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Life, Volume 14, Issue 12

December 2024 - 184 articles

Cover Story: This article reviews the mechanisms and potential therapeutic implications of aquaporins (AQPs) in critical illnesses. AQPs are known to facilitate water transport and maintain cellular homeostasis, yet their specific involvement in conditions like sepsis, acute respiratory distress syndrome (ARDS), acute kidney injury (AKI), and acute brain injury (ABI) is less understood. We searched the existing literature and highlighted how the dysregulation of AQPs contributes to fluid imbalances and organ dysfunction in critically ill patients. It seems that altered AQP expression correlates with disease severity and outcomes, suggesting that AQPs could serve as biomarkers and therapeutic targets. This review enhances our understanding of AQPs' multifaceted roles in critical care. View this paper
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Articles (184)

  • Article
  • Open Access
1 Citations
1,815 Views
16 Pages

21 December 2024

Background: Effective management of primary apical periodontitis depends on understanding the dynamic interactions within the root canal microbiome. This study aimed to investigate the effect of sequential antimicrobial phases on the root canal micro...

  • Article
  • Open Access
1,825 Views
15 Pages

Gut Microbiota Regulates the Homeostasis of Dendritic Epidermal T Cells

  • Jinwoo Chung,
  • Joo-Chan Lee,
  • Hanna Oh,
  • Yesung Kim,
  • Suin Lim,
  • Chanu Lee,
  • Yoon-Gyu Shim,
  • Eun-Chong Bang and
  • Jea-Hyun Baek

21 December 2024

Dendritic epidermal T cells (DETCs) are a γδ T cell subset residing in the skin epidermis. Although they have been known for decades, the fate of DETCs has largely remained enigmatic. Recent studies have highlighted the relationship betwe...

  • Article
  • Open Access
1 Citations
2,718 Views
22 Pages

Localization of Secondary Metabolites in Relict Gymnosperms of the Genus Sequoia In Vivo and in Cell Cultures In Vitro, and the Biological Activity of Their Extracts

  • Rima N. Kirakosyan,
  • Elena A. Kalasnikova,
  • Elizaveta A. Bolotina,
  • Abdulrahman Saleh,
  • Anastasiya A. Balakina and
  • Svetlana M. Zaytseva

20 December 2024

In order to scientifically search for new sources of secondary metabolites with valuable qualities for phytopharmacognosy, tasks requiring a step-by-step solution were set. The primary task is the development of technologies for obtaining in vitro hi...

  • Article
  • Open Access
3,865 Views
13 Pages

20 December 2024

Background: Postoperative nausea and vomiting (PONV) remains a frequent and uncomfortable complication in women undergoing robotic gynecological procedures. Despite the use of various preventive strategies, PONV continues to negatively impact recover...

  • Article
  • Open Access
1 Citations
5,795 Views
18 Pages

Metagenome Analysis Identified Novel Microbial Diversity of Sandy Soils Surrounded by Natural Lakes and Artificial Water Points in King Salman Bin Abdulaziz Royal Natural Reserve, Saudi Arabia

  • Yahya S. Al-Awthan,
  • Rashid Mir,
  • Fuad A. Alatawi,
  • Abdulaziz S. Alatawi,
  • Fahad M. Almutairi,
  • Tamer Khafaga,
  • Wael M. Shohdi,
  • Amal M. Fakhry and
  • Basmah M. Alharbi

20 December 2024

Background: Soil microbes play a vital role in the ecosystem as they are able to carry out a number of vital tasks. Additionally, metagenomic studies offer valuable insights into the composition and functional potential of soil microbial communities....

  • Article
  • Open Access
2 Citations
1,780 Views
20 Pages

Genomic Characterization of Probiotic Purple Nonsulfur Bacteria Cereibacter sphaeroides Strains S3W10 and SS15: Implications for Enhanced Shrimp Aquaculture

  • Chollachai Klaysubun,
  • Nattarika Chaichana,
  • Sirikan Suwannasin,
  • Kamonnut Singkhamanan,
  • Thunchanok Yaikhan,
  • Duangporn Kantachote,
  • Rattanaruji Pomwised,
  • Monwadee Wonglapsuwan and
  • Komwit Surachat

20 December 2024

Cereibacter sphaeroides strains S3W10 and SS15, isolated from shrimp ponds, exhibit potential probiotic benefits for aquaculture. In this study, the genomic features of S3W10 and SS15 were thoroughly characterized to evaluate their probiotic properti...

  • Article
  • Open Access
2 Citations
2,295 Views
19 Pages

20 December 2024

Oryza sativa (rice) is a major staple food targeted for increased production to achieve food security. However, increased production is threatened by several biotic and abiotic factors, of which bacterial blight disease caused by Xanthomonas oryzae p...

  • Article
  • Open Access
2 Citations
1,954 Views
17 Pages

Identification of Potential Sepsis Therapeutic Drugs Using a Zebrafish Rapid Screening Approach

  • Mark Widder,
  • Chance Carbaugh,
  • William van der Schalie,
  • Ronald Miller,
  • Linda Brennan,
  • Ashley Moore,
  • Robert Campbell,
  • Kevin Akers,
  • Roseanne Ressner and
  • Monica Martin
  • + 4 authors

20 December 2024

In the military, combat wound infections can progress rapidly to life-threatening sepsis. The discovery of effective small-molecule drugs to prevent and/or treat sepsis is a priority. To identify potential sepsis drug candidates, we used an optimized...

  • Review
  • Open Access
8 Citations
6,413 Views
44 Pages

Exploring Aquaporins in Human Studies: Mechanisms and Therapeutic Potential in Critical Illness

  • Charikleia S. Vrettou,
  • Vasileios Issaris,
  • Stelios Kokkoris,
  • Georgios Poupouzas,
  • Chrysi Keskinidou,
  • Nikolaos S. Lotsios,
  • Anastasia Kotanidou,
  • Stylianos E. Orfanos,
  • Ioanna Dimopoulou and
  • Alice G. Vassiliou

20 December 2024

Aquaporins (AQPs) are membrane proteins facilitating water and other small solutes to be transported across cell membranes. They are crucial in maintaining cellular homeostasis by regulating water permeability in various tissues. Moreover, they regul...

  • Correction
  • Open Access
832 Views
2 Pages

Correction: Tognetti et al. Pattern Analysis of Benign and Malignant Atypical Melanocytic Skin Lesions of Palms and Soles: Variations of Dermoscopic Features According to Anatomic Site and Personal Experience. Life 2024, 14, 659

  • Linda Tognetti,
  • Alessandra Cartocci,
  • Elvira Moscarella,
  • Aimilios Lallas,
  • Emi Dika,
  • Maria Concetta Fargnoli,
  • Caterina Longo,
  • Gianluca Nazzaro,
  • John Paoli and
  • Ignazio Stanganelli
  • + 12 authors

20 December 2024

“Harald Kittler” was not included as an author in the original publication [...]

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Life - ISSN 2075-1729