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Article

Immune Escape Is an Early Event in Pre-Invasive Lesions of Lung Squamous Cell Carcinoma

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Pathology Department, North Hospital, University Hospital of Saint Etienne, Avenue Albert Raimond, CEDEX 2, 42055 Saint Etienne, France
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Thoracic Surgery Department, North Hospital, University Hospital of Saint Etienne, Avenue Albert Raimond, CEDEX 2, 42055 Saint Etienne, France
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Pneumology Department, North Hospital, University Hospital of Saint Etienne, Avenue Albert Raimond, CEDEX 2, 42055 Saint Etienne, France
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Corneal Graft Biology, Engineering and Imaging Laboratory, BiiGC, EA2521, Federative Institute of Research in Sciences and Health Engineering, Faculty of Medicine, Jean Monnet University, 42000 Saint-Etienne, France
*
Author to whom correspondence should be addressed.
Diagnostics 2020, 10(7), 503; https://doi.org/10.3390/diagnostics10070503
Received: 15 June 2020 / Revised: 17 July 2020 / Accepted: 20 July 2020 / Published: 21 July 2020
(This article belongs to the Section Pathology and Molecular Diagnostics)
Bronchial dysplasia is the pre-neoplastic lesion recognized for invasive squamous cell carcinoma. The mechanisms leading to invasive squamous cell carcinoma for this lesion are not fully known. Programmed Death-Ligand 1 (PD-L1) expression by the bronchial dysplasia neoplastic epithelium might suggest a response to immunotherapy. The objective of this work is to further characterize PD-L1 and CD8 expression in bronchial dysplasia and bronchial metaplasia compared to normal bronchial epithelium. Immunohistochemical analysis of PD-L1 and CD8 staining were characterized in bronchial dysplasia of 24 patients and correlated with clinical data. We also compared PD-L1 expression in dysplasia samples to 30 normal epithelium and 20 samples with squamous bronchial metaplasia. PD-L1 was never expressed in normal epithelium and in metaplastic epithelium whereas 37.5% of patients with bronchial dysplasia were stained by PD-L1 (p < 0.001). PD-L1 expression was not related to the degree of dysplasia or a medical history of invasive squamous cell carcinoma, while CD8 expression and its localization were related to medical history of squamous cell carcinoma (p = 0.044). Our results show that PD-L1 is expressed in roughly one third of patients with bronchial dysplasia and is not expressed in normal and metaplastic epithelium. This suggests that PD-L1 is expressed in preneoplastic lesions of squamous cell carcinoma. View Full-Text
Keywords: bronchial dysplasia; PD-L1; CD8; immunotherapy bronchial dysplasia; PD-L1; CD8; immunotherapy
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MDPI and ACS Style

Laville, D.; Casteillo, F.; Yvorel, V.; Tiffet, O.; Vergnon, J.-M.; Péoc’h, M.; Forest, F. Immune Escape Is an Early Event in Pre-Invasive Lesions of Lung Squamous Cell Carcinoma. Diagnostics 2020, 10, 503. https://doi.org/10.3390/diagnostics10070503

AMA Style

Laville D, Casteillo F, Yvorel V, Tiffet O, Vergnon J-M, Péoc’h M, Forest F. Immune Escape Is an Early Event in Pre-Invasive Lesions of Lung Squamous Cell Carcinoma. Diagnostics. 2020; 10(7):503. https://doi.org/10.3390/diagnostics10070503

Chicago/Turabian Style

Laville, David, Francois Casteillo, Violaine Yvorel, Olivier Tiffet, Jean-Michel Vergnon, Michel Péoc’h, and Fabien Forest. 2020. "Immune Escape Is an Early Event in Pre-Invasive Lesions of Lung Squamous Cell Carcinoma" Diagnostics 10, no. 7: 503. https://doi.org/10.3390/diagnostics10070503

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