification on the HGD EEG Data

  • Mary Judith Antony,
  • Baghavathi Priya Sankaralingam,
  • Shakir Khan,
  • Abrar Almjally,
  • Nouf Abdullah Almujally and
  • Rakesh Kumar Mahendran

3 September 2023

An efficient processing approach is essential for increasing identification accuracy since the electroencephalogram (EEG) signals produced by the Brain–Computer Interface (BCI) apparatus are nonlinear, nonstationary, and time-varying. The inter...

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Diagnostics - ISSN 2075-4418